FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327886701> ?p ?o ?g. }

• W2327886701 abstract "The immune system is one of the most complex signal processing machineries in biology. The adaptive immune system, consisting of B and T lymphocytes, is activated in response to a large spectrum of pathogen antigens. B cells recognize and bind the antigen through B-cell receptors (BCRs) and this is fundamental for B-cell activation. However, the system response is dependent on BCR-antigen affinity values that span several orders of magnitude. Moreover, the ability of the BCR to discriminate between affinities at the high end (e.g., ${10}^{9}{M}^{ensuremath{-}1}$--${10}^{10}{M}^{ensuremath{-}1}$) challenges the formulation of a mathematical model able to robustly separate these affinity-dependent responses. Queuing theory enables the analysis of many related processes, such as those resulting from the stochasticity of protein binding and unbinding events. Here we define a network of queues, consisting of BCR early signaling states and transition rates related to the propensity of molecular aggregates to form or disassemble. By considering the family of marginal distributions of BCRs in a given signaling state, we report a significant separation (measured as Jensen-Shannon divergence) that arises from a broad spectrum of antigen affinities." @default.
• W2327886701 created "2016-06-24" @default.
• W2327886701 creator A5021888589 @default.
• W2327886701 creator A5036529265 @default.
• W2327886701 date "2012-06-28" @default.
• W2327886701 modified "2023-10-16" @default.
• W2327886701 title "Network-of-queues approach to B-cell-receptor affinity discrimination" @default.
• W2327886701 cites W1589053023 @default.
• W2327886701 cites W1769080122 @default.
• W2327886701 cites W1965555277 @default.
• W2327886701 cites W1967139887 @default.
• W2327886701 cites W1977395168 @default.
• W2327886701 cites W1982022868 @default.
• W2327886701 cites W1991779626 @default.
• W2327886701 cites W1993717675 @default.
• W2327886701 cites W2006950109 @default.
• W2327886701 cites W2009375488 @default.
• W2327886701 cites W2010226849 @default.
• W2327886701 cites W2024184910 @default.
• W2327886701 cites W2039073711 @default.
• W2327886701 cites W2045073072 @default.
• W2327886701 cites W2049027605 @default.
• W2327886701 cites W2049886753 @default.
• W2327886701 cites W2066342287 @default.
• W2327886701 cites W2070505228 @default.
• W2327886701 cites W2070785786 @default.
• W2327886701 cites W2071423255 @default.
• W2327886701 cites W2103020160 @default.
• W2327886701 cites W2111402149 @default.
• W2327886701 cites W2139941949 @default.
• W2327886701 cites W2143764675 @default.
• W2327886701 cites W2149999958 @default.
• W2327886701 cites W2167935917 @default.
• W2327886701 cites W4239403073 @default.
• W2327886701 doi "https://doi.org/10.1103/physreve.85.061926" @default.
• W2327886701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23005146" @default.
• W2327886701 hasPublicationYear "2012" @default.
• W2327886701 type Work @default.
• W2327886701 sameAs 2327886701 @default.
• W2327886701 citedByCount "3" @default.
• W2327886701 countsByYear W23278867012013 @default.
• W2327886701 countsByYear W23278867012014 @default.
• W2327886701 countsByYear W23278867012016 @default.
• W2327886701 crossrefType "journal-article" @default.
• W2327886701 hasAuthorship W2327886701A5021888589 @default.
• W2327886701 hasAuthorship W2327886701A5036529265 @default.
• W2327886701 hasConcept C121332964 @default.
• W2327886701 hasConcept C147483822 @default.
• W2327886701 hasConcept C157695867 @default.
• W2327886701 hasConcept C159654299 @default.
• W2327886701 hasConcept C160403385 @default.
• W2327886701 hasConcept C170493617 @default.
• W2327886701 hasConcept C193419808 @default.
• W2327886701 hasConcept C22684755 @default.
• W2327886701 hasConcept C2778453870 @default.
• W2327886701 hasConcept C2780283098 @default.
• W2327886701 hasConcept C31258907 @default.
• W2327886701 hasConcept C41008148 @default.
• W2327886701 hasConcept C43907098 @default.
• W2327886701 hasConcept C54355233 @default.
• W2327886701 hasConcept C55493867 @default.
• W2327886701 hasConcept C86803240 @default.
• W2327886701 hasConcept C8891405 @default.
• W2327886701 hasConcept C95444343 @default.
• W2327886701 hasConceptScore W2327886701C121332964 @default.
• W2327886701 hasConceptScore W2327886701C147483822 @default.
• W2327886701 hasConceptScore W2327886701C157695867 @default.
• W2327886701 hasConceptScore W2327886701C159654299 @default.
• W2327886701 hasConceptScore W2327886701C160403385 @default.
• W2327886701 hasConceptScore W2327886701C170493617 @default.
• W2327886701 hasConceptScore W2327886701C193419808 @default.
• W2327886701 hasConceptScore W2327886701C22684755 @default.
• W2327886701 hasConceptScore W2327886701C2778453870 @default.
• W2327886701 hasConceptScore W2327886701C2780283098 @default.
• W2327886701 hasConceptScore W2327886701C31258907 @default.
• W2327886701 hasConceptScore W2327886701C41008148 @default.
• W2327886701 hasConceptScore W2327886701C43907098 @default.
• W2327886701 hasConceptScore W2327886701C54355233 @default.
• W2327886701 hasConceptScore W2327886701C55493867 @default.
• W2327886701 hasConceptScore W2327886701C86803240 @default.
• W2327886701 hasConceptScore W2327886701C8891405 @default.
• W2327886701 hasConceptScore W2327886701C95444343 @default.
• W2327886701 hasIssue "6" @default.
• W2327886701 hasLocation W23278867011 @default.
• W2327886701 hasLocation W23278867012 @default.
• W2327886701 hasOpenAccess W2327886701 @default.
• W2327886701 hasPrimaryLocation W23278867011 @default.
• W2327886701 hasRelatedWork W1656467347 @default.
• W2327886701 hasRelatedWork W2023282567 @default.
• W2327886701 hasRelatedWork W2058536807 @default.
• W2327886701 hasRelatedWork W2091838767 @default.
• W2327886701 hasRelatedWork W2126995540 @default.
• W2327886701 hasRelatedWork W2151539969 @default.
• W2327886701 hasRelatedWork W2327886701 @default.
• W2327886701 hasRelatedWork W4210280487 @default.
• W2327886701 hasRelatedWork W4321487662 @default.
• W2327886701 hasRelatedWork W1967124540 @default.
• W2327886701 hasVolume "85" @default.
• W2327886701 isParatext "false" @default.
• W2327886701 isRetracted "false" @default.

• next