Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327132091> ?p ?o ?g. }
- W2327132091 endingPage "129" @default.
- W2327132091 startingPage "119" @default.
- W2327132091 abstract "Insulin-like growth factor I (IGF-I) is a strong anabolic peptide with promising therapeutic value in muscle wasting diseases such as sarcopenia. We report a pulmonary IGF-I delivery system deploying silk-fibroin (SF) as carrier and in comparison to trehalose. Both IGF-I delivery systems were characterized regarding IGF-I integrity, IGF-I release profiles and aerodynamic properties. Transepithelial in vitro transport of IGF-I using the pulmonary Calu-3 model cell system followed comparable kinetics and mechanism of uptake as earlier demonstrated for insulin (INS), for which effective pulmonary delivery is known. Microparticles were spray-dried using either trehalose or SF, resulting in geometries allowing alveolar deposition. The effective IGF-I shuttling through the epithelial barrier of the lung was demonstrated in an ex vivo human lung lobe model, and expanded the exciting possibility of this administration route to this effective and anabolic peptide." @default.
- W2327132091 created "2016-06-24" @default.
- W2327132091 creator A5000977163 @default.
- W2327132091 creator A5001051737 @default.
- W2327132091 creator A5001228240 @default.
- W2327132091 creator A5011902296 @default.
- W2327132091 creator A5021152645 @default.
- W2327132091 creator A5039768593 @default.
- W2327132091 creator A5040653638 @default.
- W2327132091 creator A5045501619 @default.
- W2327132091 creator A5056893187 @default.
- W2327132091 creator A5067478835 @default.
- W2327132091 creator A5074903461 @default.
- W2327132091 date "2015-01-29" @default.
- W2327132091 modified "2023-10-14" @default.
- W2327132091 title "Pulmonary Insulin-like Growth Factor I Delivery from Trehalose and Silk-Fibroin Microparticles" @default.
- W2327132091 cites W1502026371 @default.
- W2327132091 cites W1530473805 @default.
- W2327132091 cites W1942635736 @default.
- W2327132091 cites W1965658712 @default.
- W2327132091 cites W1966678025 @default.
- W2327132091 cites W1970410950 @default.
- W2327132091 cites W1971050119 @default.
- W2327132091 cites W1973043293 @default.
- W2327132091 cites W1974226220 @default.
- W2327132091 cites W1979266796 @default.
- W2327132091 cites W1984064837 @default.
- W2327132091 cites W1984675243 @default.
- W2327132091 cites W1986863857 @default.
- W2327132091 cites W1991498502 @default.
- W2327132091 cites W1996224452 @default.
- W2327132091 cites W1997552453 @default.
- W2327132091 cites W2003847663 @default.
- W2327132091 cites W2005073389 @default.
- W2327132091 cites W2005179225 @default.
- W2327132091 cites W2005779824 @default.
- W2327132091 cites W2006817353 @default.
- W2327132091 cites W2007039329 @default.
- W2327132091 cites W2007901852 @default.
- W2327132091 cites W2011024089 @default.
- W2327132091 cites W2016565975 @default.
- W2327132091 cites W2017686654 @default.
- W2327132091 cites W2019930147 @default.
- W2327132091 cites W2020430388 @default.
- W2327132091 cites W2022533284 @default.
- W2327132091 cites W2026230444 @default.
- W2327132091 cites W2028018581 @default.
- W2327132091 cites W2028867794 @default.
- W2327132091 cites W2034461065 @default.
- W2327132091 cites W2039698899 @default.
- W2327132091 cites W2042549439 @default.
- W2327132091 cites W2045830393 @default.
- W2327132091 cites W2050700255 @default.
- W2327132091 cites W2054988877 @default.
- W2327132091 cites W2061362977 @default.
- W2327132091 cites W2067194409 @default.
- W2327132091 cites W2067878703 @default.
- W2327132091 cites W2069544963 @default.
- W2327132091 cites W2076676105 @default.
- W2327132091 cites W2082562584 @default.
- W2327132091 cites W2083664629 @default.
- W2327132091 cites W2086268872 @default.
- W2327132091 cites W2087572427 @default.
- W2327132091 cites W2094732171 @default.
- W2327132091 cites W2095306595 @default.
- W2327132091 cites W2100837269 @default.
- W2327132091 cites W2104162870 @default.
- W2327132091 cites W2109398776 @default.
- W2327132091 cites W2112032807 @default.
- W2327132091 cites W2115384001 @default.
- W2327132091 cites W2119586900 @default.
- W2327132091 cites W2123545912 @default.
- W2327132091 cites W2125225672 @default.
- W2327132091 cites W2132915404 @default.
- W2327132091 cites W2133682828 @default.
- W2327132091 cites W2142094348 @default.
- W2327132091 cites W2150077873 @default.
- W2327132091 cites W2152386842 @default.
- W2327132091 cites W2155306696 @default.
- W2327132091 cites W2157134073 @default.
- W2327132091 cites W2164159590 @default.
- W2327132091 cites W2175823523 @default.
- W2327132091 cites W22528786 @default.
- W2327132091 cites W2595614671 @default.
- W2327132091 doi "https://doi.org/10.1021/ab500101c" @default.
- W2327132091 hasPublicationYear "2015" @default.
- W2327132091 type Work @default.
- W2327132091 sameAs 2327132091 @default.
- W2327132091 citedByCount "14" @default.
- W2327132091 countsByYear W23271320912015 @default.
- W2327132091 countsByYear W23271320912016 @default.
- W2327132091 countsByYear W23271320912017 @default.
- W2327132091 countsByYear W23271320912018 @default.
- W2327132091 countsByYear W23271320912019 @default.
- W2327132091 countsByYear W23271320912021 @default.
- W2327132091 crossrefType "journal-article" @default.
- W2327132091 hasAuthorship W2327132091A5000977163 @default.
- W2327132091 hasAuthorship W2327132091A5001051737 @default.