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• W2327570147 startingPage "82" @default.
• W2327570147 abstract "Purpose of review Long-term exposure to elevated concentrations of LDL cholesterol increases the risk of cardiovascular events. The main player in clearing LDL cholesterol is the LDL receptor (LDLR) trafficking pathway; however, our fundamental knowledge about the mechanisms regulating this pathway is still incomplete. Recent findings The LDLR pathway is very complex and involves multiple proteins. Endocytosis is regulated by two different adaptor proteins, that is, autosomal recessive hypercholesterolemia and Disabled-2. The proteolysis of the LDLR is regulated by inducible degrader of the LDLR and proprotein convertase subtilisin/kexin type 9. However, only a few proteins have been identified that provide insights into the endosomal sorting and recycling of the LDLR. Summary Since the discovery of LDLR, knowledge about its function has greatly expanded. As a result of its importance in maintaining homeostatic LDL levels, the LDLR pathway has emerged as a key therapeutic target to reduce circulating cholesterol. In order to be able to treat and diagnose individuals with hypercholesterolemia in the future, it is important to learn more about the LDLR trafficking pathway, as we still lack a full mechanistic understanding of how LDLR trafficking is controlled." @default.
• W2327570147 created "2016-06-24" @default.
• W2327570147 creator A5013598309 @default.
• W2327570147 creator A5031086317 @default.
• W2327570147 creator A5078422504 @default.
• W2327570147 date "2015-04-01" @default.
• W2327570147 modified "2023-09-27" @default.
• W2327570147 title "The life cycle of the low-density lipoprotein receptor" @default.
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• W2327570147 doi "https://doi.org/10.1097/mol.0000000000000157" @default.
• W2327570147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25692346" @default.
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