FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327202336> ?p ?o ?g. }

• W2327202336 endingPage "59" @default.
• W2327202336 startingPage "59" @default.
• W2327202336 abstract "Introduction: Chronic allograft injury (CAI) is the most frequent cause of kidney graft loss, and presents with progressive graft impairment. Chemokines, cytokines and MMPs/TIMPs system play the role in fibrosis development. The aim of the study was to assess the importance of MMPs/TIMPs, IL-6 and CCL2 (previously MCP-1) in renal transplant recipients (RTR) with long-term allograft function (over 1 year) with impaired graft function Methods: 150 RTR (male 66%, aged 49,2 ± 11,5 y.), at mean 73,4 ± 41,2 months (range 12-240) after kidney transplantation and 37 healthy volunteers (male 54%, aged 48,4 ± 14,1 y.) as controls, were assessed for plasma and urine MMP-2, MMP-9, TIMP-1, TIMP-2, IL-6 and CCL2. Investigated factors were evaluated by ELISA, and urine concentrations were standardized to urine creatinine. Depending on allograft function 45 RTR had eGFR > 60 ml/min/1,73m2, and 104 RTR had eGFR < 60 ml/min/1,73m2, respectively. The data are presented as mean ± SD or median and 95% Cl for the median. The Mann-Whitney U test (for independent samples) was applied, and differences with p < 0,05 were considered statistically significant. Results: 1. RTR compared with controls had significantly lower eGFR (48 ± 16 and 73 ± 10 ml/min/1,73m2; p = 0,0001) and increased concentrations of plasma and urine IL-6 (p = 1,8e-0,5 and p = 0,0001), MMP-9 (p = 0,0015 and p = 0,003), TIMP-1 (p = 2,2e-16 and p=3,4e-05), TIMP-2 (p = 0,003 and p = 0,02), respectively, as well as lower plasma MMP-2 (p = 7,5e-06) and urine CCL2 (p = 3,3e-05) concentrations. 2. RTR with impaired graft function (eGFR < 60 ml/min/1,73m2) compared with RTR with preserved graft function (eGFR > 60 ml/min/1,73m2) had higher median plasma TIMP-1 (165 ng/ml, 95%Cl 151 - 171 ng/ml vs 124 ng/ml, 95%Cl: 115 - 141 ng/ml; p < 0,0001) and TIMP-2 (93 ng/ml, 95%Cl: 88 - 99 ng/ml vs 79 ng/ml, 95%Cl: 76 - 88 ng/ml; p = 0,0005) concentrations and trend to higher median urine IL-6 concentration (0,9 pg/ml, 95%Cl: 0,6- 1,3 pg/ml vs 0,4 pg/ml, 95%Cl: 0,3 - 0,9 pg/ml; p = 0,054). 3. There were no significant differences in plasma and urine CCL2, MMP-2, MMP-9 and plasma IL-6 concentrations between RTR with preserved and impaired graft function. Conclusion: RTR compared with healthy controls had significantly higher plasma and urine IL-6, urine CCL2 concentrations and unsettled MMPs/TIMPs system RTR with impaired graft function had significantly increased plasma TIMP-1, TIMP-2 and trend to increased urine IL-6 concentrations compared with RTR with preserved graft function." @default.
• W2327202336 created "2016-06-24" @default.
• W2327202336 creator A5002631913 @default.
• W2327202336 creator A5015609743 @default.
• W2327202336 creator A5021590706 @default.
• W2327202336 creator A5034969690 @default.
• W2327202336 creator A5047772306 @default.
• W2327202336 creator A5052494828 @default.
• W2327202336 creator A5053615817 @default.
• W2327202336 creator A5056125023 @default.
• W2327202336 creator A5068371444 @default.
• W2327202336 creator A5070150486 @default.
• W2327202336 date "2012-11-01" @default.
• W2327202336 modified "2023-09-30" @default.
• W2327202336 title "Increased Plasma Timps Concentrations as the Negative Predictor Associated with Deterioration of Kidney Allograft Function in the Long-Term Observation" @default.
