Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327501875> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2327501875 abstract "BACKGROUND: Inflammatory breast cancer (IBC) is the most aggressive form of invasive breast cancer and is associated with poor outcome in spite of optimal multidisciplinary management. The disease is associated poor response to neoadjuvant chemotherapy and a peculiar pattern of recurrence (chest wall, nodes, CNS). There currently few distinct molecular alterations for effective therapeutic targeting in the advance setting. The availability of comprehensive cancer genomic testing using Next-Generation Sequencing (NGS) technology may identify a number of genomic alterations not assessed by traditional methods and provide opportunities for more effective treatment selection particularly in aggressive and uncommon diseases such as IBC.METHODS: Twenty-three patients with refractory metastatic IBC were included in this analysis. All patients underwent confirmatory biopsy and/or tissue collection. Tissue from metastastic lesions of patients with recurrent IBC was submitted as slides or FFPE blocks. NGS was performed by Foundation Medicine, Cambridge, MA. The entire coding sequence of 182 cancer-related genes (3,230 exons) plus 37 introns from 14 genes often rearranged in cancer were sequenced to high depth (>500X) All classes of genomic alterations were detected.RESULTS: The site distribution and frequency of disease recurrence included: soft tissue (19) lung (4), bone and liver (3), and brain (2). The disease subtype classification based on the expression of ER, PR and HER-2 were as follow: ER−, PR−, Her-2−, Basal-like or TN (65%); ER+ and/or PR+, HER-2− (grade3) or HER-2+, Luminal B (22%); ER−, PR−, HER2+ (13%). Genomic alterations were identified in all patients with various frequencies. Genetic mutations included: P53 (DNA-binding domain, splice site), PI3KCA (H1047R, R441N, E545K, K111E,); RB1; PTEN (D107Y); EGFR (L858R); ERBB2 (V777L, S310F) in a patient with TN disease; ESR1 D538G. Gene amplifications included: MYC (26%); CCND1 (22%); ERBB2 (in a patient with TN disease), MLC-1, CCNE1, CK4, K-RAS. One patient had evidence of discordant genomic abnormalities in two simultaneous sites of recurrence (skin and pleura) suggesting disease heterogeneity. Three patients were effectively treated with genomic alterations-guided therapies.CONCLUSIONS: Genomic sequencing of advanced IBC is feasible, identifies potential therapeutic targets and can advance our understanding of the molecular alterations of this aggressive disease.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr PD05-01." @default.
- W2327501875 created "2016-06-24" @default.
- W2327501875 creator A5010821072 @default.
- W2327501875 creator A5029117265 @default.
- W2327501875 creator A5029183165 @default.
- W2327501875 creator A5032987754 @default.
- W2327501875 creator A5039181152 @default.
- W2327501875 creator A5061636658 @default.
- W2327501875 creator A5064522118 @default.
- W2327501875 creator A5082609665 @default.
- W2327501875 date "2012-12-15" @default.
- W2327501875 modified "2023-09-27" @default.
- W2327501875 title "Abstract PD05-01: Next generation genomic sequencing (NGS) identifies molecular targets in inflammatory breast cancer (IBC)" @default.
- W2327501875 doi "https://doi.org/10.1158/0008-5472.sabcs12-pd05-01" @default.
- W2327501875 hasPublicationYear "2012" @default.
- W2327501875 type Work @default.
- W2327501875 sameAs 2327501875 @default.
- W2327501875 citedByCount "0" @default.
- W2327501875 crossrefType "proceedings-article" @default.
- W2327501875 hasAuthorship W2327501875A5010821072 @default.
- W2327501875 hasAuthorship W2327501875A5029117265 @default.
- W2327501875 hasAuthorship W2327501875A5029183165 @default.
- W2327501875 hasAuthorship W2327501875A5032987754 @default.
- W2327501875 hasAuthorship W2327501875A5039181152 @default.
- W2327501875 hasAuthorship W2327501875A5061636658 @default.
- W2327501875 hasAuthorship W2327501875A5064522118 @default.
- W2327501875 hasAuthorship W2327501875A5082609665 @default.
- W2327501875 hasConcept C121608353 @default.
- W2327501875 hasConcept C126322002 @default.
- W2327501875 hasConcept C142724271 @default.
- W2327501875 hasConcept C143998085 @default.
- W2327501875 hasConcept C2776256026 @default.
- W2327501875 hasConcept C2780839634 @default.
- W2327501875 hasConcept C502942594 @default.
- W2327501875 hasConcept C530470458 @default.
- W2327501875 hasConcept C60644358 @default.
- W2327501875 hasConcept C71924100 @default.
- W2327501875 hasConcept C86803240 @default.
- W2327501875 hasConceptScore W2327501875C121608353 @default.
- W2327501875 hasConceptScore W2327501875C126322002 @default.
- W2327501875 hasConceptScore W2327501875C142724271 @default.
- W2327501875 hasConceptScore W2327501875C143998085 @default.
- W2327501875 hasConceptScore W2327501875C2776256026 @default.
- W2327501875 hasConceptScore W2327501875C2780839634 @default.
- W2327501875 hasConceptScore W2327501875C502942594 @default.
- W2327501875 hasConceptScore W2327501875C530470458 @default.
- W2327501875 hasConceptScore W2327501875C60644358 @default.
- W2327501875 hasConceptScore W2327501875C71924100 @default.
- W2327501875 hasConceptScore W2327501875C86803240 @default.
- W2327501875 hasLocation W23275018751 @default.
- W2327501875 hasOpenAccess W2327501875 @default.
- W2327501875 hasPrimaryLocation W23275018751 @default.
- W2327501875 hasRelatedWork W1948524999 @default.
- W2327501875 hasRelatedWork W1997914462 @default.
- W2327501875 hasRelatedWork W2051385644 @default.
- W2327501875 hasRelatedWork W2143871341 @default.
- W2327501875 hasRelatedWork W2147828078 @default.
- W2327501875 hasRelatedWork W2313033704 @default.
- W2327501875 hasRelatedWork W2407546188 @default.
- W2327501875 hasRelatedWork W2594241780 @default.
- W2327501875 hasRelatedWork W2885532732 @default.
- W2327501875 hasRelatedWork W2898391761 @default.
- W2327501875 hasRelatedWork W2903943172 @default.
- W2327501875 hasRelatedWork W2954249618 @default.
- W2327501875 hasRelatedWork W2995668563 @default.
- W2327501875 hasRelatedWork W3012719957 @default.
- W2327501875 hasRelatedWork W3013203289 @default.
- W2327501875 hasRelatedWork W3120257938 @default.
- W2327501875 hasRelatedWork W3140011679 @default.
- W2327501875 hasRelatedWork W3193337503 @default.
- W2327501875 hasRelatedWork W3194462954 @default.
- W2327501875 hasRelatedWork W3205912103 @default.
- W2327501875 isParatext "false" @default.
- W2327501875 isRetracted "false" @default.
- W2327501875 magId "2327501875" @default.
- W2327501875 workType "article" @default.