Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327888945> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2327888945 endingPage "392" @default.
- W2327888945 startingPage "387" @default.
- W2327888945 abstract "Two regimens of 5FU and folinic acid in the treatment of metastatic colorectal cancer were retrospectively analyzed. 33 patients received the high dose (HD) schedule (5FU 370 mg/m2 and Folinic Acid 200 mg/m2 IV on D1-5, every 4 weeks), 61 patients received the low dose (LD) schedule (5FU 400 mg/m2 and Folinic Acid 20 mg/m2 IV on D1-5, every 4 weeks). One patient in each group achieved a complete response, the overall response rate was 28% and 11% for the HD and LD groups, respectively. The median response duration was 183 days for the HD and 112 days for the LD group. The median survival duration was 387 days for the HD and 405 days for the LD group. The response rate and duration of response were higher in the HD group though this did not reach statistical significance. There was no difference in overall survival between the two patient groups. Neutropenia and gastro-intestinal symptoms were the most common toxicities, they were equal in both groups. One patient (3%) in the HD and 5 patients (9%) in LD group discontinued treatment due to toxicity. There were no treatment related deaths. It is concluded that low dose folinic acid in combination with 5FU is effective and produces similar toxicities as high dose folinic acid. It is concluded that low dose folinic acid in combination with 5FU is an effective alternative to high dose regimen in the palliative management of patients with metastatic colorectal cancer. However though it did not reach statistical significance the high dose regimen was associated with a higher response rate. This could have a significant effect when the combination is used in the adjuvant treatment of high risk patients." @default.
- W2327888945 created "2016-06-24" @default.
- W2327888945 creator A5011001480 @default.
- W2327888945 creator A5012785119 @default.
- W2327888945 creator A5032344802 @default.
- W2327888945 creator A5034663584 @default.
- W2327888945 creator A5075197701 @default.
- W2327888945 date "1997-08-01" @default.
- W2327888945 modified "2023-09-25" @default.
- W2327888945 title "Retrospective Comparative Analysis of 5FU + Low-Dose Folinic Acid vs. 5FU + High-Dose Folinic Acid in the Treatment of Metastatic Colorectal Cancer" @default.
- W2327888945 cites W1844072307 @default.
- W2327888945 cites W1847455118 @default.
- W2327888945 cites W2253033732 @default.
- W2327888945 cites W2274948752 @default.
- W2327888945 cites W2330563871 @default.
- W2327888945 cites W2410215996 @default.
- W2327888945 cites W2586419939 @default.
- W2327888945 cites W2602544133 @default.
- W2327888945 cites W4293241248 @default.
- W2327888945 doi "https://doi.org/10.1097/00000421-199708000-00014" @default.
- W2327888945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9256896" @default.
- W2327888945 hasPublicationYear "1997" @default.
- W2327888945 type Work @default.
- W2327888945 sameAs 2327888945 @default.
- W2327888945 citedByCount "3" @default.
- W2327888945 crossrefType "journal-article" @default.
- W2327888945 hasAuthorship W2327888945A5011001480 @default.
- W2327888945 hasAuthorship W2327888945A5012785119 @default.
- W2327888945 hasAuthorship W2327888945A5032344802 @default.
- W2327888945 hasAuthorship W2327888945A5034663584 @default.
- W2327888945 hasAuthorship W2327888945A5075197701 @default.
- W2327888945 hasConcept C121608353 @default.
- W2327888945 hasConcept C126322002 @default.
- W2327888945 hasConcept C141071460 @default.
- W2327888945 hasConcept C2776694085 @default.
- W2327888945 hasConcept C2777063308 @default.
- W2327888945 hasConcept C2779804826 @default.
- W2327888945 hasConcept C2780456651 @default.
- W2327888945 hasConcept C2781413609 @default.
- W2327888945 hasConcept C29730261 @default.
- W2327888945 hasConcept C526805850 @default.
- W2327888945 hasConcept C71924100 @default.
- W2327888945 hasConcept C90924648 @default.
- W2327888945 hasConceptScore W2327888945C121608353 @default.
- W2327888945 hasConceptScore W2327888945C126322002 @default.
- W2327888945 hasConceptScore W2327888945C141071460 @default.
- W2327888945 hasConceptScore W2327888945C2776694085 @default.
- W2327888945 hasConceptScore W2327888945C2777063308 @default.
- W2327888945 hasConceptScore W2327888945C2779804826 @default.
- W2327888945 hasConceptScore W2327888945C2780456651 @default.
- W2327888945 hasConceptScore W2327888945C2781413609 @default.
- W2327888945 hasConceptScore W2327888945C29730261 @default.
- W2327888945 hasConceptScore W2327888945C526805850 @default.
- W2327888945 hasConceptScore W2327888945C71924100 @default.
- W2327888945 hasConceptScore W2327888945C90924648 @default.
- W2327888945 hasIssue "4" @default.
- W2327888945 hasLocation W23278889451 @default.
- W2327888945 hasLocation W23278889452 @default.
- W2327888945 hasOpenAccess W2327888945 @default.
- W2327888945 hasPrimaryLocation W23278889451 @default.
- W2327888945 hasRelatedWork W2012864969 @default.
- W2327888945 hasRelatedWork W2026758790 @default.
- W2327888945 hasRelatedWork W2092470860 @default.
- W2327888945 hasRelatedWork W2101429368 @default.
- W2327888945 hasRelatedWork W2127026223 @default.
- W2327888945 hasRelatedWork W2364607478 @default.
- W2327888945 hasRelatedWork W2383619798 @default.
- W2327888945 hasRelatedWork W2410470690 @default.
- W2327888945 hasRelatedWork W2417931553 @default.
- W2327888945 hasRelatedWork W2509837252 @default.
- W2327888945 hasVolume "20" @default.
- W2327888945 isParatext "false" @default.
- W2327888945 isRetracted "false" @default.
- W2327888945 magId "2327888945" @default.
- W2327888945 workType "article" @default.