FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327141007> ?p ?o ?g. }

• W2327141007 abstract "The influenza A and B virus genomes comprise eight individual segments of RNA, each encoding one or two proteins essential for virus replication. When two different influenza viruses coinfect the same cell, a mixture of eight genome segments derived from both strains can be incorporated into a single progeny virus. Segment reassortment results in a unique constellation of viral genes that may, in a given host, provide a fitness advantage over viruses encoding either parental genome separately. Reassortment among genetically compatible human and animal influenza A virus segments is believed to be a prerequisite for pandemic influenza.In the laboratory, genome reassortment is easily demonstrated, but the frequency with which reassortment occurs in nature is unknown. Numerous host, viral, and environmental variables can affect the efficiency of influenza virus transmission; thus, in nature, stochastic effects might limit the opportunities for productive host coinfection, and thus reassortment. In a new study, Tao et al . simulated the “natural” spread of influenza viruses in guinea pigs. They infected donor guinea pigs with two genetically similar viruses and then looked for evidence of genome reassortment in guinea pigs that became infected by transmission from the donors. They used optimal transmission conditions to maximize the probability of coinfection in the exposed guinea pig. Even so, they hypothesized that reassortment frequency would be limited by the inherently stochastic nature of inter-host transmission. Surprisingly, however, the authors found that the majority of exposed guinea pigs were productively coinfected by both viruses, whether they were exposed to a single donor guinea pig coinfected with both viruses or to two donors each infected with a different virus. In addition, in coinfected animals, significant segment reassortment was observed; typically, 50 to 100% of progeny viruses isolated from the exposed guinea pigs contained genome segments from both parental variants. Thus, reassortment does not seem to be particularly affected by stochastic effects associated with transmission, at least between genetically similar viruses in guinea pigs.Because pandemic influenza is thought to derive from reassortment between relatively dissimilar strains, the subsequent fitness of a reassorted genome is a critical factor in whether the reassortment spreads worldwide. These results suggest that reassortment likely occurs readily in nature and is probably less limited by coinfection opportunities than by progeny fitness.H. Tao et al ., Influenza A virus co-infection through transmission can support high levels of reassortment. J. Virol. 10.1128/JVI.01162-15 (2015). [[Full Text]][1] [[Abstract]][2] [1]: http://jvi.asm.org/content/early/2015/05/29/JVI.01162-15.long [2]: http://jvi.asm.org/content/early/2015/05/29/JVI.01162-15.abstract" @default.
• W2327141007 created "2016-06-24" @default.
• W2327141007 creator A5091853283 @default.
• W2327141007 date "2015-06-24" @default.
• W2327141007 modified "2023-09-27" @default.
• W2327141007 title "Mixing it up" @default.
• W2327141007 doi "https://doi.org/10.1126/scitranslmed.aac7159" @default.
• W2327141007 hasPublicationYear "2015" @default.
• W2327141007 type Work @default.
• W2327141007 sameAs 2327141007 @default.
• W2327141007 citedByCount "0" @default.
• W2327141007 crossrefType "journal-article" @default.
• W2327141007 hasAuthorship W2327141007A5091853283 @default.
• W2327141007 hasConcept C104317684 @default.
• W2327141007 hasConcept C119599485 @default.
• W2327141007 hasConcept C126831891 @default.
• W2327141007 hasConcept C127413603 @default.
• W2327141007 hasConcept C141231307 @default.
• W2327141007 hasConcept C142724271 @default.
• W2327141007 hasConcept C159047783 @default.
• W2327141007 hasConcept C16154277 @default.
• W2327141007 hasConcept C2522874641 @default.
• W2327141007 hasConcept C2777546802 @default.
• W2327141007 hasConcept C2777813720 @default.
• W2327141007 hasConcept C2779134260 @default.
• W2327141007 hasConcept C3008058167 @default.
• W2327141007 hasConcept C524204448 @default.
• W2327141007 hasConcept C54355233 @default.
• W2327141007 hasConcept C71924100 @default.
• W2327141007 hasConcept C761482 @default.
• W2327141007 hasConcept C86803240 @default.
• W2327141007 hasConcept C8769409 @default.
• W2327141007 hasConceptScore W2327141007C104317684 @default.
• W2327141007 hasConceptScore W2327141007C119599485 @default.
• W2327141007 hasConceptScore W2327141007C126831891 @default.
• W2327141007 hasConceptScore W2327141007C127413603 @default.
• W2327141007 hasConceptScore W2327141007C141231307 @default.
• W2327141007 hasConceptScore W2327141007C142724271 @default.
• W2327141007 hasConceptScore W2327141007C159047783 @default.
• W2327141007 hasConceptScore W2327141007C16154277 @default.
• W2327141007 hasConceptScore W2327141007C2522874641 @default.
• W2327141007 hasConceptScore W2327141007C2777546802 @default.
• W2327141007 hasConceptScore W2327141007C2777813720 @default.
• W2327141007 hasConceptScore W2327141007C2779134260 @default.
• W2327141007 hasConceptScore W2327141007C3008058167 @default.
• W2327141007 hasConceptScore W2327141007C524204448 @default.
• W2327141007 hasConceptScore W2327141007C54355233 @default.
• W2327141007 hasConceptScore W2327141007C71924100 @default.
• W2327141007 hasConceptScore W2327141007C761482 @default.
• W2327141007 hasConceptScore W2327141007C86803240 @default.
• W2327141007 hasConceptScore W2327141007C8769409 @default.
• W2327141007 hasLocation W23271410071 @default.
• W2327141007 hasOpenAccess W2327141007 @default.
• W2327141007 hasPrimaryLocation W23271410071 @default.
• W2327141007 hasRelatedWork W1506302545 @default.
• W2327141007 hasRelatedWork W1597780184 @default.
• W2327141007 hasRelatedWork W1987294917 @default.
• W2327141007 hasRelatedWork W1988047282 @default.
• W2327141007 hasRelatedWork W2017267168 @default.
• W2327141007 hasRelatedWork W2037351257 @default.
• W2327141007 hasRelatedWork W2051925800 @default.
• W2327141007 hasRelatedWork W2133495637 @default.
• W2327141007 hasRelatedWork W2158026876 @default.
• W2327141007 hasRelatedWork W2234768749 @default.
• W2327141007 hasRelatedWork W2288837533 @default.
• W2327141007 hasRelatedWork W2417291671 @default.
• W2327141007 hasRelatedWork W2566537764 @default.
• W2327141007 hasRelatedWork W2599854974 @default.
• W2327141007 hasRelatedWork W2705666013 @default.
• W2327141007 hasRelatedWork W2768072103 @default.
• W2327141007 hasRelatedWork W2772085864 @default.
• W2327141007 hasRelatedWork W3127362961 @default.
• W2327141007 hasRelatedWork W3127879428 @default.
• W2327141007 hasRelatedWork W3180269598 @default.
• W2327141007 isParatext "false" @default.
• W2327141007 isRetracted "false" @default.
• W2327141007 magId "2327141007" @default.
• W2327141007 workType "article" @default.