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- W2327775061 abstract "Heart failure is the leading cause of hospitalization of elderly patients. There is a correlation between heart failure and myocardial fibrosis, which is defined as the deposition of excess extracellular matrix proteins such as collagen. A key regulator of collagen homeostasis is lysyl oxidase (LOX), an enzyme that is responsible for crosslinking of deposited collagen fibers. When collagen is cross-linked, it is stable and less prone to degradation. Our objective wasto improve age-related myocardial fibrosis by disrupting collagen cross-linking through inhibiting LOX in a model of age-related fibrosis." @default.
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- W2327775061 date "2013-10-01" @default.
- W2327775061 modified "2023-09-25" @default.
- W2327775061 title "Age Related Fibrosis Is Improved by Reducing Collagen Cross-Linking With Lysyl Oxidase Inhibition" @default.
- W2327775061 doi "https://doi.org/10.1016/j.cjca.2013.07.400" @default.
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