Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327836063> ?p ?o ?g. }
- W2327836063 endingPage "366" @default.
- W2327836063 startingPage "360" @default.
- W2327836063 abstract "Previous reports indicate that rabbits are not an appropriate species for testing glycoprotein (GP) IIb/IIIa antagonists because tested compounds caused only a weak inhibitory action on aggregation of rabbit platelets. SR 121566 is a novel low-molecular-weight antiplatelet agent with high affinity and specificity for the GP IIb/IIIa complex. In this study, SR 121566 exhibited a potent dose-dependent inhibition of adenosine diphosphate (ADP)-induced aggregation of rabbit platelets in vitro [median inhibitory concentration (IC50), 0.8 +/- 0.04 microM], whereas the GP IIb/IIIa antagonists SC 52012A and GR 144053F were devoid of antiplatelet activity. After oral administration of SR 121787, the prodrug of SR 121566, rabbit platelet aggregation ex vivo was inhibited in a dose-dependent manner [median effective dose (ED50) for ADP- arachidonic acid (AA)- and collagen-induced aggregation 2 h after gavage, 2.3 +/- 0.3, 6.1 +/- 0.9, and 2.5 +/- 0.4 mg/kg], a 58% inhibition of ADP-induced platelet aggregation being still observed 6 h after single oral treatment with 20 mg/kg. In an arteriovenous-shunt model, oral administration of SR 121787 resulted in a dose-dependent inhibition of thrombus growth (ED50, 10.4 +/- 0.8 mg/kg). Clopidogrel revealed a maximal inhibitory efficacy of 40% at 20 mg/kg p.o., and aspirin, at 100 mg/kg p.o., was without effect in this model. SR 121787 at oral doses < or = 10 mg/kg, did not cause an increase in blood loss after incision of the rabbit ear. In conclusion, SR 121787 is the first GP IIb/IIIa antagonist with oral antiplatelet and antithrombotic activity in rabbits." @default.
- W2327836063 created "2016-06-24" @default.
- W2327836063 creator A5005417745 @default.
- W2327836063 creator A5008391830 @default.
- W2327836063 creator A5024759773 @default.
- W2327836063 creator A5057526959 @default.
- W2327836063 date "1997-09-01" @default.
- W2327836063 modified "2023-10-15" @default.
- W2327836063 title "Antiplatelet and Antithrombotic Efficacy of SR 121787, a Nonpeptide Orally Active GP IIb/IIIa Antagonist, in Rabbits: Comparison with Clopidogrel and Aspirin" @default.
- W2327836063 cites W1518372943 @default.
- W2327836063 cites W1602674819 @default.
- W2327836063 cites W1972520725 @default.
- W2327836063 cites W1999919117 @default.
- W2327836063 cites W2001546214 @default.
- W2327836063 cites W2005419086 @default.
- W2327836063 cites W2012214760 @default.
- W2327836063 cites W2012330153 @default.
- W2327836063 cites W2026624464 @default.
- W2327836063 cites W2030219408 @default.
- W2327836063 cites W2033551885 @default.
- W2327836063 cites W2039496408 @default.
- W2327836063 cites W2052000438 @default.
- W2327836063 cites W2055435744 @default.
- W2327836063 cites W2085013636 @default.
- W2327836063 cites W2108471572 @default.
- W2327836063 cites W2149326232 @default.
- W2327836063 cites W2367313565 @default.
- W2327836063 cites W2417001584 @default.
- W2327836063 cites W2418497326 @default.
- W2327836063 cites W4324114048 @default.
- W2327836063 doi "https://doi.org/10.1097/00005344-199709000-00014" @default.
- W2327836063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9300321" @default.
- W2327836063 hasPublicationYear "1997" @default.
- W2327836063 type Work @default.
- W2327836063 sameAs 2327836063 @default.
- W2327836063 citedByCount "17" @default.
