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- W2327059969 abstract "Two Negro patients with hypertension failed to achieve sodium balance after six to nine days on a diet containing 10 mEq of sodium and 100 mEq of potassium. Whereas plasma renin activity and plasma angiotensin II showed a normal response to sodium depletion, the aldosterone secretion rate (ASR) was inappropriately low. After ACTH stimulation, a normal increase in both the ASR and glucocorticoid excretion was observed. Each patient was able to conserve sodium when given desoxycorticosterone acetate or when endogenous aldosterone was stimulated by ACTH. The data suggest that in these patients, hypoaldosteronism is secondary to defective stimulation of aldosterone by angiotensin II. It is proposed that the elevated blood pressure is causally related to this defect." @default.
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- W2327059969 date "1969-07-17" @default.
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- W2327059969 title "Hypertension with Inappropriate Aldosterone Stimulation" @default.
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- W2327059969 doi "https://doi.org/10.1056/nejm196907172810304" @default.
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