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- W2327124511 abstract "The participation of coagulation/fibrinolysis system in the pathogenesis of renal disease, particularly glomerulonephritis has drawn much attention among specialists of nephrology as well as of blood coagulation and fibrinolysis. And some evidences have been obtained sofar such as1) Morphologic and immunopathologic studies demonstrating fibrin and F. VIII deposition2) Histochemical changes in renal cortical plasminogen activator activity3) Extraction and isolation of plasminogen activator from renal medullary layer4) Changes in coagulation parameters (fibrinogen, F. VIII, prothrombin, plasminogen and inhibitors)5) Injuries by DIC on kidney (microangiopathic hemolytic anemia, thrombotic thrombocytopenic purpura6) Changes in platelet functions and kinin-kallikrein system7) Elevation in fibrinogen-fibrin related antigens and FDP in serum and urine8) Deposition of platelet and FDP in kidney9) Radioisotopic kinetic studies on fibrinogen, plasminogen and platelet (survival)10) Analogy to experimental modelsHowever, there are remained still many questions and discrepancies for establishing apparent and concrete causal relationship between these reaction systems and development of glomerulonephritis; for instance, on1) Existence of so many patients in whom pathoclinical signs and changes of coagulation and fibrinolysis do not accord.2) Possibility for coagulation and fibrinolysis system to be secondary subsequent results to immunologic reactions in glomerulonephritis.3) Evaluation of the effects obtained by the administration of anticoagulants and platelet suppressive agents to patients, and their reaction mechanisms inside of body.4) Explanation for changes in coagulation and fibrinolysis system in patients of renal diseases which are induced by infection, intoxication, malignant tumor and pure hemorheological disorders other than immunological reaction." @default.
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- W2327124511 date "1979-01-01" @default.
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- W2327124511 title "Does coagulation/fibrinolysis system participate in the pathogenesis of glomerulonephritis?" @default.
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- W2327124511 doi "https://doi.org/10.2491/jjsth1970.10.165" @default.
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