FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327817424> ?p ?o ?g. }

• W2327817424 endingPage "117" @default.
• W2327817424 startingPage "117" @default.
• W2327817424 abstract "To the Editors: Isolation of measles virus has typically been from respiratory, blood or urine specimens, but identification from the skin has not been documented. We describe the first known case of measles vaccine-associated disease in a DiGeorge patient on tumor necrosis factor inhibitor therapy in which genotype A Edmonston vaccine strain virus was identified from skin scrapings of the patient’s rash. A 12-year-old boy was admitted to our hospital with a 2-day history of tactile fevers, sore throat, rash and conjunctivitis. Ten days earlier, he had inadvertently received the measles, mumps, rubella and varicella vaccine during a well-child visit. His past medical history was remarkable for DiGeorge syndrome, repaired Tetralogy of Fallot and juvenile idiopathic arthritis diagnosed at 15 months of age, which had been controlled for the past 5 years with weekly injections of the tumor necrosis factor inhibitor etanercept. With the exception of live virus vaccines, he was otherwise up-to-date with his immunizations. He had recently undergone immune evaluation with a lymphocyte count of 1100 × 109 cells/L, of which the lymphocyte subsets were normal. The lymphocyte mitogen and antigen studies included low-normal responses to Candida and phytohemagglutinin and normal responses to tetanus, concanavalin A and pokeweed mitogen. Antibody titers to prior inactivated vaccines were normal. After he developed the tactile fevers, his mother held further doses of etanercept, and he was directly admitted to the hospital. On admission, he was afebrile and appeared well. His examination was remarkable for mild conjunctivitis, palatal petechiae with posterior pharyngeal erythema and a blanching morbilliform rash that was present behind the ears, on the face, neck, back, chest and limbs. Mild post auricular cervical lymphadenopathy was present. There were no Koplik spots or vesicular lesions. Due to the possibility of an atypical varicella rash in a patient on a biologic immunomodulatory medication, intravenous acyclovir was initiated and the Minnesota Department of Health was notified. Scrapings of the rash were sent to evaluate for varicella zoster virus, and a urine sample and a buccal swab were collected for evaluation of measles virus. Nucleic acids were isolated from the urine and skin samples using the Qiagen Viral RNA Mini Kit (Qiagen, Germantown, MD). Detection of measles virus was attained with a real-time TaqMan reverse transcription polymerase chain reaction targeting the nucleoprotein (N) gene.1 Genotyping was determined following World Health Organization-recommended sequencing, which were aligned with CDC-designated reference sequences using MEGA5 software.2 Both urine and skin samples were positive in triplicate for measles virus by reverse transcription polymerase chain reaction with 100% matched identity to each other and phylogenetically clustered as genotype A with Edmonston reference strain (AF266288). The buccal swab was inconclusive based on extraction control failure. Although excretion of measles virus in his urine enabled detection and sequencing of the virus as a measles vaccine strain, the diagnosis of vaccine-associated disease was determined from the skin scrapings.3 Measles virus is present in the skin rash during illness;4 however, to our knowledge, this is the first reported measles vaccine case in which the vaccine strain was detected and genotyped from the skin rash. Pui-Ying Iroh Tam, MD Benjamin R. Hanisch, MD Division of Pediatric Infectious Diseases, University of Minnesota Amplatz Children’s Hospital Minneapolis, MN Kate Klammer, BS Aaron S. DeVries, MD, MPH Minnesota Department of Health St. Paul, MN" @default.
• W2327817424 created "2016-06-24" @default.
• W2327817424 creator A5044234401 @default.
• W2327817424 creator A5048544581 @default.
• W2327817424 creator A5067877202 @default.
• W2327817424 creator A5075611963 @default.
• W2327817424 date "2014-01-01" @default.
• W2327817424 modified "2023-09-23" @default.
• W2327817424 title "Measles Vaccine Strain From the Skin Rash of a DiGeorge Patient Receiving Tumor Necrosis Factor Inhibitor" @default.
• W2327817424 cites W2073215113 @default.
• W2327817424 cites W2103463654 @default.
• W2327817424 cites W2107932177 @default.
• W2327817424 cites W2132632499 @default.
• W2327817424 doi "https://doi.org/10.1097/inf.0000000000000073" @default.
• W2327817424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4385583" @default.
• W2327817424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24346604" @default.
• W2327817424 hasPublicationYear "2014" @default.
