FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327870009> ?p ?o ?g. }

• W2327870009 endingPage "F67" @default.
• W2327870009 startingPage "F60" @default.
• W2327870009 abstract "20-Hydroxyeicosatetraenoic acid (20-HETE), a potent vasoconstrictor and mediator of the myogenic response, is a major arachidonic acid metabolite in the microvasculature of the rat kidney formed primarily by the cytochrome P-450 (CYP) 4A isoforms, CYP4A1, CYP4A2, and CYP4A3. We examined CYP4A isoform expression and 20-HETE synthesis in microdissected interlobar, arcuate, and interlobular arteries; mRNA for all CYP4A isoforms was identified by RT-PCR. Western blot analysis indicated that the levels of CYP4A2/4A3-immunoreactive protein increased with decreased arterial diameter, whereas those of CYP4A1-immunoreactive protein remained unchanged. 20-HETE synthesis was the highest in the interlobular arteries (17 +/- 1.62 nmol. mg(-1). h(-1)) and, like CYP4A2/4A3-immunoreactive protein, decreased with increasing vessel diameter (4.5 +/- 1.21, 2.65 +/- 0.58, and 0.81 +/- 0.14 nmol. mg(-1). h(-1) in the arcuate, interlobar, and segmental arteries, respectively). 20-HETE synthesis in the renal artery and the abdominal aorta was undetectable. The observed decreased immunoreactivity of NADPH-cytochrome P-450 (c) oxidoreductase with increased arterial diameter provided a possible explanation for the decreased capacity to generate 20-HETE in the large arteries. The increase in CYP4A isoform expression and 20-HETE synthesis with decreasing diameter along the preglomerular arteries and the potent biological activity of 20-HETE underscore the significance of 20-HETE as a modulator of renal hemodynamics." @default.
• W2327870009 created "2016-06-24" @default.
• W2327870009 creator A5041210629 @default.
• W2327870009 creator A5079107540 @default.
• W2327870009 creator A5085804210 @default.
• W2327870009 date "2002-07-01" @default.
• W2327870009 modified "2023-09-25" @default.
• W2327870009 title "Cytochrome<i>P</i>-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries" @default.
• W2327870009 cites W1499429603 @default.
• W2327870009 cites W184377109 @default.
• W2327870009 cites W1965198903 @default.
• W2327870009 cites W2013731273 @default.
• W2327870009 cites W2029733973 @default.
• W2327870009 cites W2031785180 @default.
• W2327870009 cites W2039852315 @default.
• W2327870009 cites W2042664484 @default.
• W2327870009 cites W2050079216 @default.
• W2327870009 cites W2050771112 @default.
• W2327870009 cites W2051648801 @default.
• W2327870009 cites W2053837499 @default.
• W2327870009 cites W2056814656 @default.
• W2327870009 cites W2065492522 @default.
• W2327870009 cites W2076161945 @default.
• W2327870009 cites W2084234371 @default.
• W2327870009 cites W2098809127 @default.
• W2327870009 cites W2108321491 @default.
• W2327870009 cites W2145558701 @default.
• W2327870009 cites W2155193020 @default.
• W2327870009 cites W2170106712 @default.
• W2327870009 cites W2184590027 @default.
• W2327870009 cites W2187459774 @default.
• W2327870009 cites W2218071932 @default.
• W2327870009 cites W2237332437 @default.
• W2327870009 cites W2245308845 @default.
• W2327870009 cites W2271187091 @default.
• W2327870009 cites W2399020375 @default.
• W2327870009 cites W2416613441 @default.
• W2327870009 cites W298015312 @default.
• W2327870009 doi "https://doi.org/10.1152/ajprenal.00265.2001" @default.
• W2327870009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12060587" @default.
• W2327870009 hasPublicationYear "2002" @default.
• W2327870009 type Work @default.
• W2327870009 sameAs 2327870009 @default.
• W2327870009 citedByCount "50" @default.
• W2327870009 countsByYear W23278700092012 @default.
• W2327870009 countsByYear W23278700092013 @default.
• W2327870009 countsByYear W23278700092014 @default.
• W2327870009 countsByYear W23278700092015 @default.
• W2327870009 countsByYear W23278700092016 @default.
• W2327870009 countsByYear W23278700092017 @default.
• W2327870009 countsByYear W23278700092018 @default.
• W2327870009 countsByYear W23278700092019 @default.
• W2327870009 countsByYear W23278700092022 @default.
• W2327870009 crossrefType "journal-article" @default.
• W2327870009 hasAuthorship W2327870009A5041210629 @default.
• W2327870009 hasAuthorship W2327870009A5079107540 @default.
• W2327870009 hasAuthorship W2327870009A5085804210 @default.
• W2327870009 hasConcept C104317684 @default.
• W2327870009 hasConcept C126322002 @default.
• W2327870009 hasConcept C134018914 @default.
• W2327870009 hasConcept C181199279 @default.
• W2327870009 hasConcept C185592680 @default.
• W2327870009 hasConcept C2776415932 @default.
• W2327870009 hasConcept C2776634560 @default.
• W2327870009 hasConcept C2778078955 @default.
• W2327870009 hasConcept C2779630222 @default.
• W2327870009 hasConcept C2779980429 @default.
• W2327870009 hasConcept C2780091579 @default.
• W2327870009 hasConcept C2780520971 @default.
• W2327870009 hasConcept C2780768313 @default.
• W2327870009 hasConcept C526171541 @default.
• W2327870009 hasConcept C53345823 @default.
• W2327870009 hasConcept C55493867 @default.
• W2327870009 hasConcept C62231903 @default.
• W2327870009 hasConcept C71924100 @default.
• W2327870009 hasConcept C86803240 @default.
• W2327870009 hasConceptScore W2327870009C104317684 @default.
• W2327870009 hasConceptScore W2327870009C126322002 @default.
• W2327870009 hasConceptScore W2327870009C134018914 @default.
• W2327870009 hasConceptScore W2327870009C181199279 @default.
• W2327870009 hasConceptScore W2327870009C185592680 @default.
• W2327870009 hasConceptScore W2327870009C2776415932 @default.
• W2327870009 hasConceptScore W2327870009C2776634560 @default.
• W2327870009 hasConceptScore W2327870009C2778078955 @default.
• W2327870009 hasConceptScore W2327870009C2779630222 @default.
• W2327870009 hasConceptScore W2327870009C2779980429 @default.
• W2327870009 hasConceptScore W2327870009C2780091579 @default.
• W2327870009 hasConceptScore W2327870009C2780520971 @default.
• W2327870009 hasConceptScore W2327870009C2780768313 @default.
• W2327870009 hasConceptScore W2327870009C526171541 @default.
• W2327870009 hasConceptScore W2327870009C53345823 @default.
• W2327870009 hasConceptScore W2327870009C55493867 @default.
• W2327870009 hasConceptScore W2327870009C62231903 @default.
• W2327870009 hasConceptScore W2327870009C71924100 @default.
• W2327870009 hasConceptScore W2327870009C86803240 @default.
• W2327870009 hasIssue "1" @default.
• W2327870009 hasLocation W23278700091 @default.
• W2327870009 hasLocation W23278700092 @default.

• next