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• W2326930007 abstract "Although the genetic etiology of familial Mediterranean fever (FMF) is known, limited information is available regarding the regulation of inflammation during attack-free periods. The aim of this study was to determine the alterations in serum copper (Cu), zinc (Zn) and selenium (Se) levels that may be associated with inflammation during attack-free periods in FMF patients.This study included 33 patients with FMF and 30 healthy volunteers. Erythrocyte sedimentation rate (ESR), the serum C-reactive protein (CRP) level and serum levels of Cu, Zn and Se in FMF patients and healthy volunteers were assessed by the atomic absorption spectrophotometry method.ESR and serum CRP levels and serum Cu and Zn levels were similar between patients with FMF during an attack-free period and healthy controls (p>0.05). Serum Se levels in the patient group were significantly higher than in the control group (p<0.05).Our study shows that levels of trace elements in serum are variable in patients with FMF during attack-free periods. Serum Se concentrations may at least in part contribute to the subclinical inflammation in FMF patients during attack-free periods. However, further studies are necessary to confirm this result.Ailesel Akdeniz ateşi (FMF) hastalığının genetik etiyolojisi bilinmesine rağmen, ataksız dönemdeki inflamasyonun düzenlenişi hakkındaki bilgiler sınırlıdır. Bu çalışmanın amacı, FMF hastalığının ataksız döneminde inflamasyonla ilişkili olabilecek serum bakır (Cu), çinko (Zn) ve selenyum (Se) seviyelerindeki değişimleri değerlendirmektir.Bu çalışma 33 FMF hastası ve 30 sağlıklı gönüllüyle düzenlendi. FMF hastalarındaki eritrosit sedimentasyon hızı (ESH), serum C reaktif protein (CRP), Cu, Zn ve Se düzeyleri atomik absorbsiyon spektrofotometri metoduyla değerlendirildi.ESH, serum CRP, Cu ve Zn seviyeleri ataksız periyottaki FMF hastaları ve sağlıklı kontroller arasında benzer düzeydeydi (p>0.05). Hasta grubunda serum Se düzeyleri kontrol grubundan anlamlı derecede daha yüksekti (p<0.05).Bizim çalışmamız ataksız dönemdeki FMF hastalarında serumdaki eser element seviyelerinin değişken olabildiğini göstermektedir. Serum Se konsantrasyonları FMF hastalarında en azından ataksız dönemdeki subklinik inflamasyona katkıda bulunabilir. Bu sonuçları değerlendirmek için yeni çalışmalara ihtiyaç bulunmaktadır." @default.
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• W2326930007 date "2011-08-01" @default.
• W2326930007 modified "2023-10-16" @default.
• W2326930007 title "Trace Element Levels in Patients with Familial Mediterranean Fever" @default.
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• W2326930007 doi "https://doi.org/10.5152/eajm.2011.18" @default.
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