Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327277039> ?p ?o ?g. }
- W2327277039 endingPage "6024" @default.
- W2327277039 startingPage "6016" @default.
- W2327277039 abstract "This paper describes a metabonomic study of prenatal disorders using nuclear magnetic resonance (NMR) spectroscopy of amniotic fluid (AF) collected in the second trimester of pregnancy, to search for metabolite markers of fetal malformations, prediagnostic gestational diabetes (GD), preterm delivery (PTD), early rupture of membranes (PROM), and chromossomopathies. Fetal malformations were found to have the highest impact on AF metabolite composition, enabling statistical validation to be achieved by several multivariate analytical tools. Results confirmed previous indications that malformed fetuses seem to suffer altered energy metabolism and kidney underdevelopment. Newly found changes (namely in α-oxoisovalerate, ascorbate, creatinine, isoleucine, serine, threonine) suggest possible additional effects on protein and nucleotide sugar biosynthesis. Prediagnostic GD subjects showed an average increase in glucose and small decreases in several amino acids along with acetate, formate, creatinine, and glycerophosphocholine. Small metabolite changes were also observed in the AF of subjects eventually undergoing PTD and PROM, whereas no relevant changes were found for chromossomopathies (for which a low number of samples was considered). The potential value of these results for biochemical insight and prediction of prenatal disorders is discussed, as well as their limitations regarding number of samples and overlap of different disorders." @default.
- W2327277039 created "2016-06-24" @default.
- W2327277039 creator A5004819659 @default.
- W2327277039 creator A5006694116 @default.
- W2327277039 creator A5020155386 @default.
- W2327277039 creator A5026287635 @default.
- W2327277039 creator A5031112172 @default.
- W2327277039 creator A5051999472 @default.
- W2327277039 creator A5058692205 @default.
- W2327277039 creator A5059458759 @default.
- W2327277039 creator A5061229012 @default.
- W2327277039 creator A5081991561 @default.
- W2327277039 date "2010-10-11" @default.
- W2327277039 modified "2023-10-18" @default.
- W2327277039 title "Impact of Prenatal Disorders on the Metabolic Profile of Second Trimester Amniotic Fluid: A Nuclear Magnetic Resonance Metabonomic Study" @default.
- W2327277039 cites W1953615440 @default.
- W2327277039 cites W1967144552 @default.
- W2327277039 cites W1968813633 @default.
- W2327277039 cites W1984298279 @default.
- W2327277039 cites W1993245972 @default.
- W2327277039 cites W1993832260 @default.
- W2327277039 cites W2003414488 @default.
- W2327277039 cites W2006565594 @default.
- W2327277039 cites W2007767580 @default.
- W2327277039 cites W2007808016 @default.
- W2327277039 cites W2008777167 @default.
- W2327277039 cites W2012743472 @default.
- W2327277039 cites W2022985221 @default.
- W2327277039 cites W2027596874 @default.
- W2327277039 cites W2034030065 @default.
- W2327277039 cites W2036381691 @default.
- W2327277039 cites W2036702081 @default.
- W2327277039 cites W2050062639 @default.
- W2327277039 cites W2057111689 @default.
- W2327277039 cites W2058352802 @default.
- W2327277039 cites W2060952451 @default.
- W2327277039 cites W2067679994 @default.
- W2327277039 cites W2074518678 @default.
- W2327277039 cites W2075645722 @default.
- W2327277039 cites W2078026171 @default.
- W2327277039 cites W2082117719 @default.
- W2327277039 cites W2082383849 @default.
- W2327277039 cites W2083281965 @default.
- W2327277039 cites W2086948997 @default.
- W2327277039 cites W2088834358 @default.
- W2327277039 cites W2089309220 @default.
- W2327277039 cites W2090785462 @default.
- W2327277039 cites W2094438647 @default.
- W2327277039 cites W2120968905 @default.
- W2327277039 cites W2131137838 @default.
- W2327277039 cites W2166059050 @default.
- W2327277039 doi "https://doi.org/10.1021/pr100815q" @default.
- W2327277039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20849080" @default.
- W2327277039 hasPublicationYear "2010" @default.
- W2327277039 type Work @default.
- W2327277039 sameAs 2327277039 @default.
- W2327277039 citedByCount "89" @default.
- W2327277039 countsByYear W23272770392012 @default.
- W2327277039 countsByYear W23272770392013 @default.
- W2327277039 countsByYear W23272770392014 @default.
- W2327277039 countsByYear W23272770392015 @default.
- W2327277039 countsByYear W23272770392016 @default.
- W2327277039 countsByYear W23272770392017 @default.
- W2327277039 countsByYear W23272770392018 @default.
- W2327277039 countsByYear W23272770392019 @default.
- W2327277039 countsByYear W23272770392020 @default.
- W2327277039 countsByYear W23272770392021 @default.
- W2327277039 countsByYear W23272770392022 @default.
- W2327277039 countsByYear W23272770392023 @default.
- W2327277039 crossrefType "journal-article" @default.
- W2327277039 hasAuthorship W2327277039A5004819659 @default.
- W2327277039 hasAuthorship W2327277039A5006694116 @default.
- W2327277039 hasAuthorship W2327277039A5020155386 @default.
- W2327277039 hasAuthorship W2327277039A5026287635 @default.
- W2327277039 hasAuthorship W2327277039A5031112172 @default.
- W2327277039 hasAuthorship W2327277039A5051999472 @default.
- W2327277039 hasAuthorship W2327277039A5058692205 @default.
- W2327277039 hasAuthorship W2327277039A5059458759 @default.
- W2327277039 hasAuthorship W2327277039A5061229012 @default.
- W2327277039 hasAuthorship W2327277039A5081991561 @default.
- W2327277039 hasConcept C126322002 @default.
- W2327277039 hasConcept C134018914 @default.
- W2327277039 hasConcept C135870905 @default.
- W2327277039 hasConcept C172680121 @default.
- W2327277039 hasConcept C185592680 @default.
- W2327277039 hasConcept C2776580952 @default.
- W2327277039 hasConcept C2777305461 @default.
- W2327277039 hasConcept C2777477808 @default.
- W2327277039 hasConcept C2778194526 @default.
- W2327277039 hasConcept C2779234561 @default.
- W2327277039 hasConcept C2780306776 @default.
- W2327277039 hasConcept C515207424 @default.
- W2327277039 hasConcept C54355233 @default.
- W2327277039 hasConcept C55493867 @default.
- W2327277039 hasConcept C71924100 @default.
- W2327277039 hasConcept C86803240 @default.
- W2327277039 hasConceptScore W2327277039C126322002 @default.
- W2327277039 hasConceptScore W2327277039C134018914 @default.