Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327382491> ?p ?o ?g. }
- W2327382491 endingPage "267" @default.
- W2327382491 startingPage "261" @default.
- W2327382491 abstract "Pioglitazone (PGZ), a synthetic peroxisome proliferator-activated receptor γ agonist, is known to regulate inflammatory process and to have neuroprotective effects against neurological disorders. In the present study, we examined the effects of 30 mg/kg PGZ on excitotoxic neuronal damage and glial activation in the mouse hippocampus following intracerebroventricular injection of kainic acid (KA). PGZ treatment significantly reduced seizure-like behavior. PGZ had the neuroprotective effect against KA-induced neuronal damage and attenuated the activations of astrocytes and microglia in the hippocampal CA3 region. In addition, MPO and NFκB immunoreactivities in the glial cells were also decreased in the PGZ-treated group. These results indicate that PGZ had anticonvulsant and neuroprotective effects against KA-induced excitotocix injury, and that neuroprotective effect of PGZ might be due to the attenuation of KA-induced activation in astrocytes and microglia as well as KA-induced increases in MPO and NFκB." @default.
- W2327382491 created "2016-06-24" @default.
- W2327382491 creator A5013947041 @default.
- W2327382491 creator A5047765987 @default.
- W2327382491 creator A5049466193 @default.
- W2327382491 creator A5061900460 @default.
- W2327382491 creator A5077093336 @default.
- W2327382491 creator A5080776667 @default.
- W2327382491 date "2015-05-31" @default.
- W2327382491 modified "2023-09-23" @default.
- W2327382491 title "Effect of Pioglitazone on Excitotoxic Neuronal Damage in the Mouse Hippocampus" @default.
- W2327382491 cites W1545110321 @default.
- W2327382491 cites W1574784740 @default.
- W2327382491 cites W1843854943 @default.
- W2327382491 cites W1965820739 @default.
- W2327382491 cites W1965898722 @default.
- W2327382491 cites W1970899762 @default.
- W2327382491 cites W1971960602 @default.
- W2327382491 cites W1974297132 @default.
- W2327382491 cites W1976033734 @default.
- W2327382491 cites W1977951553 @default.
- W2327382491 cites W1978380407 @default.
- W2327382491 cites W1989020899 @default.
- W2327382491 cites W1989980596 @default.
- W2327382491 cites W1994587405 @default.
- W2327382491 cites W2000523742 @default.
- W2327382491 cites W2021072711 @default.
- W2327382491 cites W2022197180 @default.
- W2327382491 cites W2033104900 @default.
- W2327382491 cites W2033488453 @default.
- W2327382491 cites W2036991120 @default.
- W2327382491 cites W2038781543 @default.
- W2327382491 cites W2040252933 @default.
- W2327382491 cites W2042828511 @default.
- W2327382491 cites W2058464768 @default.
- W2327382491 cites W2058693141 @default.
- W2327382491 cites W2059030487 @default.
- W2327382491 cites W2059552796 @default.
- W2327382491 cites W2060678630 @default.
- W2327382491 cites W2068597324 @default.
- W2327382491 cites W2070168780 @default.
- W2327382491 cites W2071992832 @default.
- W2327382491 cites W2081689918 @default.
- W2327382491 cites W2082789085 @default.
- W2327382491 cites W2085701678 @default.
- W2327382491 cites W2127231794 @default.
- W2327382491 cites W2128463839 @default.
- W2327382491 cites W2137936645 @default.
- W2327382491 cites W2138910310 @default.
- W2327382491 cites W2142360514 @default.
- W2327382491 cites W2167409304 @default.
- W2327382491 cites W2427880780 @default.
- W2327382491 cites W2573540928 @default.
- W2327382491 doi "https://doi.org/10.4062/biomolther.2014.146" @default.
- W2327382491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4428719" @default.
- W2327382491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25995825" @default.
- W2327382491 hasPublicationYear "2015" @default.
- W2327382491 type Work @default.
- W2327382491 sameAs 2327382491 @default.
- W2327382491 citedByCount "7" @default.
- W2327382491 countsByYear W23273824912017 @default.
- W2327382491 countsByYear W23273824912019 @default.
- W2327382491 countsByYear W23273824912020 @default.
- W2327382491 countsByYear W23273824912022 @default.
- W2327382491 countsByYear W23273824912023 @default.
- W2327382491 crossrefType "journal-article" @default.
- W2327382491 hasAuthorship W2327382491A5013947041 @default.
- W2327382491 hasAuthorship W2327382491A5047765987 @default.
- W2327382491 hasAuthorship W2327382491A5049466193 @default.
- W2327382491 hasAuthorship W2327382491A5061900460 @default.
- W2327382491 hasAuthorship W2327382491A5077093336 @default.
- W2327382491 hasAuthorship W2327382491A5080776667 @default.
- W2327382491 hasBestOaLocation W23273824912 @default.
- W2327382491 hasConcept C126322002 @default.
- W2327382491 hasConcept C134018914 @default.
- W2327382491 hasConcept C148762608 @default.
- W2327382491 hasConcept C169760540 @default.
- W2327382491 hasConcept C170493617 @default.
- W2327382491 hasConcept C185592680 @default.
- W2327382491 hasConcept C25498285 @default.
- W2327382491 hasConcept C2776108384 @default.
- W2327382491 hasConcept C2776914184 @default.
- W2327382491 hasConcept C2777180221 @default.
- W2327382491 hasConcept C2778384471 @default.
- W2327382491 hasConcept C2778938600 @default.
- W2327382491 hasConcept C2779830541 @default.
- W2327382491 hasConcept C2781012912 @default.
- W2327382491 hasConcept C555293320 @default.
- W2327382491 hasConcept C61174792 @default.
- W2327382491 hasConcept C71924100 @default.
- W2327382491 hasConcept C86803240 @default.
- W2327382491 hasConcept C98274493 @default.
- W2327382491 hasConceptScore W2327382491C126322002 @default.
- W2327382491 hasConceptScore W2327382491C134018914 @default.
- W2327382491 hasConceptScore W2327382491C148762608 @default.
- W2327382491 hasConceptScore W2327382491C169760540 @default.
- W2327382491 hasConceptScore W2327382491C170493617 @default.
- W2327382491 hasConceptScore W2327382491C185592680 @default.