FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327283708> ?p ?o ?g. }

• W2327283708 endingPage "1549" @default.
• W2327283708 startingPage "1542" @default.
• W2327283708 abstract "Recent studies have suggested that platelet-rich plasma (PRP) injections are an effective way to retard intervertebral disc degeneration, but the mechanism of action is unclear. Activated platelets release some growth factors, such as transforming growth factor-β1 (TGF-β1), which positively modulate the extracellular matrix of nucleus pulposus cells. The purpose of this study was to explore the mechanism underlying the PRP-mediated inhibition of intervertebral disc degeneration. In an in vitro study, we found that the proliferation of nucleus pulposus cells was greatly enhanced with 2.5% PRP treatment. The TGF-β1 concentration was much higher after PRP treatment. PRP administration effectively increased the collagen II, aggrecan and sox-9 mRNA levels and decreased collagen X levels. However, Western blotting demonstrated that specifically inhibiting TGF-β1 signalling could significantly prevent nucleus pulpous cellular expression of Smad2/3 and matrix protein. In a rabbit study, magnetic resonance imaging revealed significant recovery signal intensity in the intervertebral discs of the PRP injection group compared with the very low signal intensity in the control groups. Histologically, the PRP plus inhibitor injection group had significantly lower expression levels of Smad2/3 and collagen II than the PRP group. These results demonstrated that a high TGF-β1 content in the platelets retarded disc degeneration in vitro and in vivo. Inhibiting the TGF-β1/Smad2/3 pathway could prevent this recovery by inactivating Smad2/3 and down-regulating the extracellular matrix. Therefore, the TGF-β1/Smad2/3 pathway might play a critical role in the ability of PRP to retard intervertebral disc degeneration." @default.
• W2327283708 created "2016-06-24" @default.
• W2327283708 creator A5006169234 @default.
• W2327283708 creator A5019577028 @default.
• W2327283708 creator A5026065808 @default.
• W2327283708 creator A5035635459 @default.
• W2327283708 creator A5042318166 @default.
• W2327283708 creator A5047054215 @default.
• W2327283708 creator A5051862250 @default.
• W2327283708 creator A5076355116 @default.
• W2327283708 date "2016-04-06" @default.
• W2327283708 modified "2023-10-14" @default.
• W2327283708 title "The role of <scp>TGF</scp>‐β1/Smad2/3 pathway in platelet‐rich plasma in retarding intervertebral disc degeneration" @default.
• W2327283708 cites W1533220576 @default.
• W2327283708 cites W1550333213 @default.
• W2327283708 cites W1815558303 @default.
• W2327283708 cites W1995011008 @default.
• W2327283708 cites W1997432933 @default.
• W2327283708 cites W2006050540 @default.
• W2327283708 cites W2015625211 @default.
• W2327283708 cites W2019143624 @default.
• W2327283708 cites W2035765664 @default.
• W2327283708 cites W2040181572 @default.
• W2327283708 cites W2050891920 @default.
• W2327283708 cites W2064563396 @default.
• W2327283708 cites W207290846 @default.
• W2327283708 cites W2136871488 @default.
• W2327283708 cites W2139345084 @default.
• W2327283708 cites W2141651735 @default.
• W2327283708 cites W2143018793 @default.
• W2327283708 doi "https://doi.org/10.1111/jcmm.12847" @default.
• W2327283708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4956937" @default.
• W2327283708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27061332" @default.
• W2327283708 hasPublicationYear "2016" @default.
• W2327283708 type Work @default.
• W2327283708 sameAs 2327283708 @default.
• W2327283708 citedByCount "38" @default.
• W2327283708 countsByYear W23272837082017 @default.
• W2327283708 countsByYear W23272837082018 @default.
• W2327283708 countsByYear W23272837082019 @default.
• W2327283708 countsByYear W23272837082020 @default.
• W2327283708 countsByYear W23272837082021 @default.
• W2327283708 countsByYear W23272837082022 @default.
• W2327283708 countsByYear W23272837082023 @default.
• W2327283708 crossrefType "journal-article" @default.
• W2327283708 hasAuthorship W2327283708A5006169234 @default.
• W2327283708 hasAuthorship W2327283708A5019577028 @default.
• W2327283708 hasAuthorship W2327283708A5026065808 @default.
• W2327283708 hasAuthorship W2327283708A5035635459 @default.
• W2327283708 hasAuthorship W2327283708A5042318166 @default.
• W2327283708 hasAuthorship W2327283708A5047054215 @default.
• W2327283708 hasAuthorship W2327283708A5051862250 @default.
• W2327283708 hasAuthorship W2327283708A5076355116 @default.
• W2327283708 hasBestOaLocation W23272837081 @default.
• W2327283708 hasConcept C105702510 @default.
• W2327283708 hasConcept C106487976 @default.
• W2327283708 hasConcept C118131993 @default.
• W2327283708 hasConcept C126322002 @default.
• W2327283708 hasConcept C142724271 @default.
• W2327283708 hasConcept C150903083 @default.
• W2327283708 hasConcept C185592680 @default.
• W2327283708 hasConcept C189165786 @default.
• W2327283708 hasConcept C197534660 @default.
• W2327283708 hasConcept C202751555 @default.
• W2327283708 hasConcept C204787440 @default.
• W2327283708 hasConcept C207001950 @default.
• W2327283708 hasConcept C2776164576 @default.
• W2327283708 hasConcept C2777755357 @default.
• W2327283708 hasConcept C2780076745 @default.
• W2327283708 hasConcept C3020332539 @default.
• W2327283708 hasConcept C43617362 @default.
• W2327283708 hasConcept C55493867 @default.
• W2327283708 hasConcept C62478195 @default.
• W2327283708 hasConcept C71924100 @default.
• W2327283708 hasConcept C86803240 @default.
• W2327283708 hasConcept C89560881 @default.
• W2327283708 hasConcept C95444343 @default.
• W2327283708 hasConceptScore W2327283708C105702510 @default.
• W2327283708 hasConceptScore W2327283708C106487976 @default.
• W2327283708 hasConceptScore W2327283708C118131993 @default.
• W2327283708 hasConceptScore W2327283708C126322002 @default.
• W2327283708 hasConceptScore W2327283708C142724271 @default.
• W2327283708 hasConceptScore W2327283708C150903083 @default.
• W2327283708 hasConceptScore W2327283708C185592680 @default.
• W2327283708 hasConceptScore W2327283708C189165786 @default.
• W2327283708 hasConceptScore W2327283708C197534660 @default.
• W2327283708 hasConceptScore W2327283708C202751555 @default.
• W2327283708 hasConceptScore W2327283708C204787440 @default.
• W2327283708 hasConceptScore W2327283708C207001950 @default.
• W2327283708 hasConceptScore W2327283708C2776164576 @default.
• W2327283708 hasConceptScore W2327283708C2777755357 @default.
• W2327283708 hasConceptScore W2327283708C2780076745 @default.
• W2327283708 hasConceptScore W2327283708C3020332539 @default.
• W2327283708 hasConceptScore W2327283708C43617362 @default.
• W2327283708 hasConceptScore W2327283708C55493867 @default.
• W2327283708 hasConceptScore W2327283708C62478195 @default.
• W2327283708 hasConceptScore W2327283708C71924100 @default.
• W2327283708 hasConceptScore W2327283708C86803240 @default.

• next