Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327789489> ?p ?o ?g. }
- W2327789489 endingPage "1045" @default.
- W2327789489 startingPage "1039" @default.
- W2327789489 abstract "Two types of anthraquinone conjugates were synthesized as non-nucleosidic oligonucleotide components. These include an anthraquinone derivative conjugated with 2,2-bis(hydroxymethyl)propionic acid and an anthraquinone–polyamine derivative conjugated with 2,2-bis(hydroxymethyl)propionic acid. The conjugates were successfully incorporated into the “linking-region” of the α–β chimeric oligonucleotides via phosphoramidite method as non-nucleosidic backbone units. The resultant novel α–β chimeric oligonucleotides possessed two diastereomers that were generated by the introduction of the anthraquinone conjugate with a stereogenic carbon atom. The isomers were successfully separated by a reversed-phase HPLC. UV-melting experiments revealed that both stereoisomers formed a substantially stable alternate-strand triple helix, irrespective of the stereochemistry of the incorporated non-nucleosidic backbone unit. However, the enhancing effect on thermal stability depended on the length of the alkyl linker connecting anthraquinone moiety and the propionic acid moiety. The sequence discrimination ability of the chimeric oligonucleotides toward mismatch target duplex was also examined. The Tm values of the triplexes containing the mismatch target were substantially lower than the Tm values of those containing the full-match target. The thermodynamic parameters (ΔH°, ΔS°, and ΔG°) required for the dissociation of the triplexes into the third strand and target duplex were also measured." @default.
- W2327789489 created "2016-06-24" @default.
- W2327789489 creator A5002901402 @default.
- W2327789489 creator A5048157283 @default.
- W2327789489 creator A5090030930 @default.
- W2327789489 date "2011-05-25" @default.
- W2327789489 modified "2023-09-26" @default.
- W2327789489 title "Stabilizing Effect of Propionic Acid Derivative of Anthraquinone–Polyamine Conjugate Incorporated into α–β Chimeric Oligonucleotides on the Alternate-Stranded Triple Helix" @default.
- W2327789489 cites W1027635430 @default.
- W2327789489 cites W194599053 @default.
- W2327789489 cites W1970570745 @default.
- W2327789489 cites W1971015423 @default.
- W2327789489 cites W1975909498 @default.
- W2327789489 cites W1981954020 @default.
- W2327789489 cites W1988324364 @default.
- W2327789489 cites W1989147047 @default.
- W2327789489 cites W1990979304 @default.
- W2327789489 cites W2010759469 @default.
- W2327789489 cites W2016291329 @default.
- W2327789489 cites W2019220858 @default.
- W2327789489 cites W2019790624 @default.
- W2327789489 cites W2020737102 @default.
- W2327789489 cites W2022438991 @default.
- W2327789489 cites W2023036582 @default.
- W2327789489 cites W2024241029 @default.
- W2327789489 cites W2032069911 @default.
- W2327789489 cites W2035485234 @default.
- W2327789489 cites W2037244550 @default.
- W2327789489 cites W2043156595 @default.
- W2327789489 cites W2046890781 @default.
- W2327789489 cites W2053447212 @default.
- W2327789489 cites W2053986728 @default.
- W2327789489 cites W2063362501 @default.
- W2327789489 cites W2067115399 @default.
- W2327789489 cites W2072722462 @default.
- W2327789489 cites W2081620468 @default.
- W2327789489 cites W2098226519 @default.
- W2327789489 cites W2106858736 @default.
- W2327789489 cites W2109498610 @default.
- W2327789489 cites W2111543678 @default.
- W2327789489 cites W2154574968 @default.
- W2327789489 cites W2157864651 @default.
- W2327789489 cites W2286703179 @default.
- W2327789489 cites W2326493716 @default.
- W2327789489 cites W4237284287 @default.
- W2327789489 doi "https://doi.org/10.1021/bc100446w" @default.
- W2327789489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21528922" @default.
- W2327789489 hasPublicationYear "2011" @default.
- W2327789489 type Work @default.
- W2327789489 sameAs 2327789489 @default.
- W2327789489 citedByCount "2" @default.
- W2327789489 countsByYear W23277894892013 @default.
- W2327789489 countsByYear W23277894892015 @default.
- W2327789489 crossrefType "journal-article" @default.
- W2327789489 hasAuthorship W2327789489A5002901402 @default.
- W2327789489 hasAuthorship W2327789489A5048157283 @default.
- W2327789489 hasAuthorship W2327789489A5090030930 @default.
- W2327789489 hasConcept C10919887 @default.
- W2327789489 hasConcept C111919701 @default.
- W2327789489 hasConcept C112613896 @default.
- W2327789489 hasConcept C129312508 @default.
- W2327789489 hasConcept C134306372 @default.
- W2327789489 hasConcept C178790620 @default.
- W2327789489 hasConcept C185592680 @default.
- W2327789489 hasConcept C197336794 @default.
- W2327789489 hasConcept C21951064 @default.
- W2327789489 hasConcept C2776568683 @default.
- W2327789489 hasConcept C2778913731 @default.
- W2327789489 hasConcept C2780557392 @default.
- W2327789489 hasConcept C33923547 @default.
- W2327789489 hasConcept C41008148 @default.
- W2327789489 hasConcept C521977710 @default.
- W2327789489 hasConcept C552990157 @default.
- W2327789489 hasConcept C55493867 @default.
- W2327789489 hasConcept C71240020 @default.
- W2327789489 hasConceptScore W2327789489C10919887 @default.
- W2327789489 hasConceptScore W2327789489C111919701 @default.
- W2327789489 hasConceptScore W2327789489C112613896 @default.
- W2327789489 hasConceptScore W2327789489C129312508 @default.
- W2327789489 hasConceptScore W2327789489C134306372 @default.
- W2327789489 hasConceptScore W2327789489C178790620 @default.
- W2327789489 hasConceptScore W2327789489C185592680 @default.
- W2327789489 hasConceptScore W2327789489C197336794 @default.
- W2327789489 hasConceptScore W2327789489C21951064 @default.
- W2327789489 hasConceptScore W2327789489C2776568683 @default.
- W2327789489 hasConceptScore W2327789489C2778913731 @default.
- W2327789489 hasConceptScore W2327789489C2780557392 @default.
- W2327789489 hasConceptScore W2327789489C33923547 @default.
- W2327789489 hasConceptScore W2327789489C41008148 @default.
- W2327789489 hasConceptScore W2327789489C521977710 @default.
- W2327789489 hasConceptScore W2327789489C552990157 @default.
- W2327789489 hasConceptScore W2327789489C55493867 @default.
- W2327789489 hasConceptScore W2327789489C71240020 @default.
- W2327789489 hasIssue "6" @default.
- W2327789489 hasLocation W23277894891 @default.
- W2327789489 hasLocation W23277894892 @default.
- W2327789489 hasOpenAccess W2327789489 @default.
- W2327789489 hasPrimaryLocation W23277894891 @default.