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- W2327720309 endingPage "189" @default.
- W2327720309 startingPage "189" @default.
- W2327720309 abstract "This review was based on a literature search of PubMed and Scielo databases using the keywords quercetin, rutin, isoquercitrin, isoquercitin (IQ), quercetin-3-glucoside, bioavailability, flavonols and favonoids, and cancer and combinations of all the words. We collected relevant scientific publications from 1990 to 2015 about the absorption, bioavailability, chemoprevention activity, and treatment effects as well as the underlying anticancer mechanisms of isoquercitin. Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom. The subclass of flavonols receives special attention owing to their health benefits. The main components of this class are quercetin, rutin, and IQ, which is a flavonoid and although mostly found as a glycoside, is an aglycone (lacks a glycoside side chain). This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form. IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic. The protective effects of IQ in cancer may be due to actions on lipid peroxidation. In addition, the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway, mixed-lineage protein kinase 3, mitogen-activated protein kinase, apoptotic pathways, as well proinflammatory protein signaling. This review contributed to clarifying the mechanisms of absorption, metabolism, and actions of IQ and isoquercitrin in cancer." @default.
- W2327720309 created "2016-06-24" @default.
- W2327720309 creator A5005028935 @default.
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- W2327720309 creator A5065656444 @default.
- W2327720309 creator A5081230130 @default.
- W2327720309 creator A5086969575 @default.
- W2327720309 date "2016-01-01" @default.
- W2327720309 modified "2023-09-23" @default.
- W2327720309 title "Review of anticancer mechanisms of isoquercitin" @default.
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