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• W2327608849 startingPage "949" @default.
• W2327608849 abstract "Objectives Pancreatic interstitial cells are located among acini, ducts, nerves, and blood vessels. They are essential for pancreas development, physiology, and for oncogenic microenvironment. We identified cells with characteristic ultrastructural features of telocytes in pancreatic interstitium. Telocytes were initially described as interstitial Cajal-like cells, but it gradually became clear that they were a distinct novel cell type not directly related to canonical interstitial Cajal cells. Methods Serial ultrathin sections of human pancreatic tissue were studied by transmission electron microscopy. Computer analysis software was used to obtain 2-dimensional compositions from serial micrographs and to perform morphometry. Results Pancreatic telocytes appear as small-body cells with prolongations called telopodes. The ultrastructural features of telopodes are the following: (a) number: 1 to 3; (b) length: tens of micrometers; (c) moniliform aspect: with podoms (thicker portions) and podomers (thin segments, with a mean width of 60 nm, undetectable by light microscopy); (d) dichotomous branching forming a network; (e) establish homocellular and heterocellular junctions; (f) release of microvesicles/multivesicular bodies. Telopodes pass close to blood vessels, nerves, and pancreatic acinar cells and ducts. Conclusions Telocytes are present as distinct interstitial cells in the exocrine pancreatic stroma. They act as important players in intercellular signaling via stromal synapses and shed vesicle transfer." @default.
• W2327608849 created "2016-06-24" @default.
• W2327608849 creator A5015896605 @default.
• W2327608849 creator A5023534770 @default.
• W2327608849 date "2012-08-01" @default.
• W2327608849 modified "2023-10-18" @default.
• W2327608849 title "Telocytes in the Interstitium of Human Exocrine Pancreas" @default.
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• W2327608849 doi "https://doi.org/10.1097/mpa.0b013e31823fbded" @default.
• W2327608849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22318257" @default.
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