• W2327202336 doi "https://doi.org/10.1097/00007890-201211271-00108" @default.
• W2327202336 hasPublicationYear "2012" @default.
• W2327202336 type Work @default.
• W2327202336 sameAs 2327202336 @default.
• W2327202336 citedByCount "1" @default.
• W2327202336 countsByYear W23272023362014 @default.
• W2327202336 crossrefType "journal-article" @default.
• W2327202336 hasAuthorship W2327202336A5002631913 @default.
• W2327202336 hasAuthorship W2327202336A5015609743 @default.
• W2327202336 hasAuthorship W2327202336A5021590706 @default.
• W2327202336 hasAuthorship W2327202336A5034969690 @default.
• W2327202336 hasAuthorship W2327202336A5047772306 @default.
• W2327202336 hasAuthorship W2327202336A5052494828 @default.
• W2327202336 hasAuthorship W2327202336A5053615817 @default.
• W2327202336 hasAuthorship W2327202336A5056125023 @default.
• W2327202336 hasAuthorship W2327202336A5068371444 @default.
• W2327202336 hasAuthorship W2327202336A5070150486 @default.
• W2327202336 hasBestOaLocation W23272023361 @default.
• W2327202336 hasConcept C126322002 @default.
• W2327202336 hasConcept C126894567 @default.
• W2327202336 hasConcept C134018914 @default.
• W2327202336 hasConcept C159641895 @default.
• W2327202336 hasConcept C2778653478 @default.
• W2327202336 hasConcept C2780026642 @default.
• W2327202336 hasConcept C2780091579 @default.
• W2327202336 hasConcept C2780303639 @default.
• W2327202336 hasConcept C2780306776 @default.
• W2327202336 hasConcept C2780559512 @default.
• W2327202336 hasConcept C2911091166 @default.
• W2327202336 hasConcept C71924100 @default.
• W2327202336 hasConcept C90924648 @default.
• W2327202336 hasConceptScore W2327202336C126322002 @default.
• W2327202336 hasConceptScore W2327202336C126894567 @default.
• W2327202336 hasConceptScore W2327202336C134018914 @default.
• W2327202336 hasConceptScore W2327202336C159641895 @default.
• W2327202336 hasConceptScore W2327202336C2778653478 @default.
• W2327202336 hasConceptScore W2327202336C2780026642 @default.
• W2327202336 hasConceptScore W2327202336C2780091579 @default.
• W2327202336 hasConceptScore W2327202336C2780303639 @default.
• W2327202336 hasConceptScore W2327202336C2780306776 @default.
• W2327202336 hasConceptScore W2327202336C2780559512 @default.
• W2327202336 hasConceptScore W2327202336C2911091166 @default.
• W2327202336 hasConceptScore W2327202336C71924100 @default.
• W2327202336 hasConceptScore W2327202336C90924648 @default.
• W2327202336 hasIssue "10S" @default.
• W2327202336 hasLocation W23272023361 @default.
• W2327202336 hasLocation W23272023362 @default.
• W2327202336 hasOpenAccess W2327202336 @default.
• W2327202336 hasPrimaryLocation W23272023361 @default.
• W2327202336 hasRelatedWork W1486584413 @default.
• W2327202336 hasRelatedWork W1977555849 @default.
• W2327202336 hasRelatedWork W2052365623 @default.
• W2327202336 hasRelatedWork W2057091235 @default.
• W2327202336 hasRelatedWork W2063513203 @default.
• W2327202336 hasRelatedWork W2087086071 @default.
• W2327202336 hasRelatedWork W2361025871 @default.
• W2327202336 hasRelatedWork W2392082400 @default.
• W2327202336 hasRelatedWork W3031966738 @default.
• W2327202336 hasRelatedWork W4327521753 @default.
• W2327202336 hasVolume "94" @default.
• W2327202336 isParatext "false" @default.
• W2327202336 isRetracted "false" @default.
• W2327202336 magId "2327202336" @default.
• W2327202336 workType "article" @default.