• W2327817424 type Work @default.
• W2327817424 sameAs 2327817424 @default.
• W2327817424 citedByCount "5" @default.
• W2327817424 countsByYear W23278174242014 @default.
• W2327817424 countsByYear W23278174242017 @default.
• W2327817424 countsByYear W23278174242020 @default.
• W2327817424 countsByYear W23278174242022 @default.
• W2327817424 countsByYear W23278174242023 @default.
• W2327817424 crossrefType "journal-article" @default.
• W2327817424 hasAuthorship W2327817424A5044234401 @default.
• W2327817424 hasAuthorship W2327817424A5048544581 @default.
• W2327817424 hasAuthorship W2327817424A5067877202 @default.
• W2327817424 hasAuthorship W2327817424A5075611963 @default.
• W2327817424 hasBestOaLocation W23278174241 @default.
• W2327817424 hasConcept C118552586 @default.
• W2327817424 hasConcept C126322002 @default.
• W2327817424 hasConcept C142724271 @default.
• W2327817424 hasConcept C159047783 @default.
• W2327817424 hasConcept C16005928 @default.
• W2327817424 hasConcept C17991360 @default.
• W2327817424 hasConcept C203014093 @default.
• W2327817424 hasConcept C22070199 @default.
• W2327817424 hasConcept C2776438120 @default.
• W2327817424 hasConcept C2778022156 @default.
• W2327817424 hasConcept C2778570526 @default.
• W2327817424 hasConcept C2779634000 @default.
• W2327817424 hasConcept C2779688345 @default.
• W2327817424 hasConcept C2780657872 @default.
• W2327817424 hasConcept C2780801004 @default.
• W2327817424 hasConcept C503630168 @default.
• W2327817424 hasConcept C71924100 @default.
• W2327817424 hasConcept C8891405 @default.
• W2327817424 hasConceptScore W2327817424C118552586 @default.
• W2327817424 hasConceptScore W2327817424C126322002 @default.
• W2327817424 hasConceptScore W2327817424C142724271 @default.
• W2327817424 hasConceptScore W2327817424C159047783 @default.
• W2327817424 hasConceptScore W2327817424C16005928 @default.
• W2327817424 hasConceptScore W2327817424C17991360 @default.
• W2327817424 hasConceptScore W2327817424C203014093 @default.
• W2327817424 hasConceptScore W2327817424C22070199 @default.
• W2327817424 hasConceptScore W2327817424C2776438120 @default.
• W2327817424 hasConceptScore W2327817424C2778022156 @default.
• W2327817424 hasConceptScore W2327817424C2778570526 @default.
• W2327817424 hasConceptScore W2327817424C2779634000 @default.
• W2327817424 hasConceptScore W2327817424C2779688345 @default.
• W2327817424 hasConceptScore W2327817424C2780657872 @default.
• W2327817424 hasConceptScore W2327817424C2780801004 @default.
• W2327817424 hasConceptScore W2327817424C503630168 @default.
• W2327817424 hasConceptScore W2327817424C71924100 @default.
• W2327817424 hasConceptScore W2327817424C8891405 @default.
• W2327817424 hasIssue "1" @default.
• W2327817424 hasLocation W23278174241 @default.
• W2327817424 hasLocation W23278174242 @default.
• W2327817424 hasLocation W23278174243 @default.
• W2327817424 hasLocation W23278174244 @default.
• W2327817424 hasOpenAccess W2327817424 @default.
• W2327817424 hasPrimaryLocation W23278174241 @default.
• W2327817424 hasRelatedWork W1042478810 @default.
• W2327817424 hasRelatedWork W1503171333 @default.
• W2327817424 hasRelatedWork W1963701145 @default.
• W2327817424 hasRelatedWork W1974011926 @default.
• W2327817424 hasRelatedWork W2127962592 @default.
• W2327817424 hasRelatedWork W2356734437 @default.
• W2327817424 hasRelatedWork W2902493007 @default.
• W2327817424 hasRelatedWork W3081847396 @default.
• W2327817424 hasRelatedWork W3160699413 @default.
• W2327817424 hasRelatedWork W4229053820 @default.
• W2327817424 hasVolume "33" @default.
• W2327817424 isParatext "false" @default.
• W2327817424 isRetracted "false" @default.
• W2327817424 magId "2327817424" @default.
• W2327817424 workType "article" @default.