FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327564997> ?p ?o ?g. }

• W2327564997 endingPage "489" @default.
• W2327564997 startingPage "478" @default.
• W2327564997 abstract "Numerous evidences suggest that stress and stress-related hormones can modulate the activity of the brain reward pathway and thus may account for individual vulnerability towards the reinforcing effects of drugs of abuse. Transgenic (TG) mice expressing an antisense mRNA against the glucocorticoid receptor (GR), which partially blocks GR expression, were used to assess the role of GR dysfunction on cocaine (COC)-induced c-fos and Nerve-Growth Factor Inducible-B (NGFI-B, or Nur77) gene expression. These two genes belong to different families of transcription factors and have been shown to be modulated by various dopaminergic drugs. TG and wild-type (WT) mice were both acutely and repeatedly treated with COC (20 mg/kg, i.p.). In the chronic experiment, mice received a 5-day treatment of COC and were challenged 5 days later with COC or vehicle. Locomotor activity was assessed during the entire chronic experiment in the mouse home cages. Animals were sacrificed 1 h after the last injection and NGFI-B and c-fos mRNA levels in the prefrontal cortex, the nucleus accumbens and the striatum were measured by in situ hybridization. Acute COC administration led to significantly smaller c-fos increases in TG mice compared to WT, whereas repeated COC treatment potentiated c-fos induction both in TG and WT mice to equivalent levels. TG mice displayed higher basal NGFI-B expression in the nucleus accumbens and the level of NGFI-B mRNA was differently modulated by COC in TG mice compared to WT mice. In accordance with data on c-fos expression, behavioral data indicate a blunted locomotor effect on the first COC injection in TG mice, a phenomenon corrected by the repeated COC treatment. These results suggest that an alteration of the hypothalamus–pituitary–adrenal axis can modify COC-induced regulation of the transcription factors c-fos and NGFI-B, and that these changes parallel those seen at the behavioral level. It also demonstrates that the differences at the behavioral and molecular levels noted between TG and WT mice after acute COC injection disappear following repeated COC administration, suggesting that repeated COC has a greater impact in TG mice underexpressing GRs." @default.
• W2327564997 created "2016-06-24" @default.
• W2327564997 creator A5026499523 @default.
• W2327564997 creator A5038655862 @default.
• W2327564997 creator A5056303536 @default.
• W2327564997 creator A5062740038 @default.
• W2327564997 creator A5065146020 @default.
• W2327564997 date "2002-09-19" @default.
• W2327564997 modified "2023-10-12" @default.
• W2327564997 title "Effects of Cocaine on c-Fos and NGFI-B mRNA Expression in Transgenic Mice Underexpressing Glucocorticoid Receptors" @default.
• W2327564997 cites W1484575436 @default.
• W2327564997 cites W1576538880 @default.
• W2327564997 cites W1605427252 @default.
• W2327564997 cites W1967379165 @default.
• W2327564997 cites W1972314256 @default.
• W2327564997 cites W1973679532 @default.
• W2327564997 cites W1979433004 @default.
• W2327564997 cites W1981480708 @default.
• W2327564997 cites W1994331641 @default.
• W2327564997 cites W1998212115 @default.
• W2327564997 cites W2003014012 @default.
• W2327564997 cites W2009449932 @default.
• W2327564997 cites W2011275122 @default.
• W2327564997 cites W2013311561 @default.
• W2327564997 cites W2015599487 @default.
• W2327564997 cites W2019546178 @default.
• W2327564997 cites W2021223587 @default.
• W2327564997 cites W2023311163 @default.
• W2327564997 cites W2024618244 @default.
• W2327564997 cites W2025591257 @default.
• W2327564997 cites W2033158324 @default.
• W2327564997 cites W2049796382 @default.
• W2327564997 cites W2053639249 @default.
• W2327564997 cites W2053873291 @default.
• W2327564997 cites W2057234179 @default.
• W2327564997 cites W2057636933 @default.
• W2327564997 cites W2058757356 @default.
• W2327564997 cites W2061344417 @default.
• W2327564997 cites W2062489497 @default.
• W2327564997 cites W2063055166 @default.
• W2327564997 cites W2067210690 @default.
• W2327564997 cites W2068215811 @default.
• W2327564997 cites W2068289571 @default.
• W2327564997 cites W2068459961 @default.
• W2327564997 cites W2069472087 @default.
• W2327564997 cites W2070019933 @default.
• W2327564997 cites W2070022920 @default.
• W2327564997 cites W2070802389 @default.
• W2327564997 cites W2074073259 @default.
• W2327564997 cites W2074146823 @default.
• W2327564997 cites W2079048674 @default.
• W2327564997 cites W2079512326 @default.
• W2327564997 cites W2079679654 @default.
• W2327564997 cites W2089794813 @default.
• W2327564997 cites W2094331111 @default.
• W2327564997 cites W2094774961 @default.
• W2327564997 cites W2098017886 @default.
• W2327564997 cites W2111431369 @default.
• W2327564997 cites W2119096743 @default.
• W2327564997 cites W2122592499 @default.
• W2327564997 cites W2125508089 @default.
• W2327564997 cites W2127504265 @default.
• W2327564997 cites W2141001588 @default.
• W2327564997 cites W4231029313 @default.
• W2327564997 doi "https://doi.org/10.1038/sj.npp.1300067" @default.
• W2327564997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12629527" @default.
• W2327564997 hasPublicationYear "2002" @default.
• W2327564997 type Work @default.
• W2327564997 sameAs 2327564997 @default.
• W2327564997 citedByCount "27" @default.
• W2327564997 countsByYear W23275649972013 @default.
• W2327564997 countsByYear W23275649972018 @default.
• W2327564997 countsByYear W23275649972019 @default.
• W2327564997 countsByYear W23275649972022 @default.
• W2327564997 crossrefType "journal-article" @default.
• W2327564997 hasAuthorship W2327564997A5026499523 @default.
• W2327564997 hasAuthorship W2327564997A5038655862 @default.
• W2327564997 hasAuthorship W2327564997A5056303536 @default.
• W2327564997 hasAuthorship W2327564997A5062740038 @default.
• W2327564997 hasAuthorship W2327564997A5065146020 @default.
• W2327564997 hasBestOaLocation W23275649971 @default.
• W2327564997 hasConcept C104317684 @default.
• W2327564997 hasConcept C105580179 @default.
• W2327564997 hasConcept C126322002 @default.
• W2327564997 hasConcept C134018914 @default.
• W2327564997 hasConcept C137183658 @default.
• W2327564997 hasConcept C150194340 @default.
• W2327564997 hasConcept C170493617 @default.
• W2327564997 hasConcept C185592680 @default.
• W2327564997 hasConcept C2776552330 @default.
• W2327564997 hasConcept C2779555244 @default.
• W2327564997 hasConcept C2779715522 @default.
• W2327564997 hasConcept C2780062018 @default.
• W2327564997 hasConcept C2780323455 @default.
• W2327564997 hasConcept C2780841215 @default.
• W2327564997 hasConcept C513476851 @default.
• W2327564997 hasConcept C529278444 @default.
• W2327564997 hasConcept C55493867 @default.

• next