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- W2327525061 startingPage "211" @default.
- W2327525061 abstract "This investigation was concerned with the change of the bioavailability of a drug owing to the interaction of the drug-β-cyclodextrin complex with bile salts in rat intestinal lumen. The absorption of sulfamethizole (SMZ) from rat intestinal lumen after administration of SMZ-β-cyclodextrin complex was determined by a closed-loop method in the presence of absence of bile. The blood level of SMZ after administration of SMZ-β-cyclodextrin complex was significantly decreased in comparison with that after administration of SMZ alone in bile duct-ligated rats. On the other hand, the blood level of SMZ after SMZ-β-cyclodextrin administration in intact rats (bile duct non-ligated) or on the addition of sodium cholate was similar to the level in the case of SMZ alone. Thus, bile salts were found to act as a competing agent in the gastrointestinal tract." @default.
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- W2327525061 date "1989-01-01" @default.
- W2327525061 modified "2023-10-11" @default.
- W2327525061 title "Effect of the interaction of drug-.BETA.-cyclodextrin complex with bile salts on the drug absorption from rat small intestinal lumen." @default.
- W2327525061 doi "https://doi.org/10.1248/cpb.37.211" @default.
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