FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327654344> ?p ?o ?g. }

• W2327654344 abstract "Descriptions of the South American arrow poisons known as curares were reported by explorers in the 16th century, and their site of action in producing neuromuscular block was determined by Claude Bernard in the mid‐19th century. Tubocurarine, the most important curare alkaloid, played a large part in experiments to determine the role of acetylcholine in neuromuscular transmission, but it was not until after 1943 that neuromuscular blocking drugs became established as muscle relaxants for use during surgical anaesthesia. Tubocurarine causes a number of unwanted effects, and there have been many attempts to replace it. The available drugs fall into two main categories: the depolarising blocking drugs and the nondepolarising blocking drugs. The former act by complex mixed actions and are now obsolete with the exception of suxamethonium, the rapid onset and brief duration of action of which remain useful for intubation at the start of surgical anaesthesia. The nondepolarising blocking drugs are reversible acetylcholine receptor antagonists. The main ones are the atracurium group, which possess a built‐in self‐destruct mechanism that makes them especially useful in kidney or liver failure, and the vecuronium group, which are especially free from unwanted side effects. Of this latter group, the compound rocuronium is of especial interest because its rapid onset of action allows it to be used for intubation, and there is promise that its duration of action may be rapidly terminated by a novel antagonist, a particular cyclodextrin, that chelates the drug, thereby removing it from the acetylcholine receptors. British Journal of Pharmacology (2006) 147 , S277–S286. doi: 10.1038/sj.bjp.0706404" @default.
• W2327654344 created "2016-06-24" @default.
• W2327654344 creator A5012169787 @default.
• W2327654344 date "2006-01-01" @default.
• W2327654344 modified "2023-10-01" @default.
• W2327654344 title "Neuromuscular block" @default.
• W2327654344 cites W106782019 @default.
• W2327654344 cites W1950897149 @default.
• W2327654344 cites W1966976559 @default.
• W2327654344 cites W1969741365 @default.
• W2327654344 cites W1971074263 @default.
• W2327654344 cites W1974691120 @default.
• W2327654344 cites W1976791266 @default.
• W2327654344 cites W1981709257 @default.
• W2327654344 cites W1984145146 @default.
• W2327654344 cites W2014849169 @default.
• W2327654344 cites W2028263839 @default.
• W2327654344 cites W2031209399 @default.
• W2327654344 cites W2031974929 @default.
• W2327654344 cites W2038272248 @default.
• W2327654344 cites W2046075911 @default.
• W2327654344 cites W2050538030 @default.
• W2327654344 cites W2052402296 @default.
• W2327654344 cites W2068188579 @default.
• W2327654344 cites W2070091924 @default.
• W2327654344 cites W2076326993 @default.
• W2327654344 cites W2088431116 @default.
• W2327654344 cites W2089724001 @default.
• W2327654344 cites W2094212442 @default.
• W2327654344 cites W2105451199 @default.
• W2327654344 cites W2120999808 @default.
• W2327654344 cites W2225936741 @default.
• W2327654344 cites W2281372485 @default.
• W2327654344 cites W4241693769 @default.
• W2327654344 cites W4242304549 @default.
• W2327654344 cites W4318471184 @default.
• W2327654344 cites W4318600682 @default.
• W2327654344 cites W2015817837 @default.
• W2327654344 doi "https://doi.org/10.1038/sj.bjp.0706404" @default.
• W2327654344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16402115" @default.
• W2327654344 hasPublicationYear "2006" @default.
• W2327654344 type Work @default.
• W2327654344 sameAs 2327654344 @default.
• W2327654344 citedByCount "136" @default.
• W2327654344 countsByYear W23276543442012 @default.
• W2327654344 countsByYear W23276543442013 @default.
• W2327654344 countsByYear W23276543442014 @default.
• W2327654344 countsByYear W23276543442015 @default.
• W2327654344 countsByYear W23276543442016 @default.
• W2327654344 countsByYear W23276543442017 @default.
• W2327654344 countsByYear W23276543442018 @default.
• W2327654344 countsByYear W23276543442019 @default.
• W2327654344 countsByYear W23276543442020 @default.
• W2327654344 countsByYear W23276543442021 @default.
• W2327654344 countsByYear W23276543442022 @default.
• W2327654344 countsByYear W23276543442023 @default.
• W2327654344 crossrefType "journal-article" @default.
• W2327654344 hasAuthorship W2327654344A5012169787 @default.
• W2327654344 hasBestOaLocation W23276543442 @default.
• W2327654344 hasConcept C126322002 @default.
• W2327654344 hasConcept C15744967 @default.
• W2327654344 hasConcept C169760540 @default.
• W2327654344 hasConcept C170493617 @default.
• W2327654344 hasConcept C2775910092 @default.
• W2327654344 hasConcept C2775939251 @default.
• W2327654344 hasConcept C2776885963 @default.
• W2327654344 hasConcept C2776988050 @default.
• W2327654344 hasConcept C2777240379 @default.
• W2327654344 hasConcept C2778716859 @default.
• W2327654344 hasConcept C2910841738 @default.
• W2327654344 hasConcept C3020341438 @default.
• W2327654344 hasConcept C42219234 @default.
• W2327654344 hasConcept C71924100 @default.
• W2327654344 hasConcept C98274493 @default.
• W2327654344 hasConceptScore W2327654344C126322002 @default.
• W2327654344 hasConceptScore W2327654344C15744967 @default.
• W2327654344 hasConceptScore W2327654344C169760540 @default.
• W2327654344 hasConceptScore W2327654344C170493617 @default.
• W2327654344 hasConceptScore W2327654344C2775910092 @default.
• W2327654344 hasConceptScore W2327654344C2775939251 @default.
• W2327654344 hasConceptScore W2327654344C2776885963 @default.
• W2327654344 hasConceptScore W2327654344C2776988050 @default.
• W2327654344 hasConceptScore W2327654344C2777240379 @default.
• W2327654344 hasConceptScore W2327654344C2778716859 @default.
• W2327654344 hasConceptScore W2327654344C2910841738 @default.
• W2327654344 hasConceptScore W2327654344C3020341438 @default.
• W2327654344 hasConceptScore W2327654344C42219234 @default.
• W2327654344 hasConceptScore W2327654344C71924100 @default.
• W2327654344 hasConceptScore W2327654344C98274493 @default.
• W2327654344 hasIssue "S1" @default.
• W2327654344 hasLocation W23276543441 @default.
• W2327654344 hasLocation W23276543442 @default.
• W2327654344 hasLocation W23276543443 @default.
• W2327654344 hasLocation W23276543444 @default.
• W2327654344 hasOpenAccess W2327654344 @default.
• W2327654344 hasPrimaryLocation W23276543441 @default.
• W2327654344 hasRelatedWork W185446235 @default.
• W2327654344 hasRelatedWork W1966562800 @default.
• W2327654344 hasRelatedWork W1998367886 @default.
• W2327654344 hasRelatedWork W2098240752 @default.

• next