Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326901501> ?p ?o ?g. }
- W2326901501 endingPage "18" @default.
- W2326901501 startingPage "12" @default.
- W2326901501 abstract "Posttraumatic osteoarthritis (PTOA) is the most common form of osteoarthritis (OA) of the ankle joint. PTOA occurs as a result of several factors, including the poor regenerative capacity of hyaline articular cartilage as well as increased contact stresses following trauma. The purpose of this article is to review the epidemiology, pathogenesis, and potential targets for treatment of PTOA in the ankle joint. Previous reviews primarily addressed clinical approaches to ankle PTOA, while the focus of the current article will be specifically on the newly acquired knowledge of the cellular mechanisms that drive PTOA in the ankle joint and means for potential targeted therapeutics that might halt the progression of cartilage degeneration and/or improve the outcome of surgical interventions. Three experimental treatment strategies are discussed in this review: (1) increasing the anabolic potential of chondrocytes through treatment with growth factors such as bone morphogenetic protein-7; (2) limiting chondrocyte cell death either through the protection of cell membrane with poloxamer 188 or inhibiting activity of intracellular proteases, caspases, which are responsible for cell death by apoptosis; and (3) inhibiting catabolic/inflammatory responses of chondrocytes by treating them with anti-inflammatory agents such as tumor necrosis factor-α antagonists. Future studies should focus on identifying the appropriate timing for treatment and an appropriate combination of anti-inflammatory, chondro- and matrix-protective biologics to limit the progression of trauma-induced cartilage degeneration and prevent the development of PTOA in the ankle joint." @default.
- W2326901501 created "2016-06-24" @default.
- W2326901501 creator A5028829758 @default.
- W2326901501 creator A5033529496 @default.
- W2326901501 creator A5034687744 @default.
- W2326901501 creator A5061036175 @default.
- W2326901501 creator A5075404864 @default.
- W2326901501 date "2016-06-23" @default.
- W2326901501 modified "2023-10-16" @default.
- W2326901501 title "Peculiarities in Ankle Cartilage" @default.
- W2326901501 cites W1773521324 @default.
- W2326901501 cites W1892679171 @default.
- W2326901501 cites W191631078 @default.
- W2326901501 cites W1949422377 @default.
- W2326901501 cites W1966491943 @default.
- W2326901501 cites W1971760055 @default.
- W2326901501 cites W1972313268 @default.
- W2326901501 cites W1980722748 @default.
- W2326901501 cites W1986785213 @default.
- W2326901501 cites W1992193707 @default.
- W2326901501 cites W1997408879 @default.
- W2326901501 cites W1999023153 @default.
- W2326901501 cites W2011038175 @default.
- W2326901501 cites W2011092653 @default.
- W2326901501 cites W2021831266 @default.
- W2326901501 cites W2023140839 @default.
- W2326901501 cites W2024452130 @default.
- W2326901501 cites W2029861410 @default.
- W2326901501 cites W2039617707 @default.
- W2326901501 cites W2056835439 @default.
- W2326901501 cites W2057729474 @default.
- W2326901501 cites W2058932182 @default.
- W2326901501 cites W2067011778 @default.
- W2326901501 cites W2070974940 @default.
- W2326901501 cites W2077296671 @default.
- W2326901501 cites W2091921078 @default.
- W2326901501 cites W2111579522 @default.
- W2326901501 cites W2114954785 @default.
- W2326901501 cites W2133915381 @default.
- W2326901501 cites W2150673069 @default.
- W2326901501 cites W2151451049 @default.
- W2326901501 cites W2157941966 @default.
- W2326901501 cites W2160727749 @default.
- W2326901501 cites W2166265470 @default.
- W2326901501 cites W2167037356 @default.
- W2326901501 cites W2168144236 @default.
- W2326901501 cites W2256835044 @default.
- W2326901501 cites W2281256922 @default.
- W2326901501 cites W2324755165 @default.
- W2326901501 cites W2408885326 @default.
- W2326901501 cites W2415806539 @default.
- W2326901501 cites W2466145824 @default.
- W2326901501 cites W570101915 @default.
- W2326901501 doi "https://doi.org/10.1177/1947603516642572" @default.
- W2326901501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5154419" @default.
- W2326901501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27994716" @default.
- W2326901501 hasPublicationYear "2016" @default.
- W2326901501 type Work @default.
- W2326901501 sameAs 2326901501 @default.
- W2326901501 citedByCount "21" @default.
- W2326901501 countsByYear W23269015012017 @default.
- W2326901501 countsByYear W23269015012019 @default.
- W2326901501 countsByYear W23269015012020 @default.
- W2326901501 countsByYear W23269015012021 @default.
- W2326901501 countsByYear W23269015012022 @default.
- W2326901501 countsByYear W23269015012023 @default.
- W2326901501 crossrefType "journal-article" @default.
- W2326901501 hasAuthorship W2326901501A5028829758 @default.
- W2326901501 hasAuthorship W2326901501A5033529496 @default.
- W2326901501 hasAuthorship W2326901501A5034687744 @default.
- W2326901501 hasAuthorship W2326901501A5061036175 @default.
- W2326901501 hasAuthorship W2326901501A5075404864 @default.
- W2326901501 hasBestOaLocation W23269015011 @default.
- W2326901501 hasConcept C105702510 @default.
- W2326901501 hasConcept C142724271 @default.
- W2326901501 hasConcept C190283241 @default.
- W2326901501 hasConcept C204787440 @default.
- W2326901501 hasConcept C2776164576 @default.
- W2326901501 hasConcept C2778640784 @default.
- W2326901501 hasConcept C2779354088 @default.
- W2326901501 hasConcept C2780550940 @default.
- W2326901501 hasConcept C2781403057 @default.
- W2326901501 hasConcept C31573885 @default.
- W2326901501 hasConcept C35496256 @default.
- W2326901501 hasConcept C55493867 @default.
- W2326901501 hasConcept C60644358 @default.
- W2326901501 hasConcept C71924100 @default.
- W2326901501 hasConcept C86803240 @default.
- W2326901501 hasConceptScore W2326901501C105702510 @default.
- W2326901501 hasConceptScore W2326901501C142724271 @default.
- W2326901501 hasConceptScore W2326901501C190283241 @default.
- W2326901501 hasConceptScore W2326901501C204787440 @default.
- W2326901501 hasConceptScore W2326901501C2776164576 @default.
- W2326901501 hasConceptScore W2326901501C2778640784 @default.
- W2326901501 hasConceptScore W2326901501C2779354088 @default.
- W2326901501 hasConceptScore W2326901501C2780550940 @default.
- W2326901501 hasConceptScore W2326901501C2781403057 @default.
- W2326901501 hasConceptScore W2326901501C31573885 @default.