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- W2327843961 startingPage "S580" @default.
- W2327843961 abstract "Urinary concentrations of trimethoprim (TMP) and its metabolites were measured in eight healthy subjects after oral administration of 160 mg of TMP in two tablets of Septra® (trimethoprim-sulfamethoxazole). Improved procedures for extraction of polar metabolites and for enzymic cleavage of conjugated products were applied. The 1-oxide and conjugates of demethylated metabolites were found in substantially higher concentrations than those previously reported. A new metabolite, the 3-oxide of TMP, was identified, and urinary levels of this product were also measured." @default.
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- W2327843961 date "1973-11-01" @default.
- W2327843961 modified "2023-10-10" @default.
- W2327843961 title "Metabolism of Trimethoprim in Man and Measurement of a New Metabolite: A New Fluorescence Assay" @default.
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- W2327843961 doi "https://doi.org/10.1093/infdis/128.supplement_3.s580" @default.
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