Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327579712> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- W2327579712 endingPage "2082" @default.
- W2327579712 startingPage "2076" @default.
- W2327579712 abstract "目的：探讨PI3K/Akt和JAK2/STAT3信号转导通路在二氧化硫（SO2）抗肢体缺血再灌注（I/R）致急性肺损伤中的作用。方法：应用双大腿根部绑扎止血带复制大鼠双后肢缺血再灌注肺损伤模型。在再灌注前20 min腹腔注射Na2SO3/Na HSO3;在再灌注前1 h静脉注射Stattic或LY294002。应用TUNEL、ELISA、Western blot等方法检测细胞凋亡、细胞因子表达及相关信号通路蛋白表达的情况。结果：与对照组相比,I/R组的MDA及MPO含量、肺系数、细胞凋亡指数、细胞因子表达以及p-STAT3、p-Akt蛋白的水平均显著增高;当应用Na2SO3/Na HSO3后,上述反映肺损伤的各项指标均下降。Western blot检测结果显示I/R后,肺组织中p-STAT3和p-Akt蛋白的水平均明显增加。而应用Na2SO3/Na HSO3后,p-Akt蛋白的水平继续增加,但p-STAT3蛋白的水平却减少（P〈0.05）。结论：JAK2/STAT3和PI3K/Akt信号通路都参与了SO2抗肢体缺血再灌注致急性肺损伤的作用。JAK2/STAT3通路的活化,能够使I/R损伤加重;相反,PI3K/Akt信号通路的活化,可以使I/R损伤减弱。此外,JAK2/STAT3和PI3K/Akt信号通路之间存在交互作用。" @default.
- W2327579712 created "2016-06-24" @default.
- W2327579712 creator A5008373160 @default.
- W2327579712 creator A5023691917 @default.
- W2327579712 creator A5047856806 @default.
- W2327579712 creator A5056177451 @default.
- W2327579712 creator A5059496644 @default.
- W2327579712 date "2015-11-15" @default.
- W2327579712 modified "2023-09-23" @default.
- W2327579712 title "PI3K/Akt和JAK2/STAT3信号转导通路在SO 2 抗大鼠肢体缺血再灌注致急性肺损伤中的作用" @default.
- W2327579712 doi "https://doi.org/10.3969/j.issn.1000-4718.2015.11.025" @default.
- W2327579712 hasPublicationYear "2015" @default.
- W2327579712 type Work @default.
- W2327579712 sameAs 2327579712 @default.
- W2327579712 citedByCount "0" @default.
- W2327579712 crossrefType "journal-article" @default.
- W2327579712 hasAuthorship W2327579712A5008373160 @default.
- W2327579712 hasAuthorship W2327579712A5023691917 @default.
- W2327579712 hasAuthorship W2327579712A5047856806 @default.
- W2327579712 hasAuthorship W2327579712A5056177451 @default.
- W2327579712 hasAuthorship W2327579712A5059496644 @default.
- W2327579712 hasConcept C11960822 @default.
- W2327579712 hasConcept C41008148 @default.
- W2327579712 hasConcept C62478195 @default.
- W2327579712 hasConcept C75217442 @default.
- W2327579712 hasConcept C86554907 @default.
- W2327579712 hasConcept C86803240 @default.
- W2327579712 hasConcept C95444343 @default.
- W2327579712 hasConceptScore W2327579712C11960822 @default.
- W2327579712 hasConceptScore W2327579712C41008148 @default.
- W2327579712 hasConceptScore W2327579712C62478195 @default.
- W2327579712 hasConceptScore W2327579712C75217442 @default.
- W2327579712 hasConceptScore W2327579712C86554907 @default.
- W2327579712 hasConceptScore W2327579712C86803240 @default.
- W2327579712 hasConceptScore W2327579712C95444343 @default.
- W2327579712 hasIssue "11" @default.
- W2327579712 hasLocation W23275797121 @default.
- W2327579712 hasOpenAccess W2327579712 @default.
- W2327579712 hasPrimaryLocation W23275797121 @default.
- W2327579712 hasVolume "31" @default.
- W2327579712 isParatext "false" @default.
- W2327579712 isRetracted "false" @default.
- W2327579712 magId "2327579712" @default.
- W2327579712 workType "article" @default.