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- W2326879897 abstract "Micro and nano Au/Cr and Al thin film devices have been fabricated using DC sputtering and e-beam evaporation in combination with e-beam and photo lithography. These devices can be coated with specific reagents to detect and measure the presence of particular antigens and/or complementary DNA sequences with a smaller sample size and at much earlier stages of disease progression compared to current medical diagnostic technologies. Using the device material stack (Au/Cr/Si), we have assessed the binding affinity of Au, Cr, and Si with Protein G, and antibodies for Prostate Specific Antigen (PSA) and Cancer Antigen 125 (CA125), an ovarian cancer-associated antigen. Based on our experiments, we see that the thin gold layer of the Au/Cr/Si samples, provides increased bio-material binding affinity, and the chromium layer has a similar, if not less, binding affinity compared to the silicon chip alone." @default.
- W2326879897 created "2016-06-24" @default.
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- W2326879897 date "2006-01-01" @default.
- W2326879897 modified "2023-09-27" @default.
- W2326879897 title "Micro and Nano Thin Film Devices as Bio-Assays for Cancer Diagnosis" @default.
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- W2326879897 doi "https://doi.org/10.1115/imece2006-15581" @default.
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