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• W2327295012 abstract "In Brief Objectives To assess the risk of endometrial cancer (EC) associated with atypical glandular cells of endometrial origin (AGC-EM) in 2 age groups (age younger than 51 vs 51 years or older). Methods A retrospective case series was assembled identifying AGC from a pathology database between January 1, 2005 and January 1, 2009. Demographics, cervical cytology results, and final diagnoses (including clinically significant diseases and cancers) were recorded from the initial AGC diagnosis until August 30, 2011. Data were analyzed using the χ2 test to compare rates of disease between age groups. Results Among the 444 patients with AGC, 41% (183/444) had AGC-EM. Women younger than 51 years, compared to those 51 years or older, had significantly lower rates of AGC-EM (35% [105/296] vs 53% [78/148]; p < .001; odds ratio, 0.49; 95% confidence interval, 0.33–0.74). The rate of EC was significantly lower in those younger than 51 years, compared to those aged 51 or older (5% [8/158] vs 19% [18/95]; p < .001; odds ratio, 0.23; 95% confidence interval, 0.09–0.55) in women who underwent endometrial biopsy. In women younger than 51 years who underwent an endometrial biopsy, the rate of EC had a stepwise increase across 3 subclasses of AGC (from AGC of endocervical origin [AGC-EC] to AGC not otherwise specified to AGC-EM) (p = .04). Conclusions Women aged 51 years or older who have AGC are more likely to have AGC-EM and EC than women younger than 51 years. In women younger than age 51, AGC-EM is the subclass most associated with EC while compared to 2 other subclasses (AGC not otherwise specified and AGC-EC). Women 51 years of age or older with atypical glandular cells of endometrial origin had a higher risk of endometrial cancer than those younger than 51 years. However, atypical glandular cells of endometrial origin was the subclass most frequently associated with endometrial cancer in women younger than 51 years." @default.
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• W2327295012 date "2015-07-01" @default.
• W2327295012 modified "2023-10-18" @default.
• W2327295012 title "Atypical Glandular Cells of Endometrial Origin and the Risk of Endometrial Cancer" @default.
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• W2327295012 doi "https://doi.org/10.1097/lgt.0000000000000105" @default.
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