FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327882177> ?p ?o ?g. }

• W2327882177 endingPage "B86" @default.
• W2327882177 startingPage "B86" @default.
• W2327882177 abstract "Background: While elevated circulating estrogens are consistently associated with increased postmenopausal breast cancer risk, less is known regarding the role of estrogen metabolism in breast carcinogenesis. Estrogen metabolism occurs via hydroxylation at the C-2,-4, or -16 positions, resulting in metabolites with potentially different genotoxic and mitogenic effects. To date, only two prior studies have examined comprehensive estrogen metabolism profiles in relation to postmenopausal breast cancer risk. Methods: We conducted a case-cohort study within B∼FIT (n=15,595), the Breast and Bone Follow-up to the Fracture Intervention Trial, to evaluate 15 pre-diagnostic serum estrogens and estrogen metabolites in relation to postmenopausal breast cancer risk. Participants included 387 breast cancer cases diagnosed during the 10-year follow-up and a subcohort of 492 women randomly selected from the cohort within 10-year age and geographical strata. At the screening visit (1992-1993), female volunteers ages 55-80 completed a baseline questionnaire and provided a blood sample. For cases, the average (SD) time between blood draw and diagnosis was 6 years (3.0). Serum concentrations of estrogens and estrogen metabolites were measured by liquid chromatography-tandem mass spectrometry. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard regression with robust variance adjustment. Exposures were categorized in quintiles (Q) based on the subcohort distribution; multivariable models were adjusted for study design variables (age, geographical site, and trial participation status). Known breast cancer risk factors were not included in the final models as additional adjustment did not alter the results. Estrogens were analyzed individually, as metabolic pathways (C-2, -4, or -16), and as ratios relative to the parent estrogens (estradiol and estrone). Results: Elevated circulating estradiol was significantly associated with increased breast cancer risk (HR Q5vsQ1 =1.70; 95% CI: 1.08-2.69), although no dose-response was observed (p-trend=0.12). No significant associations were observed in the analysis of individual metabolites or the 2- and 4-hydroxylation pathways. However, women in the highest quintile of the 16-hydroxylation pathway were significantly more likely to develop breast cancer as compared to those in the lowest (HR Q5vsQ1 =1.59; 95% CI: 1.02-2.48; p-trend=0.09). When analyzing each hydroxylation pathway relative to the parent estrogens, the ratio of the 2-hydroxylation pathway (HR Q5vsQ1 =0.76; 95% CI: 0.50-1.17; p-trend=0.06), 4-hydroxylation pathway (HR Q5vsQ1 =0.69; 95% CI: 0.45-1.06; p-trend=0.03) and 16-hydroxylation pathway (HR Q5vsQ1 =0.72; 95% CI: 0.47-1.10; P-trend=0.29) to parent estrogens was suggestive of inverse associations. Additionally, a higher ratio of the 2- to 16-hydroxylation pathways was significantly associated with reduced risk (HR Q5vsQ1 =0.66; 95% CI: 0.43-0.99; p-trend=0.009). Conclusions: Our results suggest that women with increased 2- or 4-hydroxylation, relative to their circulating parent estrogens, may be at lower risk of postmenopausal breast cancer. Analyses of metabolic pathways, in addition to individual metabolites, may help elucidate the role of estrogen metabolism in breast carcinogenesis. Citation Format: Cher M. Dallal, Jeffrey A. Tice, Diana S.M. Buist, Douglas C. Bauer, James V. Lacey, Jane A. Cauley, Trisha F. Hue, Andrea LaCroix, Roni Falk, Ruth Pfeiffer, Barbara J. Fuhrman, Timothy D. Veenstra, Xia Xu, Louise A. Brinton. Estrogen metabolism and postmenopausal breast cancer risk in the B∼FIT cohort. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr B86." @default.
• W2327882177 created "2016-06-24" @default.
• W2327882177 creator A5018381415 @default.
• W2327882177 creator A5019010663 @default.
• W2327882177 creator A5021940540 @default.
• W2327882177 creator A5037297600 @default.
• W2327882177 creator A5039850031 @default.
• W2327882177 creator A5046879037 @default.
• W2327882177 creator A5054118824 @default.
• W2327882177 creator A5054575797 @default.
• W2327882177 creator A5056962949 @default.
