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• W2327032473 abstract "You have accessJournal of UrologyBladder Cancer: Invasive (I)1 Apr 20131429 OVEREXPRESSION OF IGF1R PREDICTS OUTCOME IN INVASIVE UROTHELIAL CARCINOMA OF URINARY BLADDER Nilda Gonzalez-Roibon, Jenny KIM, Alcides Chaux, Enrico Munari, Sheila Faraj, Carla Ellis, Rajni Sharma, Trinity Bivalacqua, Mark Schoenberg, Michael Carducci, and George Netto Nilda Gonzalez-RoibonNilda Gonzalez-Roibon Baltimore, MD More articles by this author , Jenny KIMJenny KIM Baltimore, MD More articles by this author , Alcides ChauxAlcides Chaux Asuncion, Paraguay More articles by this author , Enrico MunariEnrico Munari Baltimore, MD More articles by this author , Sheila FarajSheila Faraj Baltimore, MD More articles by this author , Carla EllisCarla Ellis Baltimore, MD More articles by this author , Rajni SharmaRajni Sharma Baltimore, MD More articles by this author , Trinity BivalacquaTrinity Bivalacqua Baltimore, MD More articles by this author , Mark SchoenbergMark Schoenberg Baltimore, MD More articles by this author , Michael CarducciMichael Carducci Baltimore, MD More articles by this author , and George NettoGeorge Netto Baltimore, MD More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2783AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase receptor involved in cell proliferation and differentiation. IGF1R is overexpressed in several tumors including bladder cancer and is currently under investigation as a target of therapy. We explored IGF1R expression in urothelial carcinoma (UC) and its association with clinicopathologic parameters and prognostic role. METHODS Five tissue microarrays (TMA) were constructed from 100 cystectomy specimens performed for invasive UC at our institution (1994 to 2007). Formalin-fixed paraffin-embedded paired tumor and benign samples were spotted 3-4 times each. Membranous IGF1R staining was evaluated using immunohistochemistry (G11, Ventana Medical Systems). A scoring method analogous to that of Her2 expression in breast cancer was used and the highest score was assigned to each tumor. IGF1R was considered overexpressed in cases with score 1. Endpoints of the study included overall survival (OS) and cancer-specific survival (DSS). Patients were followed-up for a median of 33.5 months (range: 1-141 months). RESULTS We found IGF1R overexpression in 62% of UC. No differences were noted between normal urothelium and UC regarding IGF1R overexpression (74% vs. 60%; P=0.14). IGF1R overexpression was more frequent in tumors from African-American patients compared to Caucasians (100% vs. 59%, P=0.04). Tumors at stage pT4 overexpressed IGF1R less frequently than tumors at stages pT1-pT3 (29% vs. 71%, P=0.005). We did not find any association with other analyzed clinicopathologic parameters such as patient's age or gender, muscularis propria invasion, or lymph node metastasis. OS and DSS rates were 58% and 69%, respectively. Patients with tumors overexpressing IGF1R had a lower OS and DSS compared to those without IGF1R overexpression (Mantel-Cox P=0.0007 and P=0.006, respectively). Using Cox proportional hazards regression, IGF1R overexpression remained a significant predictor of OS (HR=3.49, P=0.001) and DSS (HR=3.54, P=0.007) after adjusting for pathologic stage. CONCLUSIONS Overexpression of IGF1R was found in 62% of UC. High stage tumors overexpressed IGF1R more frequently than low stage tumors. More importantly, IGF1R overexpression was a significant independent predictor of OS and DSS, suggesting its usefulness as a prognosticator in UC. The findings also point to IGF1R as a potential target of therapy in UC. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e585 Peer Review Report Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Nilda Gonzalez-Roibon Baltimore, MD More articles by this author Jenny KIM Baltimore, MD More articles by this author Alcides Chaux Asuncion, Paraguay More articles by this author Enrico Munari Baltimore, MD More articles by this author Sheila Faraj Baltimore, MD More articles by this author Carla Ellis Baltimore, MD More articles by this author Rajni Sharma Baltimore, MD More articles by this author Trinity Bivalacqua Baltimore, MD More articles by this author Mark Schoenberg Baltimore, MD More articles by this author Michael Carducci Baltimore, MD More articles by this author George Netto Baltimore, MD More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2327032473 title "1429 OVEREXPRESSION OF IGF1R PREDICTS OUTCOME IN INVASIVE UROTHELIAL CARCINOMA OF URINARY BLADDER" @default.
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