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• W2327388839 endingPage "1823" @default.
• W2327388839 startingPage "1819" @default.
• W2327388839 abstract "Bacterial biofilms are organized communities of microorganisms, embedded in a self-produced matrix, growing on a biotic surface and resistant to many antimicrobial agents when associated with a medical device. These biofilms require the development of new strategies for the prevention and treatment of infectious disease, including the potential use of natural products. One interesting natural product example is Hypericum, a plant genus that contains species known to have antimicrobial properties. The major constituent of Hypericum perforatum is an unstable compound named hyperforin (1); for this reason it was not believed to play a significant role in the pharmacological effects. In this investigation a hydrogenated hyperforin analogue (2) was tested on several ATCC and clinical isolate strains, in their planktonic and biofilm form (Staphylococcus aureus, MRSA, and Enterococcus faecalis). Compound 2 was effective against planktonic and biofilm cultures, probably due to higher stability, showing the percentage of cells killed in the range from 45% to 52%. These results are noteworthy from the point of view of future development of these polyprenylated phloroglucinols as potential antibiotics." @default.
• W2327388839 created "2016-06-24" @default.
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• W2327388839 date "2013-08-27" @default.
• W2327388839 modified "2023-10-17" @default.
• W2327388839 title "Biological Evaluation of Hyperforin and Its Hydrogenated Analogue on Bacterial Growth and Biofilm Production" @default.
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• W2327388839 doi "https://doi.org/10.1021/np400394c" @default.
• W2327388839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23981190" @default.
• W2327388839 hasPublicationYear "2013" @default.
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