FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327237368> ?p ?o ?g. }

• W2327237368 endingPage "1967" @default.
• W2327237368 startingPage "1957" @default.
• W2327237368 abstract "Immunoglobulin light chain (LC) amyloidosis (AL) is caused by deposition of clonal LCs produced by an underlying plasma cell neoplasm. The clonotypic LC sequences are unique to each patient, and they cannot be reliably detected by either immunoassays or standard proteomic workflows that target the constant regions of LCs. We addressed this issue by developing a novel sequence template-based workflow to detect LC variable (LCV) region peptides directly from AL amyloid deposits. The workflow was implemented in a CAP/CLIA compliant clinical laboratory dedicated to proteomic subtyping of amyloid deposits extracted from either formalin-fixed paraffin-embedded tissues or subcutaneous fat aspirates. We evaluated the performance of the workflow on a validation cohort of 30 AL patients, whose amyloidogenic clone was identified using a novel proteogenomics method, and 30 controls. The recall and negative predictive values of the workflow, when identifying the gene family of the AL clone, were 93 and 98%, respectively. Application of the workflow on a clinical cohort of 500 AL amyloidosis samples highlighted a bias in the LCV gene families used by the AL clones. We also detected similarity between AL clones deposited in multiple organs of systemic AL patients. In summary, AL proteomic data sets are rich in LCV region peptides of potential clinical significance that are recoverable with advanced bioinformatics." @default.
• W2327237368 created "2016-06-24" @default.
• W2327237368 creator A5007075478 @default.
• W2327237368 creator A5016663287 @default.
• W2327237368 creator A5024505450 @default.
• W2327237368 creator A5024798837 @default.
• W2327237368 creator A5035511731 @default.
• W2327237368 creator A5035555391 @default.
• W2327237368 creator A5063491403 @default.
• W2327237368 creator A5064721834 @default.
• W2327237368 creator A5065087784 @default.
• W2327237368 creator A5069088013 @default.
• W2327237368 creator A5074099210 @default.
• W2327237368 creator A5081790311 @default.
• W2327237368 creator A5084413271 @default.
• W2327237368 date "2015-03-20" @default.
• W2327237368 modified "2023-09-27" @default.
• W2327237368 title "Proteomic Detection of Immunoglobulin Light Chain Variable Region Peptides from Amyloidosis Patient Biopsies" @default.
• W2327237368 cites W1556901591 @default.
• W2327237368 cites W1965928109 @default.
• W2327237368 cites W1966557933 @default.
• W2327237368 cites W1971887998 @default.
• W2327237368 cites W1978083401 @default.
• W2327237368 cites W1978542424 @default.
• W2327237368 cites W1981593008 @default.
• W2327237368 cites W1982304467 @default.
• W2327237368 cites W1984620312 @default.
• W2327237368 cites W1985806658 @default.
• W2327237368 cites W1990273811 @default.
• W2327237368 cites W1991518289 @default.
• W2327237368 cites W1997280623 @default.
• W2327237368 cites W2009947511 @default.
• W2327237368 cites W2010089695 @default.
• W2327237368 cites W2020973783 @default.
• W2327237368 cites W2026465178 @default.
• W2327237368 cites W2044223958 @default.
• W2327237368 cites W2046882226 @default.
• W2327237368 cites W2053573662 @default.
• W2327237368 cites W2055043387 @default.
• W2327237368 cites W2063939741 @default.
• W2327237368 cites W2066598200 @default.
• W2327237368 cites W2081465448 @default.
• W2327237368 cites W2082006641 @default.
• W2327237368 cites W2093464694 @default.
• W2327237368 cites W2096057003 @default.
• W2327237368 cites W2105273832 @default.
• W2327237368 cites W2127143454 @default.
• W2327237368 cites W2157778290 @default.
• W2327237368 cites W2158164551 @default.
• W2327237368 cites W2326414500 @default.
• W2327237368 cites W4205498725 @default.
• W2327237368 cites W4247053599 @default.
• W2327237368 doi "https://doi.org/10.1021/acs.jproteome.5b00015" @default.
• W2327237368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25734799" @default.
• W2327237368 hasPublicationYear "2015" @default.
• W2327237368 type Work @default.
• W2327237368 sameAs 2327237368 @default.
• W2327237368 citedByCount "47" @default.
• W2327237368 countsByYear W23272373682015 @default.
• W2327237368 countsByYear W23272373682016 @default.
• W2327237368 countsByYear W23272373682017 @default.
• W2327237368 countsByYear W23272373682018 @default.
• W2327237368 countsByYear W23272373682019 @default.
• W2327237368 countsByYear W23272373682020 @default.
• W2327237368 countsByYear W23272373682021 @default.
• W2327237368 countsByYear W23272373682022 @default.
• W2327237368 countsByYear W23272373682023 @default.
• W2327237368 crossrefType "journal-article" @default.
• W2327237368 hasAuthorship W2327237368A5007075478 @default.
• W2327237368 hasAuthorship W2327237368A5016663287 @default.
• W2327237368 hasAuthorship W2327237368A5024505450 @default.
• W2327237368 hasAuthorship W2327237368A5024798837 @default.
• W2327237368 hasAuthorship W2327237368A5035511731 @default.
• W2327237368 hasAuthorship W2327237368A5035555391 @default.
• W2327237368 hasAuthorship W2327237368A5063491403 @default.
• W2327237368 hasAuthorship W2327237368A5064721834 @default.
• W2327237368 hasAuthorship W2327237368A5065087784 @default.
• W2327237368 hasAuthorship W2327237368A5069088013 @default.
• W2327237368 hasAuthorship W2327237368A5074099210 @default.
• W2327237368 hasAuthorship W2327237368A5081790311 @default.
• W2327237368 hasAuthorship W2327237368A5084413271 @default.
• W2327237368 hasConcept C104317684 @default.
• W2327237368 hasConcept C141231307 @default.
• W2327237368 hasConcept C142724271 @default.
• W2327237368 hasConcept C145741570 @default.
• W2327237368 hasConcept C159654299 @default.
• W2327237368 hasConcept C177212765 @default.
• W2327237368 hasConcept C189206191 @default.
• W2327237368 hasConcept C199360897 @default.
• W2327237368 hasConcept C203014093 @default.
• W2327237368 hasConcept C2779551797 @default.
• W2327237368 hasConcept C2779951007 @default.
• W2327237368 hasConcept C36394416 @default.
• W2327237368 hasConcept C41008148 @default.
• W2327237368 hasConcept C55493867 @default.
• W2327237368 hasConcept C70721500 @default.
• W2327237368 hasConcept C71924100 @default.
• W2327237368 hasConcept C77088390 @default.

• next