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- W2327430129 abstract "Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate in the synthesis of methionine from homocysteine. We have cloned and characterized two Aspergillus nidulans genes encoding MTHFRs: metA and metF. Mutations in either gene result in methionine requirement; the metA-encoded enzyme is responsible for only 10–15% of total MTHFR activity. These two enzymes belong to different classes of MTHFRs. Mutations in metA but not in the metF gene are suppressed by mutations resulting in enhancement of homocysteine synthesis. The expression of both genes is up-regulated by homocysteine." @default.
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- W2327430129 date "2012-10-01" @default.
- W2327430129 modified "2023-09-25" @default.
- W2327430129 title "P.3.c.037 Antipsychotic polypharmacy in the treatment of patients with related psychosis: combined cross-sectional and long-term follow up study" @default.
- W2327430129 doi "https://doi.org/10.1016/s0924-977x(12)70521-7" @default.
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