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- W2327756869 abstract "Preliminary retrospective chromosomal analysis was performed using fluorescence in situ hybridization (FISH) with alphoid DNA probes for chromosomes 1, 3, 6, 8, 12, 17, and X. Twenty-four epithelial ovarian tumors were examined in this pilot study, including 8 borderline (LMP) serous tumors, 9 serous carcinoma, and 7 mucinous carcinoma. Hybridization signals were counted to demonstrate the frequency of aneusomy, trace chromosomal progression, and identify the predominance of chromosome copy number abnormalities that are specific to a particular histotype. The preliminary results revealed almost an equal number of mean aneusomies in serous (58.13 ± 13%) and mucinous (64.33 ± 10%) carcinoma, both of which were slightly higher than borderline serous tumors (50.57 ± 17%). Hyposomies 3 and X were significantly higher in mucinous than in serous ovarian carcinomas, and lowest in borderline serous tumors (P <0.05 and P <0.01). Signal losses were a more frequent abnormality in all three histologic subtypes. Mucinous carcinomas showed a loss of chromosomes 8 (45.00 ± 28%) and 3 (43.14 ± 16%), in addition to a loss of chromosome X (56.29 ± 12%). Serous carcinomas showed a gain of chromosome 1 (39.44 ± 32%), followed by losses of chromosomes 6 (37.00 ± 20%), 17 (36.44 ± 19%), and 8 (36.89 ± 19%). In borderline serous tumors, the most frequent findings were losses of chromosomes 6 (38.00 ± 17%), 12 (36.88 ± 17%), and 3 (36.13 ± 21%). However, further research is necessary to substantiate these preliminary results and elucidate their clinical significance. A brief review of the literature pertaining to interphase cytogenetics in ovarian epithelial tumors is discussed also." @default.
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- W2327756869 date "2002-06-01" @default.
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- W2327756869 title "Detection of Numerical Chromosomal Abnormalities in Epithelial Ovarian Neoplasms by Fluorescence In Situ Hybridization (Fish) and a Review of the Current Literature" @default.
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- W2327756869 doi "https://doi.org/10.1097/00129039-200206000-00016" @default.
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