- W2327836063 crossrefType "journal-article" @default.
- W2327836063 hasAuthorship W2327836063A5005417745 @default.
- W2327836063 hasAuthorship W2327836063A5008391830 @default.
- W2327836063 hasAuthorship W2327836063A5024759773 @default.
- W2327836063 hasAuthorship W2327836063A5057526959 @default.
- W2327836063 hasConcept C126322002 @default.
- W2327836063 hasConcept C150903083 @default.
- W2327836063 hasConcept C170493617 @default.
- W2327836063 hasConcept C185592680 @default.
- W2327836063 hasConcept C202751555 @default.
- W2327836063 hasConcept C207001950 @default.
- W2327836063 hasConcept C26291073 @default.
- W2327836063 hasConcept C2776885963 @default.
- W2327836063 hasConcept C2777015399 @default.
- W2327836063 hasConcept C2777056448 @default.
- W2327836063 hasConcept C2777399203 @default.
- W2327836063 hasConcept C2777628954 @default.
- W2327836063 hasConcept C2777752497 @default.
- W2327836063 hasConcept C2777849778 @default.
- W2327836063 hasConcept C2909112448 @default.
- W2327836063 hasConcept C2993802102 @default.
- W2327836063 hasConcept C42533223 @default.
- W2327836063 hasConcept C55493867 @default.
- W2327836063 hasConcept C71924100 @default.
- W2327836063 hasConcept C86803240 @default.
- W2327836063 hasConcept C89560881 @default.
- W2327836063 hasConcept C98274493 @default.
- W2327836063 hasConceptScore W2327836063C126322002 @default.
- W2327836063 hasConceptScore W2327836063C150903083 @default.
- W2327836063 hasConceptScore W2327836063C170493617 @default.
- W2327836063 hasConceptScore W2327836063C185592680 @default.
- W2327836063 hasConceptScore W2327836063C202751555 @default.
- W2327836063 hasConceptScore W2327836063C207001950 @default.
- W2327836063 hasConceptScore W2327836063C26291073 @default.
- W2327836063 hasConceptScore W2327836063C2776885963 @default.
- W2327836063 hasConceptScore W2327836063C2777015399 @default.
- W2327836063 hasConceptScore W2327836063C2777056448 @default.
- W2327836063 hasConceptScore W2327836063C2777399203 @default.
- W2327836063 hasConceptScore W2327836063C2777628954 @default.
- W2327836063 hasConceptScore W2327836063C2777752497 @default.
- W2327836063 hasConceptScore W2327836063C2777849778 @default.
- W2327836063 hasConceptScore W2327836063C2909112448 @default.
- W2327836063 hasConceptScore W2327836063C2993802102 @default.
- W2327836063 hasConceptScore W2327836063C42533223 @default.
- W2327836063 hasConceptScore W2327836063C55493867 @default.
- W2327836063 hasConceptScore W2327836063C71924100 @default.
- W2327836063 hasConceptScore W2327836063C86803240 @default.
- W2327836063 hasConceptScore W2327836063C89560881 @default.
- W2327836063 hasConceptScore W2327836063C98274493 @default.
- W2327836063 hasIssue "3" @default.
- W2327836063 hasLocation W23278360631 @default.
- W2327836063 hasLocation W23278360632 @default.
- W2327836063 hasOpenAccess W2327836063 @default.
- W2327836063 hasPrimaryLocation W23278360631 @default.
- W2327836063 hasRelatedWork W188894582 @default.
- W2327836063 hasRelatedWork W1977409210 @default.
- W2327836063 hasRelatedWork W2021692569 @default.
- W2327836063 hasRelatedWork W2050767985 @default.
- W2327836063 hasRelatedWork W2098421595 @default.
- W2327836063 hasRelatedWork W2099734408 @default.
- W2327836063 hasRelatedWork W2263774463 @default.
- W2327836063 hasRelatedWork W2379512234 @default.