Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327722012> ?p ?o ?g. }
- W2327722012 endingPage "809" @default.
- W2327722012 startingPage "794" @default.
- W2327722012 abstract "Although the use of corticosteroids and immunosuppressive agents such as cyclophosphamide and mycophenolate has led to reduced mortality in systemic lupus erythematosus (SLE), there is a need for development of new biologic agents to improve outcomes further. The pathogenesis of SLE involves many components of the immune system, notably B cells, T cells, cytokines and innate immunity, which are potential targets for the new biologic therapies. In this study, the rationale for the development of new therapies in SLE and the progress that has been made in each direction of therapy are described. Most progress has been made with agents directed against B cells, especially rituximab and belimumab and the latter has been the subject of two successful randomised clinical trials (RCTs). Anti-T-cell and anti-cytokine therapies are further back in the development process, but promising advances can be anticipated over the next decade." @default.
- W2327722012 created "2016-06-24" @default.
- W2327722012 creator A5006623910 @default.
- W2327722012 creator A5024237017 @default.
- W2327722012 creator A5059682164 @default.
- W2327722012 date "2015-12-01" @default.
- W2327722012 modified "2023-10-16" @default.
- W2327722012 title "New therapeutic avenues in SLE" @default.
- W2327722012 cites W1501881726 @default.
- W2327722012 cites W1679569810 @default.
- W2327722012 cites W1688265474 @default.
- W2327722012 cites W1787953040 @default.
- W2327722012 cites W1963552316 @default.
- W2327722012 cites W1966335538 @default.
- W2327722012 cites W1966613111 @default.
- W2327722012 cites W1975307585 @default.
- W2327722012 cites W1982924102 @default.
- W2327722012 cites W1989273660 @default.
- W2327722012 cites W1992913167 @default.
- W2327722012 cites W1994649501 @default.
- W2327722012 cites W2004553615 @default.
- W2327722012 cites W2005278031 @default.
- W2327722012 cites W2008924465 @default.
- W2327722012 cites W2009154052 @default.
- W2327722012 cites W2010854505 @default.
- W2327722012 cites W2013787067 @default.
- W2327722012 cites W2014912378 @default.
- W2327722012 cites W2016899230 @default.
- W2327722012 cites W2017709470 @default.
- W2327722012 cites W2024228574 @default.
- W2327722012 cites W2025412364 @default.
- W2327722012 cites W2027632198 @default.
- W2327722012 cites W2028825739 @default.
- W2327722012 cites W2029957805 @default.
- W2327722012 cites W2039229549 @default.
- W2327722012 cites W2043298079 @default.
- W2327722012 cites W2046330020 @default.
- W2327722012 cites W2049628940 @default.
- W2327722012 cites W2060253834 @default.
- W2327722012 cites W2066486914 @default.
- W2327722012 cites W2070391335 @default.
- W2327722012 cites W2070811352 @default.
- W2327722012 cites W2071444250 @default.
- W2327722012 cites W2074674463 @default.
- W2327722012 cites W2075715794 @default.
- W2327722012 cites W2080549619 @default.
- W2327722012 cites W2087008638 @default.
- W2327722012 cites W2090627427 @default.
- W2327722012 cites W2095265014 @default.
- W2327722012 cites W2095671546 @default.
- W2327722012 cites W2098540204 @default.
- W2327722012 cites W2098881967 @default.
- W2327722012 cites W2103258308 @default.
- W2327722012 cites W2106273198 @default.
- W2327722012 cites W2108529019 @default.
- W2327722012 cites W2118994799 @default.
- W2327722012 cites W2119296184 @default.
- W2327722012 cites W2119929190 @default.
- W2327722012 cites W2121469878 @default.
- W2327722012 cites W2121690331 @default.
- W2327722012 cites W2123255564 @default.
- W2327722012 cites W2127396740 @default.
- W2327722012 cites W2131457901 @default.
- W2327722012 cites W2133228420 @default.
- W2327722012 cites W2136149088 @default.
- W2327722012 cites W2142659101 @default.
- W2327722012 cites W2145966444 @default.
- W2327722012 cites W2146853551 @default.
- W2327722012 cites W2148838644 @default.
- W2327722012 cites W2154831555 @default.
- W2327722012 cites W2161537704 @default.
- W2327722012 cites W2164318693 @default.
- W2327722012 cites W2165779517 @default.
- W2327722012 cites W2168888135 @default.
- W2327722012 cites W2171641622 @default.
- W2327722012 cites W2318971911 @default.
- W2327722012 cites W2411432169 @default.
- W2327722012 cites W4292083220 @default.
- W2327722012 doi "https://doi.org/10.1016/j.berh.2016.02.007" @default.
- W2327722012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27107514" @default.
- W2327722012 hasPublicationYear "2015" @default.
- W2327722012 type Work @default.
- W2327722012 sameAs 2327722012 @default.
- W2327722012 citedByCount "11" @default.
- W2327722012 countsByYear W23277220122016 @default.
- W2327722012 countsByYear W23277220122017 @default.
- W2327722012 countsByYear W23277220122018 @default.
- W2327722012 countsByYear W23277220122019 @default.
- W2327722012 countsByYear W23277220122021 @default.
- W2327722012 countsByYear W23277220122022 @default.
- W2327722012 crossrefType "journal-article" @default.
- W2327722012 hasAuthorship W2327722012A5006623910 @default.
- W2327722012 hasAuthorship W2327722012A5024237017 @default.
- W2327722012 hasAuthorship W2327722012A5059682164 @default.
- W2327722012 hasConcept C126322002 @default.
- W2327722012 hasConcept C159654299 @default.
- W2327722012 hasConcept C170286685 @default.
- W2327722012 hasConcept C203014093 @default.