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- W2327146382 abstract "X-ray crystallography and Cryo-E microscopy have revealed numerous cavities in bacterial ribosomes, not existing in human cytosolic ribosomes [1]. Some of them present features favorable to the binding of antibiotics that disrupt protein synthesis. This is reflected in the large number of ribosome-targeting antibiotics in current clinical use. Nevertheless, the extensive use of antibiotics for over 60 years has led inevitably to the spread of resistant strains. An additional layer of complexity is associated with the high conservation of the structure of functional sites within ribosomal RNA, in particular between prokaryotic and mitochondrial translation machinery, which implies limitations with respect to selectivity and toxicity [2]. Any new strategies to manage antibiotic resistance and reduce side-effects can be addressed through accelerating the development of new drugs and improving safe and appropriate use of antibiotics." @default.
- W2327146382 created "2016-06-24" @default.
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- W2327146382 date "2012-01-01" @default.
- W2327146382 modified "2023-09-27" @default.
- W2327146382 title "The Complexity of Molecular Targeting by Antibiotics Acting on the Ribosome" @default.
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- W2327146382 doi "https://doi.org/10.4172/2161-0711.1000e114" @default.
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