Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327861424> ?p ?o ?g. }
- W2327861424 endingPage "247" @default.
- W2327861424 startingPage "241" @default.
- W2327861424 abstract "Although recognized for their sedative properties, benzodiazepines are also known to impair sustained and selective attention. Flumazenil at low doses may act to antagonize benzodiazepine-induced effects. This study examined whether low doses of flumazenil would improve event-related brain potential (ERP) indicators of selective attention and induce feelings of activation and anxiety in healthy men. Data from 11 men (24-30 years) who received intravenous flumazenil (0.2 mg, plus 0.3 mg 30 minutes later) and placebo were analyzed according to a double-blind crossover design. ERPs were recorded while subjects performed an auditory selective attention task. Mismatch negativity (MMN), processing negativity (PN), and the P3 component were extracted from the ERP as markers of preattentive mismatch processing, selective attention, and stimulus processing within working memory, respectively. Counting accuracy and performance on a letter cancellation test were used as behavioral indicators of attention. Mood was assessed by an adjective checklist and the State-Trait Anxiety Inventory. Flumazenil significantly increased PN over frontocortical areas, indicating improved selective attention (p < 0.05). Increases in the P3 amplitude and MMN after drug treatment remained nonsignificant. Subjects felt more activated and extraverted after flumazenil treatment than after placebo (p < 0.05). Anxiety was not increased. The findings of this study confirm the concept that flumazenil administered at a low dose in humans exerts effects opposite to those of benzodiazepines." @default.
- W2327861424 created "2016-06-24" @default.
- W2327861424 creator A5007263253 @default.
- W2327861424 creator A5011035658 @default.
- W2327861424 creator A5035706383 @default.
- W2327861424 creator A5036040037 @default.
- W2327861424 date "1998-06-01" @default.
- W2327861424 modified "2023-09-23" @default.
- W2327861424 title "Enhanced Selective Attention After Low-Dose Administration of the Benzodiazepine Antagonist Flumazenil" @default.
- W2327861424 cites W1963895644 @default.
- W2327861424 cites W1968514574 @default.
- W2327861424 cites W1969867129 @default.
- W2327861424 cites W1975055947 @default.
- W2327861424 cites W1977127683 @default.
- W2327861424 cites W1993068191 @default.
- W2327861424 cites W1994966798 @default.
- W2327861424 cites W2004011823 @default.
- W2327861424 cites W2009043033 @default.
- W2327861424 cites W2021279036 @default.
- W2327861424 cites W2032312348 @default.
- W2327861424 cites W2038166177 @default.
- W2327861424 cites W2051042764 @default.
- W2327861424 cites W2054207550 @default.
- W2327861424 cites W2054493102 @default.
- W2327861424 cites W2055685624 @default.
- W2327861424 cites W2067478103 @default.
- W2327861424 cites W2070572114 @default.
- W2327861424 cites W2071592165 @default.
- W2327861424 cites W2085247523 @default.
- W2327861424 cites W2086486304 @default.
- W2327861424 cites W2089266265 @default.
- W2327861424 cites W2095181002 @default.
- W2327861424 cites W2135961695 @default.
- W2327861424 doi "https://doi.org/10.1097/00004714-199806000-00010" @default.
- W2327861424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9617984" @default.
- W2327861424 hasPublicationYear "1998" @default.
- W2327861424 type Work @default.
- W2327861424 sameAs 2327861424 @default.
- W2327861424 citedByCount "31" @default.
- W2327861424 countsByYear W23278614242012 @default.
- W2327861424 countsByYear W23278614242014 @default.
- W2327861424 countsByYear W23278614242015 @default.
- W2327861424 countsByYear W23278614242016 @default.
- W2327861424 countsByYear W23278614242017 @default.
- W2327861424 countsByYear W23278614242019 @default.
- W2327861424 countsByYear W23278614242021 @default.
- W2327861424 crossrefType "journal-article" @default.
- W2327861424 hasAuthorship W2327861424A5007263253 @default.
- W2327861424 hasAuthorship W2327861424A5011035658 @default.
- W2327861424 hasAuthorship W2327861424A5035706383 @default.
- W2327861424 hasAuthorship W2327861424A5036040037 @default.
- W2327861424 hasConcept C118552586 @default.
- W2327861424 hasConcept C126322002 @default.
- W2327861424 hasConcept C142724271 @default.
- W2327861424 hasConcept C15744967 @default.
- W2327861424 hasConcept C169760540 @default.
- W2327861424 hasConcept C170493617 @default.
- W2327861424 hasConcept C192769605 @default.
- W2327861424 hasConcept C204787440 @default.
- W2327861424 hasConcept C21715850 @default.
- W2327861424 hasConcept C27081682 @default.
- W2327861424 hasConcept C2778173252 @default.
- W2327861424 hasConcept C2778409475 @default.
- W2327861424 hasConcept C2780733359 @default.
- W2327861424 hasConcept C42219234 @default.
- W2327861424 hasConcept C522805319 @default.
- W2327861424 hasConcept C548259974 @default.
- W2327861424 hasConcept C558461103 @default.
- W2327861424 hasConcept C71924100 @default.
- W2327861424 hasConcept C87813604 @default.
- W2327861424 hasConceptScore W2327861424C118552586 @default.
- W2327861424 hasConceptScore W2327861424C126322002 @default.
- W2327861424 hasConceptScore W2327861424C142724271 @default.
- W2327861424 hasConceptScore W2327861424C15744967 @default.
- W2327861424 hasConceptScore W2327861424C169760540 @default.
- W2327861424 hasConceptScore W2327861424C170493617 @default.
- W2327861424 hasConceptScore W2327861424C192769605 @default.
- W2327861424 hasConceptScore W2327861424C204787440 @default.
- W2327861424 hasConceptScore W2327861424C21715850 @default.
- W2327861424 hasConceptScore W2327861424C27081682 @default.
- W2327861424 hasConceptScore W2327861424C2778173252 @default.
- W2327861424 hasConceptScore W2327861424C2778409475 @default.
- W2327861424 hasConceptScore W2327861424C2780733359 @default.
- W2327861424 hasConceptScore W2327861424C42219234 @default.
- W2327861424 hasConceptScore W2327861424C522805319 @default.
- W2327861424 hasConceptScore W2327861424C548259974 @default.
- W2327861424 hasConceptScore W2327861424C558461103 @default.
- W2327861424 hasConceptScore W2327861424C71924100 @default.
- W2327861424 hasConceptScore W2327861424C87813604 @default.
- W2327861424 hasIssue "3" @default.
- W2327861424 hasLocation W23278614241 @default.
- W2327861424 hasLocation W23278614242 @default.
- W2327861424 hasOpenAccess W2327861424 @default.
- W2327861424 hasPrimaryLocation W23278614241 @default.
- W2327861424 hasRelatedWork W1995255503 @default.
- W2327861424 hasRelatedWork W2027442223 @default.
- W2327861424 hasRelatedWork W2067986278 @default.
- W2327861424 hasRelatedWork W2069887444 @default.