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• W2327249912 endingPage "4170" @default.
• W2327249912 startingPage "4164" @default.
• W2327249912 abstract "The anti-tumor promotional effects of t9,t11-conjugated linoleic acid (t9,t11-CLA) and t10,t12-CLA were evaluated on the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inhibition of gap junctional intercellular communication (GJIC) in the human mammary epithelial cell line MCF-10A. The results were compared to those obtained from c9,t11-CLA, which is a more effective anti-tumor promoter on TPA-induced GJIC inhibition in MCF-10A cells than t10,c12-CLA. Cells were treated with 20 μM t9,t11-CLA, t10,t12-CLA, or c9,t11-CLA for 24 h followed by 60 nM TPA for 1 h. Both t9,t11-CLA and t10,t12-CLA equally protected MCF-10A cells from TPA-induced inhibition of GJIC with inferior efficacy to c9,t11-CLA.The protection was due to the ameliorated phosphorylation of connexin43 via suppression of extracellular signal-regulated kinases (ERK1/2) activation. Suppression of TPA-induced reactive oxygen species (ROS) generation by t9,t11-CLA and t10,t12-CLA was less effective, relative to c9,t11-CLA. The results suggest that the anti-promotional activities of t9,t11-CLA and t10,t12-CLA are equal but less potent than c9,t11-CLA in TPA-treated MCF-10A cells. The activity might be mediated by the attenuation of ROS production in MCF-10A cells by preventing the downregulation of GJIC during the cancer promotion stage." @default.
• W2327249912 created "2016-06-24" @default.
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• W2327249912 date "2011-03-10" @default.
• W2327249912 modified "2023-10-07" @default.
• W2327249912 title "Preventive Effect of <i>t</i>,<i>t</i>-Conjugated Linoleic Acid on 12-<i>O</i>-Tetradecanoylphorbol-13-acetate-Induced Inhibition of Gap Junctional Intercellular Communication in Human Mammary Epithelial MCF-10A Cells" @default.
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• W2327249912 doi "https://doi.org/10.1021/jf1046909" @default.
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