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- W2327496543 abstract "SummaryThe mechanism of enhanced interaction of T-L with SRBC-A has been explored and the following results obtained: (1) Compared with SRBC, SRBC-A contain identical quantities of protein, phos-pholipid, and sialic acid, but have slightly reduced SH content; (2) treatment of SRBC with thiols having charge properties different from AET also facilitates rosetting; (3) exposure of SRBC to various SH-alkylating reagents, either before or after thiol treatment, does not diminish thiol-enhanced rosetting; (4) trypsinization of SRBC and of SRBC-A completely abolishes the ability of these cells to rosette; and (5) no differences could be detected between intact SRBC and SRBC-A, or in their solubilized membrane components, by SDS-PAGE and by ESR. These results indicate that free SH groups of SRBC membranes are not directly involved in the rosetting process. Thiol-enhanced rosetting probably results from cleavage of membrane S-S bridges resulting in configu-rational changes within the SRBC membrane. The interactio..." @default.
- W2327496543 created "2016-06-24" @default.
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- W2327496543 date "1976-10-01" @default.
- W2327496543 modified "2023-09-26" @default.
- W2327496543 title "Effects of Thiols on Sheep Erythrocytes Resulting in Enhanced Rosette Formation with Human T Lymphocytes" @default.
- W2327496543 doi "https://doi.org/10.3181/00379727-153-39489" @default.
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