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• W2327751462 abstract "Enhancer of rudimentary homolog (ERH) is a small, highly conserved protein among eukaryotes. Since its discovery nearly 20 years ago, its molecular function has remained enigmatic. It has been implicated to play a role in transcriptional regulation and in cell cycle. We recently showed that ERH binds to the Sm complex and is required for the mRNA splicing of the mitotic motor protein CENP-E. Fur- thermore, cancer cells driven by mutations in the KRAS oncogene are particularly sensitive to RNAi-mediated suppression of ERH function, and ERH expression is inversely correlated with survival in colorectal cancer pa- tients whose tumors harbor KRAS mutation. These recent fi ndings indicate that ERH plays an important role in cell cycle through its mRNA splicing activity and is critically required for genomic stability and cancer cell survival." @default.
• W2327751462 created "2016-06-24" @default.
• W2327751462 creator A5007711481 @default.
• W2327751462 creator A5044758224 @default.
• W2327751462 date "2013-01-01" @default.
• W2327751462 modified "2023-10-18" @default.
• W2327751462 title "The enigmatic ERH protein: its role in cell cycle, RNA splicing and cancer INI-REVIEW M" @default.
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• W2327751462 hasPublicationYear "2013" @default.
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