• W2327882177 creator A5067291454 @default.
• W2327882177 creator A5068791999 @default.
• W2327882177 creator A5069551165 @default.
• W2327882177 creator A5076423165 @default.
• W2327882177 creator A5077710776 @default.
• W2327882177 date "2012-11-01" @default.
• W2327882177 modified "2023-09-23" @default.
• W2327882177 title "Abstract B86: Estrogen metabolism and postmenopausal breast cancer risk in the B∼FIT cohort" @default.
• W2327882177 doi "https://doi.org/10.1158/1940-6207.prev-12-b86" @default.
• W2327882177 hasPublicationYear "2012" @default.
• W2327882177 type Work @default.
• W2327882177 sameAs 2327882177 @default.
• W2327882177 citedByCount "0" @default.
• W2327882177 crossrefType "journal-article" @default.
• W2327882177 hasAuthorship W2327882177A5018381415 @default.
• W2327882177 hasAuthorship W2327882177A5019010663 @default.
• W2327882177 hasAuthorship W2327882177A5021940540 @default.
• W2327882177 hasAuthorship W2327882177A5037297600 @default.
• W2327882177 hasAuthorship W2327882177A5039850031 @default.
• W2327882177 hasAuthorship W2327882177A5046879037 @default.
• W2327882177 hasAuthorship W2327882177A5054118824 @default.
• W2327882177 hasAuthorship W2327882177A5054575797 @default.
• W2327882177 hasAuthorship W2327882177A5056962949 @default.
• W2327882177 hasAuthorship W2327882177A5067291454 @default.
• W2327882177 hasAuthorship W2327882177A5068791999 @default.
• W2327882177 hasAuthorship W2327882177A5069551165 @default.
• W2327882177 hasAuthorship W2327882177A5076423165 @default.
• W2327882177 hasAuthorship W2327882177A5077710776 @default.
• W2327882177 hasConcept C121608353 @default.
• W2327882177 hasConcept C126322002 @default.
• W2327882177 hasConcept C143998085 @default.
• W2327882177 hasConcept C201903717 @default.
• W2327882177 hasConcept C2777164284 @default.
• W2327882177 hasConcept C29456083 @default.
• W2327882177 hasConcept C3018603563 @default.
• W2327882177 hasConcept C42407357 @default.
• W2327882177 hasConcept C530470458 @default.
• W2327882177 hasConcept C71924100 @default.
• W2327882177 hasConcept C72563966 @default.
• W2327882177 hasConceptScore W2327882177C121608353 @default.
• W2327882177 hasConceptScore W2327882177C126322002 @default.
• W2327882177 hasConceptScore W2327882177C143998085 @default.
• W2327882177 hasConceptScore W2327882177C201903717 @default.
• W2327882177 hasConceptScore W2327882177C2777164284 @default.
• W2327882177 hasConceptScore W2327882177C29456083 @default.
• W2327882177 hasConceptScore W2327882177C3018603563 @default.
• W2327882177 hasConceptScore W2327882177C42407357 @default.
• W2327882177 hasConceptScore W2327882177C530470458 @default.
• W2327882177 hasConceptScore W2327882177C71924100 @default.
• W2327882177 hasConceptScore W2327882177C72563966 @default.
• W2327882177 hasIssue "11 Supplement" @default.
• W2327882177 hasLocation W23278821771 @default.
• W2327882177 hasOpenAccess W2327882177 @default.
• W2327882177 hasPrimaryLocation W23278821771 @default.
• W2327882177 hasRelatedWork W2031086945 @default.
• W2327882177 hasRelatedWork W2044789494 @default.
• W2327882177 hasRelatedWork W2054357403 @default.
• W2327882177 hasRelatedWork W2071974478 @default.
• W2327882177 hasRelatedWork W2073099101 @default.
• W2327882177 hasRelatedWork W2430969052 @default.
• W2327882177 hasRelatedWork W2897797914 @default.
• W2327882177 hasRelatedWork W3015125064 @default.
• W2327882177 hasRelatedWork W3112166790 @default.
• W2327882177 hasRelatedWork W377899687 @default.
• W2327882177 hasVolume "5" @default.
• W2327882177 isParatext "false" @default.
• W2327882177 isRetracted "false" @default.
• W2327882177 magId "2327882177" @default.
• W2327882177 workType "article" @default.