Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327852006> ?p ?o ?g. }
- W2327852006 endingPage "15750" @default.
- W2327852006 startingPage "15743" @default.
- W2327852006 abstract "Label-free biosensor technologies have the potential to revolutionize environmental monitoring, medical diagnostics, and food safety evaluation processes due to their unique combinations of high-sensitivity signal transducers and high-specificity recognition elements. This enables their ability to perform real-time detection of deleterious compounds at extremely low concentrations. However, to further improve the biosensors’ performance in complex environments, such as wastewater, blood, and urine, it is necessary to minimize nonspecific binding, which in turn will increase their specificity, and decrease the rate of false positives. In the present work, we illustrate the potential of combining emerging high-sensitivity optical signal transducers, such as whispering gallery mode (WGM) microcavities, with covalently bound poly(ethylene glycol) (PEG) coatings of varying thickness, as an effective treatment for the prevention of nonspecific protein adsorption onto the biosensor surface. We monitor the sensitivity of the coated biosensor, and investigate the effect of PEG chain length on minimizing nonspecific adsorption via protein adsorption studies. Experimental results confirm not only that PEG-functionalization reduces nonspecific protein adsorption to the surface of the sensor by as much as a factor of 4 compared to an initialized control surface, but also that chain length significantly impacts the nonfouling character of the microcavity surface. Surprisingly, it is the short chain PEG surfaces that experience the best improvement in specificity, unlike many other systems where longer PEG chains are preferred. The combination of WGM microcavities with PEG coatings tuned specifically to the device will significantly improve the overall performance of biosensor platforms, and enable their wider application in complex, real-world monitoring scenarios." @default.
- W2327852006 created "2016-06-24" @default.
- W2327852006 creator A5002655737 @default.
- W2327852006 creator A5017437898 @default.
- W2327852006 creator A5040017247 @default.
- W2327852006 creator A5069848723 @default.
- W2327852006 date "2012-10-23" @default.
- W2327852006 modified "2023-10-05" @default.
- W2327852006 title "Tailoring the Protein Adsorption Properties of Whispering Gallery Mode Optical Biosensors" @default.
- W2327852006 cites W1495905026 @default.
- W2327852006 cites W1554342785 @default.
- W2327852006 cites W1969375854 @default.
- W2327852006 cites W1971375143 @default.
- W2327852006 cites W1981118658 @default.
- W2327852006 cites W1996045920 @default.
- W2327852006 cites W1997023256 @default.
- W2327852006 cites W2000763360 @default.
- W2327852006 cites W2003461347 @default.
- W2327852006 cites W2013983495 @default.
- W2327852006 cites W2022212201 @default.
- W2327852006 cites W2024004515 @default.
- W2327852006 cites W2026246847 @default.
- W2327852006 cites W2031376643 @default.
- W2327852006 cites W2035875342 @default.
- W2327852006 cites W2040170408 @default.
- W2327852006 cites W2040845319 @default.
- W2327852006 cites W2045184826 @default.
- W2327852006 cites W2045260522 @default.
- W2327852006 cites W2055926917 @default.
- W2327852006 cites W2056127911 @default.
- W2327852006 cites W2059702407 @default.
- W2327852006 cites W2060802064 @default.
- W2327852006 cites W2062823301 @default.
- W2327852006 cites W2062832237 @default.
- W2327852006 cites W2063637713 @default.
- W2327852006 cites W2074469051 @default.
- W2327852006 cites W2076335042 @default.
- W2327852006 cites W2076927456 @default.
- W2327852006 cites W2078739630 @default.
- W2327852006 cites W2085738178 @default.
- W2327852006 cites W2087172103 @default.
- W2327852006 cites W2103739638 @default.
- W2327852006 cites W2106962111 @default.
- W2327852006 cites W2110662580 @default.
- W2327852006 cites W2114578038 @default.
- W2327852006 cites W2114689990 @default.
- W2327852006 cites W2118651170 @default.
- W2327852006 cites W2121374199 @default.
- W2327852006 cites W2143308799 @default.
- W2327852006 cites W2145378119 @default.
- W2327852006 cites W2150153786 @default.
- W2327852006 cites W2151480728 @default.
- W2327852006 cites W2159330001 @default.
- W2327852006 cites W2164697448 @default.
- W2327852006 cites W2165033806 @default.
- W2327852006 cites W2316422128 @default.
- W2327852006 cites W2333038355 @default.
- W2327852006 cites W2487187460 @default.
- W2327852006 doi "https://doi.org/10.1021/la302041d" @default.
- W2327852006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23061463" @default.
- W2327852006 hasPublicationYear "2012" @default.
- W2327852006 type Work @default.
- W2327852006 sameAs 2327852006 @default.
- W2327852006 citedByCount "50" @default.
- W2327852006 countsByYear W23278520062013 @default.
- W2327852006 countsByYear W23278520062014 @default.
- W2327852006 countsByYear W23278520062015 @default.
- W2327852006 countsByYear W23278520062016 @default.
- W2327852006 countsByYear W23278520062017 @default.
- W2327852006 countsByYear W23278520062018 @default.
- W2327852006 countsByYear W23278520062019 @default.
- W2327852006 countsByYear W23278520062020 @default.
- W2327852006 countsByYear W23278520062021 @default.
- W2327852006 countsByYear W23278520062022 @default.
- W2327852006 countsByYear W23278520062023 @default.
- W2327852006 crossrefType "journal-article" @default.
- W2327852006 hasAuthorship W2327852006A5002655737 @default.
- W2327852006 hasAuthorship W2327852006A5017437898 @default.
- W2327852006 hasAuthorship W2327852006A5040017247 @default.
- W2327852006 hasAuthorship W2327852006A5069848723 @default.
- W2327852006 hasConcept C10138342 @default.
- W2327852006 hasConcept C115537861 @default.
- W2327852006 hasConcept C121332964 @default.
- W2327852006 hasConcept C147789679 @default.
- W2327852006 hasConcept C150394285 @default.
- W2327852006 hasConcept C160756335 @default.
- W2327852006 hasConcept C162324750 @default.
- W2327852006 hasConcept C171250308 @default.
- W2327852006 hasConcept C178790620 @default.
- W2327852006 hasConcept C185592680 @default.
- W2327852006 hasConcept C192562407 @default.
- W2327852006 hasConcept C21951064 @default.
- W2327852006 hasConcept C2777516009 @default.
- W2327852006 hasConcept C49040817 @default.
- W2327852006 hasConcept C54400483 @default.
- W2327852006 hasConcept C56318395 @default.
- W2327852006 hasConcept C62520636 @default.
- W2327852006 hasConcept C77255779 @default.