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• W2327203353 abstract "Objective: To assess retrospective reports of injuries among a population-based cohort of adolescents diagnosed with epilepsy nine years earlier, and compare to that of sibling controls. Background Persons with refractory epilepsy are at increased risk for injuries, but occurrence amongst a representative cohort of children with epilepsy (CWE) including uncomplicated epilepsy (CWUE) at long-term follow-up is unknown. Design/Methods: In a prospective, community-based study of newly diagnosed childhood-onset epilepsy, CWE (n=501) and sibling controls reported whether they had EVER (includes before and after epilepsy diagnosis) experienced certain types of injuries “serious enough to require medical attention,” at 9-year follow-up. Injury rates amongst CWUE (normal neurological exam and IQ≥80) were compared with matched sibling controls (n=210 pairs). Results: Mean age of epilepsy onset was 5.8 years; 49.7% were female. At follow-up, CWE (n=501) were 15.3 years old; 56.9% were ≥5-years seizure-free, 37.5% were taking ≥1 anti-epileptic drug, 76.5% had an IQ≥80 and 87.6% had a normal neurological exam. 49.1% of CWE experienced any injury, of whom 9.3% required surgery/hospitalization and 17.1% had an injury due to a seizure; CWUE (n=368) had lower rates of injury due to a seizure versus those with complicated epilepsy (n=133) (13.6% vs. 27.4%; p≤0.01). Rates of any injury by type (not mutually exclusive) amongst all CWE were: 8% burns/scalds, 25.2% fractures, 24.4% head, 8.4% dental and 10.2% other. CWUE and matched controls (n=210) had a similar rate of any injury (overall and by type) except CWUE had a higher rate of any head injury (30.0% vs. 19.5%; p Conclusions: While nearly half of CWE report ever having an injury requiring medical attention, the rate of injuries amongst CWUE was comparable to that of matched sibling controls, except for having more head injuries. The majority of CWE did not require hospitalization/surgery nor experienced the injury due to a seizure. Supported by: NINDS-R37-NS31146 (PI-Berg). Disclosure: Dr. Baca has nothing to disclose. Dr. Vickrey has received personal compensation for activities with EMD Serono. Dr. Vassar has nothing to disclose. Dr. Cook has nothing to disclose. Dr. Berg has received personal compensation for activities with BIAL as a speaker." @default.
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• W2327203353 date "2012-04-22" @default.
• W2327203353 modified "2023-09-22" @default.
• W2327203353 title "Injuries amongst Adolescents with Childhood-Onset Epilepsy Compared to Sibling Controls (S06.004)" @default.
• W2327203353 doi "https://doi.org/10.1212/wnl.78.1_meetingabstracts.s06.004" @default.
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