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- W2327720452 abstract "P172 While HTLV-1 and HTLV-2 have both been shown to transform human lymphocytes, the mechanism of transformation remains unclear. In both cases, transformation is dependent upon the viral encoded Tax protein. We have recently reported that the tumor suppressor p53 is inactivated in HTLV-1-transformed cells through a novel pathway involving phosphorylation of specific amino acids in the p53 transcription activation domain. If p53 inactivation plays an important role in viral transformation, a similar inactivation of p53 would be expected in HTLV-2-transformed cells. We now demonstrate by western blot analysis that p53 is stabilized in three IL-2-dependent or -independent human cell lines transformed by HTLV-2. We further show by transient transfection and examining the response to gamma-irradiation, that p53 was inactivated in the HTLV-2 transformed cells. Using wild-type and Tax2 mutants, we are now determining the role of Tax2 protein in p53 inactivation. Comparison of the action of HTLV-I and HTLV-2 Tax protein on p53 function will provide important insight into the mechanism of viral transformation." @default.
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- W2327720452 date "1999-04-01" @default.
- W2327720452 modified "2023-10-18" @default.
- W2327720452 title "INACTIVATION OF THE P53 TUMOR SUPPRESSOR IN HTLV-2 IMMORTALIZED/TRANSFORMED CELLS" @default.
- W2327720452 doi "https://doi.org/10.1097/00042560-199904010-00275" @default.
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