Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327828572> ?p ?o ?g. }
- W2327828572 abstract "Under normal physiological conditions pancreatic β-cells secrete insulin to maintain fasting blood glucose levels in the range 3.5-5.5mmol/L. In hyperinsulinaemic hypoglycaemia (HH) this precise regulation of insulin secretion is perturbed so that insulin continues to be secreted in the presence of hypoglycaemia. HH may be due to genetic causes (congenital) or secondary to certain risk factors. The molecular mechanisms leading to HH involve defects in the key genes regulating insulin secretion from the β-cells. At this moment in time genetic abnormalities in 9 genes (ABCC8, KCNJ11, GCK, SCHAD, GLUD1, SLC16A1, HNF1A, HNF4A and UCP2) have been described that lead to the congenital forms of HH. Perinatal stress, intrauterine growth retardation, maternal diabetes mellitus and a large number of developmental syndromes are also associated with HH in the neonatal period. In older children and adult’s insulinoma, Noninsulinoma pancreatogenous hypoglycaemia syndrome and post bariatric surgery are recognised causes of HH. This review article will focus mainly on describing the molecular mechanisms that lead to unregulated insulin secretion." @default.
- W2327828572 created "2016-06-24" @default.
- W2327828572 creator A5000322092 @default.
- W2327828572 creator A5028293344 @default.
- W2327828572 creator A5038674267 @default.
- W2327828572 date "2016-03-31" @default.
- W2327828572 modified "2023-10-15" @default.
- W2327828572 title "Hyperinsulinemic Hypoglycemia – The Molecular Mechanisms" @default.
- W2327828572 cites W124504601 @default.
- W2327828572 cites W1494442706 @default.
- W2327828572 cites W1504187995 @default.
- W2327828572 cites W1526357026 @default.
- W2327828572 cites W1572740209 @default.
- W2327828572 cites W1603990889 @default.
- W2327828572 cites W1958062876 @default.
- W2327828572 cites W1963637633 @default.
- W2327828572 cites W1965209959 @default.
- W2327828572 cites W1965368873 @default.
- W2327828572 cites W1972987087 @default.
- W2327828572 cites W1975863794 @default.
- W2327828572 cites W1976967454 @default.
- W2327828572 cites W1977796924 @default.
- W2327828572 cites W1985770721 @default.
- W2327828572 cites W1986381180 @default.
- W2327828572 cites W1986421416 @default.
- W2327828572 cites W1990137877 @default.
- W2327828572 cites W1990845205 @default.
- W2327828572 cites W1992803871 @default.
- W2327828572 cites W1995938592 @default.
- W2327828572 cites W1996092773 @default.
- W2327828572 cites W2000507048 @default.
- W2327828572 cites W2001827575 @default.
- W2327828572 cites W2004410736 @default.
- W2327828572 cites W2005150634 @default.
- W2327828572 cites W2005854851 @default.
- W2327828572 cites W2008677894 @default.
- W2327828572 cites W2010735159 @default.
- W2327828572 cites W2011413530 @default.
- W2327828572 cites W2015087409 @default.
- W2327828572 cites W2015452748 @default.
- W2327828572 cites W2017283119 @default.
- W2327828572 cites W2019851584 @default.
- W2327828572 cites W2023758510 @default.
- W2327828572 cites W2026198488 @default.
- W2327828572 cites W2028247996 @default.
- W2327828572 cites W2031158920 @default.
- W2327828572 cites W2033349405 @default.
- W2327828572 cites W2034234838 @default.
- W2327828572 cites W2036372088 @default.
- W2327828572 cites W2038353863 @default.
- W2327828572 cites W2046120487 @default.
- W2327828572 cites W2047169350 @default.
- W2327828572 cites W2055250293 @default.
- W2327828572 cites W2056226832 @default.
- W2327828572 cites W2058012195 @default.
- W2327828572 cites W2059328843 @default.
- W2327828572 cites W2059502948 @default.
- W2327828572 cites W2059757087 @default.
- W2327828572 cites W2061743337 @default.
- W2327828572 cites W2061787346 @default.
- W2327828572 cites W2063247572 @default.
- W2327828572 cites W2064953660 @default.
- W2327828572 cites W2067382803 @default.
- W2327828572 cites W2069271978 @default.
- W2327828572 cites W2069799200 @default.
- W2327828572 cites W2072834756 @default.
- W2327828572 cites W2074306054 @default.
- W2327828572 cites W2074605366 @default.
- W2327828572 cites W2078668386 @default.
- W2327828572 cites W2081616441 @default.
- W2327828572 cites W2083584165 @default.
- W2327828572 cites W2085346343 @default.
- W2327828572 cites W2086345475 @default.
- W2327828572 cites W2087589871 @default.
- W2327828572 cites W2088221687 @default.
- W2327828572 cites W2090375415 @default.
- W2327828572 cites W2090714092 @default.
- W2327828572 cites W2092435069 @default.
- W2327828572 cites W2093185798 @default.
- W2327828572 cites W2093632126 @default.
- W2327828572 cites W2097248117 @default.
- W2327828572 cites W2097689482 @default.
- W2327828572 cites W2098227908 @default.
- W2327828572 cites W2099365712 @default.
- W2327828572 cites W2103806994 @default.
- W2327828572 cites W2106509892 @default.
- W2327828572 cites W2106890006 @default.
- W2327828572 cites W2111189973 @default.
- W2327828572 cites W2111949403 @default.
- W2327828572 cites W2113755495 @default.
- W2327828572 cites W2115515282 @default.
- W2327828572 cites W2115981867 @default.
- W2327828572 cites W2116145810 @default.
- W2327828572 cites W2117134832 @default.
- W2327828572 cites W2118382451 @default.
- W2327828572 cites W2118417356 @default.
- W2327828572 cites W2118877053 @default.
- W2327828572 cites W2119164190 @default.
- W2327828572 cites W2122719865 @default.
- W2327828572 cites W2123030369 @default.