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- W2327532083 abstract "3063 Background: PHA-848125 (PHA) is a dual CDK/TRKA oral inhibitor showing significant single agent antitumor activity in several tumor models including pancreas (tumor growth inhibition range 65-74% in 3 pancreatic ca. xenograft models), prostate, lung, ovarian and glioma. In combination with gemcitabine (G), PHA exhibits synergistic effects in vitro and additive activity in the BX-PC3 human pancreatic ca. xenograft, at well tolerated doses. Methods: Phase I study to determine safety, pharmacokinetics (PK) and recommended dose for phase II (RP2D) of PHA/G combination in patients (pts) with advanced solid tumors. Cohorts of 3-6 pts received iv G on d1, 8, 15 and oral PHA once daily 7 days on/ 7 days off, in 4-week cycles (cy). At the fixed G dose of 1,000 mg/m2, PHA doses investigated were: 45 mg/m2 (3 pts), 60 mg/m2 (3 pts) and 80 mg/m2, the RP2D as a single agent (10 pts). Results: Sixteen pts (lung 5, mesothelioma 3, pancreas, prostate, colorectal 2 each, thymoma 1, thyroid 1) were treated for a total..." @default.
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- W2327532083 date "2010-05-20" @default.
- W2327532083 modified "2023-09-28" @default.
- W2327532083 title "Phase I study of the oral CDK-TRKA inhibitor PHA-848125 in combination with gemcitabine in advanced solid tumors." @default.
- W2327532083 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.3063" @default.
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