FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327576885> ?p ?o ?g. }

• W2327576885 endingPage "755" @default.
• W2327576885 startingPage "749" @default.
• W2327576885 abstract "In hypertriglyceridemic patients, hypertension occurs frequently and may be associated with hyperinsulinemia and elevated plasma levels of free fatty acids (FFA). Besides the lipid-lowering effects, fibrates have been shown to reduce blood pressure in hypertensive patients. The present study was undertaken to investigate the effects of bezafibrate on hemodynamics in relation to insulin, FFA, sympathetic activity, renal sodium absorption, cyclic-GMP (cGMP) and endothelin-1 in hypertriglyceridemic patients.Hypertriglyceridemic patients (17) were randomized to receive in a double-blind placebo-controlled study bezafibrate or placebo for 6 weeks. At the end of both treatment periods, blood pressure and heart rate were measured automatically. Plasma insulin, FFA, aldosterone, catecholamines, cGMP, endothelin-1 levels and 24 h urine catecholamines and sodium excretion were assessed.Bezafibrate therapy decreased serum triglycerides (-65%, P < 0.001) and hemodynamic parameters: heart rate decreased from 69 to 66/min (P = 0.009), systolic blood pressure from 137 to 132 mmHg (P = 0.01), diastolic blood pressure from 81 to 79 mmHg (P = 0.07) and mean blood pressure from 102 to 99 mmHg (P = 0.06). Bezafibrate therapy reduced FFA and insulin (-55 and -57% respectively, both P < 0.001), while sympathetic activity and renal sodium absorption were not affected. cGMP increased (+17%, P = 0.008), whereas endothelin-1 levels tended to decrease upon bezafibrate therapy (-10%, P = 0.077)Bezafibrate reduces heart rate, blood pressure, insulin and FFA in hypertriglyceridemic patients. The hemodynamic effects cannot be attributed to changes in sympathetic activity or renal sodium absorption. Instead, based on the increase in plasma cGMP levels, the bezafibrate-induced hemodynamic effects are most likely to be caused by bezafibrate-induced improvement of endothelial function." @default.
• W2327576885 created "2016-06-24" @default.
• W2327576885 creator A5007102136 @default.
• W2327576885 creator A5024883143 @default.
• W2327576885 creator A5035283138 @default.
• W2327576885 creator A5036206856 @default.
• W2327576885 creator A5046498472 @default.
• W2327576885 creator A5049173458 @default.
• W2327576885 creator A5082084230 @default.
• W2327576885 creator A5024409323 @default.
• W2327576885 date "2001-04-01" @default.
• W2327576885 modified "2023-10-16" @default.
• W2327576885 title "Bezafibrate reduces heart rate and blood pressure in patients with hypertriglyceridemia" @default.
• W2327576885 cites W1518913349 @default.
• W2327576885 cites W1905082515 @default.
• W2327576885 cites W1978666616 @default.
• W2327576885 cites W1978990205 @default.
• W2327576885 cites W1982811953 @default.
• W2327576885 cites W2012214559 @default.
• W2327576885 cites W2012379331 @default.
• W2327576885 cites W2019950065 @default.
• W2327576885 cites W2021201908 @default.
• W2327576885 cites W2027874598 @default.
• W2327576885 cites W2058455362 @default.
• W2327576885 cites W2060043648 @default.
• W2327576885 cites W2083419562 @default.
• W2327576885 cites W2086785365 @default.
• W2327576885 cites W2100585603 @default.
• W2327576885 cites W2103745497 @default.
• W2327576885 cites W2108834780 @default.
• W2327576885 cites W2110746447 @default.
• W2327576885 cites W2111038792 @default.
• W2327576885 cites W2120704015 @default.
• W2327576885 cites W2136841005 @default.
• W2327576885 cites W2145363298 @default.
• W2327576885 cites W2154263907 @default.
• W2327576885 cites W2160234571 @default.
• W2327576885 cites W2171533490 @default.
• W2327576885 cites W2313326603 @default.
• W2327576885 cites W2400712338 @default.
• W2327576885 cites W2414835254 @default.
• W2327576885 cites W4232807629 @default.
• W2327576885 cites W4238574661 @default.
• W2327576885 cites W4244278365 @default.
• W2327576885 cites W4251342213 @default.
• W2327576885 cites W4255038910 @default.
• W2327576885 cites W4376542714 @default.
• W2327576885 doi "https://doi.org/10.1097/00004872-200104000-00012" @default.
• W2327576885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11330878" @default.
• W2327576885 hasPublicationYear "2001" @default.
• W2327576885 type Work @default.
• W2327576885 sameAs 2327576885 @default.
• W2327576885 citedByCount "41" @default.
• W2327576885 countsByYear W23275768852012 @default.
• W2327576885 countsByYear W23275768852013 @default.
• W2327576885 countsByYear W23275768852014 @default.
• W2327576885 countsByYear W23275768852017 @default.
• W2327576885 countsByYear W23275768852018 @default.
• W2327576885 countsByYear W23275768852019 @default.
• W2327576885 countsByYear W23275768852020 @default.
• W2327576885 countsByYear W23275768852021 @default.
• W2327576885 countsByYear W23275768852022 @default.
• W2327576885 crossrefType "journal-article" @default.
• W2327576885 hasAuthorship W2327576885A5007102136 @default.
• W2327576885 hasAuthorship W2327576885A5024409323 @default.
• W2327576885 hasAuthorship W2327576885A5024883143 @default.
• W2327576885 hasAuthorship W2327576885A5035283138 @default.
• W2327576885 hasAuthorship W2327576885A5036206856 @default.
• W2327576885 hasAuthorship W2327576885A5046498472 @default.
• W2327576885 hasAuthorship W2327576885A5049173458 @default.
• W2327576885 hasAuthorship W2327576885A5082084230 @default.
• W2327576885 hasConcept C126322002 @default.
• W2327576885 hasConcept C134018914 @default.
• W2327576885 hasConcept C178853913 @default.
• W2327576885 hasConcept C2776362216 @default.
• W2327576885 hasConcept C2776919658 @default.
• W2327576885 hasConcept C2777391703 @default.
• W2327576885 hasConcept C2777953023 @default.
• W2327576885 hasConcept C2778163477 @default.
• W2327576885 hasConcept C2778913445 @default.
• W2327576885 hasConcept C2779306644 @default.
• W2327576885 hasConcept C2780988686 @default.
• W2327576885 hasConcept C71924100 @default.
• W2327576885 hasConcept C84393581 @default.
• W2327576885 hasConceptScore W2327576885C126322002 @default.
• W2327576885 hasConceptScore W2327576885C134018914 @default.
• W2327576885 hasConceptScore W2327576885C178853913 @default.
• W2327576885 hasConceptScore W2327576885C2776362216 @default.
• W2327576885 hasConceptScore W2327576885C2776919658 @default.
• W2327576885 hasConceptScore W2327576885C2777391703 @default.
• W2327576885 hasConceptScore W2327576885C2777953023 @default.
• W2327576885 hasConceptScore W2327576885C2778163477 @default.
• W2327576885 hasConceptScore W2327576885C2778913445 @default.
• W2327576885 hasConceptScore W2327576885C2779306644 @default.
• W2327576885 hasConceptScore W2327576885C2780988686 @default.
• W2327576885 hasConceptScore W2327576885C71924100 @default.
• W2327576885 hasConceptScore W2327576885C84393581 @default.
• W2327576885 hasIssue "4" @default.

• next