FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326952010> ?p ?o ?g. }

• W2326952010 endingPage "2377" @default.
• W2326952010 startingPage "2377" @default.
• W2326952010 abstract "Abstract Background: As non-small cell lung cancer (NSCLC) is a leading cause of cancer deaths, new prognostic and predictive markers are highly warranted. Monocarboxylate transporters (MCTs) 1 and 4 are transmembrane transporters of lactate and puruvate and are central in cancer cell metabolism. The biological and prognostic importance of MCT1 and MCT4 is not thoroughly studied in NSCLC. Herein, we aimed to explore the prognostic impact on disease specific survival (DSS) in both tumor and stromal cells from NSCLC-patients. Methods: Tissue micro arrays (TMAs) were constructed, representing both epithelial tumor tissue and stromal tissue from 335 unselected patients diagnosed with NSCLC I-IIIA. Immunohistochemistry was used to evaluate the expression of MCT1 and MCT4. Results: MCT1 and MCT4 expression was located to the cell membrane. In univariate analyses, patients with high MCT1 expression in tumors had a favorable disease-specific survival (DSS) (p=0.021). While high expression of MCT1 in stroma was associated with poor DSS (p=0.003). High expression of MCT4 in tumor was a negative prognostic factor (p=0.027), while high expression of MCT4 in stroma showed a trend toward being a positive prognostic factor (p=0.11). In the multivariate analysis, MCT1 in tumor was independently and significantly associated with a favorable DSS (HR = 1.80, CI 95% 1.23-2.64, p=0.003). MCT1 in stroma was independently and significantly associated with a poor DSS (HR = 1.7, CI 95% 1.1-2.7, p=0.016). MCT4 in tumor had no significant prognostic impact in the multivariate analysis. Conclusions: High expression of MCT1 in tumor and stroma is an independent prognostic marker for NSCLC survival, and is therefore a candidate marker for prognostic stratification in NSCLC. These results also highlight the differential, but possible cooperative energy metabolism in tumor and stroma for NSCLC-patients. Citation Format: Marte Eilertsen, Sigve Andersen, Samer Al-Saad, Yury Kiselev, Tom Donnem, Helge Stenvold, Khalid Al-Shibli, Elin Richardsen, Lill-Tove Busund, Roy Martin Bremnes. MCT1 and MCT4 in NSCLC: Overexpression of MCT1 in tumor and stroma is an independent prognostic marker for NSCLC survival. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2377. doi:10.1158/1538-7445.AM2013-2377" @default.
• W2326952010 created "2016-06-24" @default.
• W2326952010 creator A5015431535 @default.
• W2326952010 creator A5021379707 @default.
• W2326952010 creator A5022967795 @default.
• W2326952010 creator A5029902139 @default.
• W2326952010 creator A5037184451 @default.
• W2326952010 creator A5044573605 @default.
• W2326952010 creator A5070642238 @default.
• W2326952010 creator A5081738251 @default.
• W2326952010 creator A5084207494 @default.
• W2326952010 creator A5086917791 @default.
• W2326952010 date "2013-04-01" @default.
• W2326952010 modified "2023-10-14" @default.
• W2326952010 title "Abstract 2377: MCT1 and MCT4 in NSCLC: Overexpression of MCT1 in tumor and stroma is an independent prognostic marker for NSCLC survival." @default.
• W2326952010 doi "https://doi.org/10.1158/1538-7445.am2013-2377" @default.
• W2326952010 hasPublicationYear "2013" @default.
• W2326952010 type Work @default.
• W2326952010 sameAs 2326952010 @default.
• W2326952010 citedByCount "1" @default.
• W2326952010 countsByYear W23269520102019 @default.
• W2326952010 crossrefType "journal-article" @default.
• W2326952010 hasAuthorship W2326952010A5015431535 @default.
• W2326952010 hasAuthorship W2326952010A5021379707 @default.
• W2326952010 hasAuthorship W2326952010A5022967795 @default.
• W2326952010 hasAuthorship W2326952010A5029902139 @default.
• W2326952010 hasAuthorship W2326952010A5037184451 @default.
• W2326952010 hasAuthorship W2326952010A5044573605 @default.
• W2326952010 hasAuthorship W2326952010A5070642238 @default.
• W2326952010 hasAuthorship W2326952010A5081738251 @default.
• W2326952010 hasAuthorship W2326952010A5084207494 @default.
• W2326952010 hasAuthorship W2326952010A5086917791 @default.
• W2326952010 hasConcept C121608353 @default.
• W2326952010 hasConcept C126322002 @default.
• W2326952010 hasConcept C142724271 @default.
• W2326952010 hasConcept C143998085 @default.
• W2326952010 hasConcept C144301174 @default.
• W2326952010 hasConcept C16930146 @default.
• W2326952010 hasConcept C193270364 @default.
• W2326952010 hasConcept C204232928 @default.
• W2326952010 hasConcept C38180746 @default.
• W2326952010 hasConcept C502942594 @default.
• W2326952010 hasConcept C52124034 @default.
• W2326952010 hasConcept C71924100 @default.
• W2326952010 hasConceptScore W2326952010C121608353 @default.
• W2326952010 hasConceptScore W2326952010C126322002 @default.
• W2326952010 hasConceptScore W2326952010C142724271 @default.
• W2326952010 hasConceptScore W2326952010C143998085 @default.
• W2326952010 hasConceptScore W2326952010C144301174 @default.
• W2326952010 hasConceptScore W2326952010C16930146 @default.
• W2326952010 hasConceptScore W2326952010C193270364 @default.
• W2326952010 hasConceptScore W2326952010C204232928 @default.
• W2326952010 hasConceptScore W2326952010C38180746 @default.
• W2326952010 hasConceptScore W2326952010C502942594 @default.
• W2326952010 hasConceptScore W2326952010C52124034 @default.
• W2326952010 hasConceptScore W2326952010C71924100 @default.
• W2326952010 hasIssue "8_Supplement" @default.
• W2326952010 hasLocation W23269520101 @default.
• W2326952010 hasOpenAccess W2326952010 @default.
• W2326952010 hasPrimaryLocation W23269520101 @default.
• W2326952010 hasRelatedWork W1987590349 @default.
• W2326952010 hasRelatedWork W2002418205 @default.
• W2326952010 hasRelatedWork W2097534329 @default.
• W2326952010 hasRelatedWork W2134995196 @default.
• W2326952010 hasRelatedWork W2147489772 @default.
• W2326952010 hasRelatedWork W2365998577 @default.
• W2326952010 hasRelatedWork W2400236695 @default.
• W2326952010 hasRelatedWork W2412122492 @default.
• W2326952010 hasRelatedWork W3048369603 @default.
• W2326952010 hasRelatedWork W4303628870 @default.
• W2326952010 hasVolume "73" @default.
• W2326952010 isParatext "false" @default.
• W2326952010 isRetracted "false" @default.
• W2326952010 magId "2326952010" @default.
• W2326952010 workType "article" @default.