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- W2327854013 abstract "Thermal injuries induce intense pain. Opioids are extensively used as analgesics to control burn pain. However, systemic administration of opioids induces multiple adverse effects that are primarily CNS mediated. Alternately, topical application of low dose of opioids directly at the site of injury could attenuate pain while avoiding CNS-mediated side effects. Pluronic lecithin organogels (PLO) have been extensively used as vehicles to deliver topical drugs. In this study, we for the first time assessed the analgesic efficacy of three opioid-PLO formulations (fentanyl, methadone & morphine) in a rat full-thickness thermal injury (FTTI) pain model that we have previously developed. A single 0.1 ml topical application of either morphine (5 mg/ml), fentanyl (10 μg/ml) or methadone gel (5 mg/ml) was administered to the plantar surface of the injured hindpaw on days 4 and 7 following thermal injury. The anti-hyperalgesic effects were then measured (5, 15, 30, 60 and 120 min post-drug application) using the Hargreaves’ thermal test. All three opioids produced statistically significant increases in paw withdrawal latency (PWL), taken as a measure of anti-hyperalgesic, in comparison to saline-treated group (P < 0.05), at both 4 and 7 days post injury, with fentanyl showing greatest efficacy. At day 4, but not day 7, there was a statistically significant anti-hyperalgesic effect of the PLO vehicle alone, at 15 min post drug treatment. Effects on PWL for the contralateral paw (uninjured) were detected for some of the treatments, indicating a potential for non-local effects. Additional experiments are being conducted to resolve this question, as well to explore the potential for tolerance to develop after repeated/prolonged opioid application. In conclusion, a low dose topical application of opioids can reduce thermal hyperalgesia in a rat hindpaw FTTI model, supporting the development of topical formulations of these drugs for burn pain treatment in the clinic." @default.
- W2327854013 created "2016-06-24" @default.
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- W2327854013 date "2016-04-01" @default.
- W2327854013 modified "2023-09-23" @default.
- W2327854013 title "(358) Antinociceptive effects of pluronic lecithin organo (PLO) opioid gels in rats with thermal injury" @default.
- W2327854013 doi "https://doi.org/10.1016/j.jpain.2016.01.265" @default.
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