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- W2327233242 abstract "L-Phenylalanine was administered intraperitoneally, intravenously, intramuscularly and orally to rats, and its metabolites were separated and identified by high-performance liquid chromatography (HPLC) with fluorescence detection. Chromatographic peaks were identified on the basis of their retention behavior and the assignment of peaks of HPLC was verified by ion-exchange chromatographic analysis. The three metabolites p-, m- and o-tyrosines were formed in vivo after phenylalanine administration. The extents of formation of m- and o-tyrosines were significantly increased by the administration of L-phenylalanine. However, the concentrations of m- and o-tyrosines in the serum were reduced by the administration of α-methyltyrosine, which is an inhibitor of tyrosine hydroxylase. On the other hand, the inhibition of phenylalanine hydroxylase activity by the administration of p-chlorophenylalanine and ethionine resulted in a marked increase of the concentration of phenylalanine in the serum, and the formation of m- and o-tyrosines was also significantly increased. These results suggest that the formation of m- and o-tyrosines from phenylalanine is caused mainly by tyrosine hydroxylase, but not by phenylalanine hydroxylase." @default.
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- W2327233242 date "1986-01-01" @default.
- W2327233242 modified "2023-09-23" @default.
- W2327233242 title "In vivo studies on the formation of m-tyrosine and o-tyrosine from L-phenylalanine in rats." @default.
- W2327233242 cites W2024524034 @default.
- W2327233242 doi "https://doi.org/10.1248/cpb.34.768" @default.
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