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- W2327424057 abstract "To evaluate the drug release from a suppository by the designed dialysis tubing apparatus, commercially available indomethacin and sodium diclofenac suppositories were used.A dialysis tubing, in which a suppository was put, was immersed in the release fluid maintained at 37.0±0.3°C, and the release amount of drug released across the dialysis tubing was determined.The release rate of both drugs across the dialysis tubing of 70Å of pore size was faster than that of 25Å of pore size.In the case of fatty base, the drug diffusion through the dialysis tubing was constant when the length of dialysis tubing contacting with the release fluid was more than 7.0cm.The suitable rotation speed in the release fluid was 50rpm considering small variation in the released amounts.The proposed dialysis tubing method should offer a useful means of measuring the drug release from suppository and the reproducibility of the release curves was acceptable." @default.
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- W2327424057 date "1988-01-01" @default.
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- W2327424057 title "Design of drug release apparatus with dialysis tubing from suppository." @default.
- W2327424057 doi "https://doi.org/10.5649/jjphcs1975.14.307" @default.
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